Principles of Developmental Genetics - 1st Edition - ISBN: 9780123695482, 9780080550718

Principles of Developmental Genetics

1st Edition

Editors: Sally Moody
eBook ISBN: 9780080550718
Imprint: Academic Press
Published Date: 19th July 2007
Page Count: 1080
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Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.

Key Features

• Includes new research not previously published in any other book on the molecular genetic processes that regulates development • Chapters present a broad understanding on the application of animal model systems, allowing researchers to better treat clinical disorders and comprehend human development • Relates the application of new technologies to the manipulation of stem cells, causes of human birth defects, and several human disease conditions • Each chapter includes a bulleted summary highlighting clinical aspects of animal models


Clinical researchers and graduate students in genetics, developmental biology, cell and molecular biology, stem cell research, and evolutionary biology

Table of Contents

I. The Impact of Genetic and Genomic Tools on Developmental Biology

1. Untangling the Gordian knot: Cell Signaling Events that Instruct Development
Philippe Soriano and Renée V. Hoch

2. Finding Gene Expression Changes using Microarray Technology
Tadayoshi Hayata and Ken W.Y. Cho

3. Chemical and Functional Genomic Approaches to Study Stem Cell Biology and Regeneration
Wen Xiong and Sheng Ding

4. Assessing Neural Stem Cell Properties using Large Scale Genomic Analysis
Soojung Shin, Jonathan D. Chesnut and Mahendra S. Rao

5. Epigenetic Influences on Gene Expression Pathways
Sundeep Kalantry and Terry Magnuson

6. New Insights into Vertebrate Origins
Billie J. Swalla

7. Understanding Human Birth Defects Through Model Organism Studies
Feyza Engin and Brendan Lee

II. Early Embryology, Fate Determination and Patterning

8. Germ Line Determinants and Oogenesis
Kelly M Haston and Renee A Reijo Pera

9. Patterning the Anterior-Posterior Axis during Drosophila Embryogenesis
Kristy L. Kenyon

10. Anterior-Posterior Patterning in Mammals
Sigolène M. Meilhac

11. Signaling Cascades, Gradients, and Gene Networks in Dorsal/Ventral Patterning
Girish S. Ratnaparkhi and Albert J. Courey

12. Early Development of Epidermis and Neural Tissue
Keiji Itoh and Sergei Y. Sokol

13. Formation of the Embryonic Mesoderm
Lisa L. Chang and Daniel S. Kessler

14. Endoderm
Debora Sinner, James M Wells and Aaron M. Zorn

15. Notch Signaling – A Versatile Tool for the Fine Patterning of Cell Fate in Development
Ajay B. Chitnis

16. Multiple roles of T-box genes
L. A. Naiche and Virginia E. Papaioannou

III. Morphogenetic and Cell Movements

17. Gastrulation in Vertebrates
Lilianna Solnica-Krezel and Diane S. Sepich

18. Regulation of tissue separation in the amphibian embryo
Herbert Steinbeisser

19. Role of the Basement Membrane in Cell Migration
Kiyoji Nishiwaki, Kiyoji Nishiwaki and Yukihiko Kubota

20. Epithelial Morphogenesis
Ronit Wilk and Howard D. Lipshitz

21. Branching Morphogenesis of Mammalian epithelia
Jamie Davies

22. The Roles of Ephrin-Eph in Morphogenesis
Ira O. Daar

IV. Ectodermal Organs

23. Neural Cell Fate Determination
Stephen N. Sansom and Frederick J. Livesey

24. Pathfinding and Patterning of Axonal Connections
S.A Linn, S.R. Kadison and C.E. Krull

25 Retinal Development
Kathryn B. Moore and Monica L. Vetter

26. Neural Crest Determination
Roberto Mayor

27. Determination of Pre-Placodal Ectoderm and Sensory Placodes
Sally A. Moody

28. Molecular Genetics of Tooth Development
Irma Thesleff

29. The Inner Ear
Donna F. Fekete and Ulrike J. Sienknecht

30. Craniofacial Formation and Congenital Defects
S.A. Brugmann and J.A. Helms

V. Mesodermal Organs

31. Induction of the Cardiac Lineage
Andrew S. Warkman and Paul A. Krieg

32. Heart Patterning and Congenital Defects
John Belmont

33. Blood Vessel Formation
Karina Yaniv and Brant M. Weinstein

34. Blood Induction and Embryonic Formation
Xiaoying Bai and Leonard I. Zon

35. Topics in Vertebrate Kidney Formation: A Comparative Perspective
Thomas M. Schultheiss

36. Development of The Genital System
Hongling Du hugh S Taylor

37. Diaphragmatic Embryogenesis and Human Congenital Diaphragmatic Defects
Kate G. Ackerman and David R. Beier

38. Formation of Vertebrate Limbs
Yingzi Yang

39. Skeletal Development
Peter G. Alexander, Amanda T. Boyce, and Rocky S. Tuan

VI. Endodermal Organs

40. Patterning the Embryonic Endoderm into Presumptive Organ Domains
Billie A. Moore-Scott and James M. Wells

41. Developmental Genetics of the Pulmonary System
Thomas J. Mariani

42. Pancreas Development and Stem Cells
Maureen Gannon

43. Early Liver Development and Hepatic Progenitor Cells
Jay D. Kormish and Kenneth S. Zaret

44. Intestinal Stem Cells in Physiologic Regeneration and Disease
David H. Scoville, Xi C. He, Goo Lee, Toshiro Sato, Terrence A. Barrett, and Linheng Li


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© Academic Press 2007
Academic Press
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About the Editor

Sally Moody

Sally Moody

Sally A. Moody is Professor of Anatomy and Cell Biology at the George Washington University Medical Center, and a member of both the Neuroscience and Genetics programs. Prior to this appointment she was on the faculty of the Anatomy and Cell Biology Department, the Department of Neuroscience, and the Developmental Biology program at the University of Virginia. She trained in developmental neurobiology at the University of Florida’s Department of Neuroscience and the University of Utah’s Department of Neurobiology and Anatomy. Dr. Moody’s current research focuses on the cascade of interactions that instruct lineages to give rise to the frog nervous system. She has taught developmental neurobiology in the MBL "Neurobiology" course and was co-director of the "Early Development of Xenopus Laevis" course at the Cold Spring Harbor Laboratory. She has also served on many National Institute of Health advisory committees dealing with issues in developmental biology and developmental neurobiology, and served on the Board of Trustees of the Society for Developmental Biology.

Affiliations and Expertise

George Washington University, Washington, DC, USA

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