Principles of Developmental Genetics

Principles of Developmental Genetics

1st Edition - July 19, 2007

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  • Editor: Sally Moody
  • eBook ISBN: 9780080550718

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Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.

Key Features

• Includes new research not previously published in any other book on the molecular genetic
processes that regulates development
• Chapters present a broad understanding on the application of animal model systems, allowing
researchers to better treat clinical disorders and comprehend human development
• Relates the application of new technologies to the manipulation of stem cells, causes of
human birth defects, and several human disease conditions
• Each chapter includes a bulleted summary highlighting clinical aspects of animal models


Clinical researchers and graduate students in genetics, developmental biology, cell and molecular biology, stem cell research, and evolutionary biology

Table of Contents

  • I. The Impact of Genetic and Genomic Tools on Developmental Biology

    1. Untangling the Gordian knot: Cell Signaling Events that Instruct Development
    Philippe Soriano and Renée V. Hoch

    2. Finding Gene Expression Changes using Microarray Technology
    Tadayoshi Hayata and Ken W.Y. Cho

    3. Chemical and Functional Genomic Approaches to Study Stem Cell Biology and Regeneration
    Wen Xiong and Sheng Ding

    4. Assessing Neural Stem Cell Properties using Large Scale Genomic Analysis
    Soojung Shin, Jonathan D. Chesnut and Mahendra S. Rao

    5. Epigenetic Influences on Gene Expression Pathways
    Sundeep Kalantry and Terry Magnuson

    6. New Insights into Vertebrate Origins
    Billie J. Swalla

    7. Understanding Human Birth Defects Through Model Organism Studies
    Feyza Engin and Brendan Lee

    II. Early Embryology, Fate Determination and Patterning

    8. Germ Line Determinants and Oogenesis
    Kelly M Haston and Renee A Reijo Pera

    9. Patterning the Anterior-Posterior Axis during Drosophila Embryogenesis
    Kristy L. Kenyon

    10. Anterior-Posterior Patterning in Mammals
    Sigolène M. Meilhac

    11. Signaling Cascades, Gradients, and Gene Networks in Dorsal/Ventral Patterning
    Girish S. Ratnaparkhi and Albert J. Courey

    12. Early Development of Epidermis and Neural Tissue
    Keiji Itoh and Sergei Y. Sokol

    13. Formation of the Embryonic Mesoderm
    Lisa L. Chang and Daniel S. Kessler

    14. Endoderm
    Debora Sinner, James M Wells and Aaron M. Zorn

    15. Notch Signaling – A Versatile Tool for the Fine Patterning of Cell Fate in Development
    Ajay B. Chitnis

    16. Multiple roles of T-box genes
    L. A. Naiche and Virginia E. Papaioannou

    III. Morphogenetic and Cell Movements

    17. Gastrulation in Vertebrates
    Lilianna Solnica-Krezel and Diane S. Sepich

    18. Regulation of tissue separation in the amphibian embryo
    Herbert Steinbeisser

    19. Role of the Basement Membrane in Cell Migration
    Kiyoji Nishiwaki, Kiyoji Nishiwaki and Yukihiko Kubota

    20. Epithelial Morphogenesis
    Ronit Wilk and Howard D. Lipshitz

    21. Branching Morphogenesis of Mammalian epithelia
    Jamie Davies

    22. The Roles of Ephrin-Eph in Morphogenesis
    Ira O. Daar

    IV. Ectodermal Organs

    23. Neural Cell Fate Determination
    Stephen N. Sansom and Frederick J. Livesey

    24. Pathfinding and Patterning of Axonal Connections
    S.A Linn, S.R. Kadison and C.E. Krull

    25 Retinal Development
    Kathryn B. Moore and Monica L. Vetter

    26. Neural Crest Determination
    Roberto Mayor

    27. Determination of Pre-Placodal Ectoderm and Sensory Placodes
    Sally A. Moody

    28. Molecular Genetics of Tooth Development
    Irma Thesleff

    29. The Inner Ear
    Donna F. Fekete and Ulrike J. Sienknecht

    30. Craniofacial Formation and Congenital Defects
    S.A. Brugmann and J.A. Helms

    V. Mesodermal Organs

    31. Induction of the Cardiac Lineage
    Andrew S. Warkman and Paul A. Krieg

    32. Heart Patterning and Congenital Defects
    John Belmont

    33. Blood Vessel Formation
    Karina Yaniv and Brant M. Weinstein

    34. Blood Induction and Embryonic Formation
    Xiaoying Bai and Leonard I. Zon

    35. Topics in Vertebrate Kidney Formation: A Comparative Perspective
    Thomas M. Schultheiss

    36. Development of The Genital System
    Hongling Du hugh S Taylor

    37. Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects
    Kate G. Ackerman and David R. Beier

    38. Formation of Vertebrate Limbs
    Yingzi Yang

    39. Skeletal Development
    Peter G. Alexander, Amanda T. Boyce, and Rocky S. Tuan

    VI. Endodermal Organs

    40. Patterning the Embryonic Endoderm into Presumptive Organ Domains
    Billie A. Moore-Scott and James M. Wells

    41. Developmental Genetics of the Pulmonary System
    Thomas J. Mariani

    42. Pancreas Development and Stem Cells
    Maureen Gannon

    43. Early Liver Development and Hepatic Progenitor Cells
    Jay D. Kormish and Kenneth S. Zaret

    44. Intestinal Stem Cells in Physiologic Regeneration and Disease
    David H. Scoville, Xi C. He, Goo Lee, Toshiro Sato, Terrence A. Barrett, and Linheng Li

Product details

  • No. of pages: 912
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: July 19, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080550718

About the Editor

Sally Moody

Sally Moody
Sally A. Moody is Professor of Anatomy and Cell Biology at the George Washington University Medical Center, and a member of both the Neuroscience and Genetics programs. Prior to this appointment she was on the faculty of the Anatomy and Cell Biology Department, the Department of Neuroscience, and the Developmental Biology program at the University of Virginia. She trained in developmental neurobiology at the University of Florida’s Department of Neuroscience and the University of Utah’s Department of Neurobiology and Anatomy. Dr. Moody’s current research focuses on the cascade of interactions that instruct lineages to give rise to the frog nervous system. She has taught developmental neurobiology in the MBL "Neurobiology" course and was co-director of the "Early Development of Xenopus Laevis" course at the Cold Spring Harbor Laboratory. She has also served on many National Institute of Health advisory committees dealing with issues in developmental biology and developmental neurobiology, and served on the Board of Trustees of the Society for Developmental Biology.

Affiliations and Expertise

George Washington University, Washington, DC, USA

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