Phytoconstituents and Antifungals
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Phytoconstituents and Antifungals covers a wide range of specific information on various phytoconstituents, their antifungal mode and the diagnosis and management of fungal infections. The book offers encouragement and empowers readers to re-embrace their knowledge of phytoconstituents and their various antifungal activities against most opportunistic pathogenic fungi as fungal diseases cause an estimated 1.5+ million deaths annually and over one billion people suffer from severe fungal disease. In this complex scenario, it is now clear that global warming and accompanying climate changes have resulted in increased incidence of many fungal infections. On the basis of all these factors, concerns on the occurrence of a pandemic fungal origin in the near future have been raised. In this context, to stop forgetting and underestimating fungal diseases is mandatory.
Key Features
- Provides readers with up-to-date information on different phytoconstituents over fungal strain
- Collectively addresses important and updated material on fungal diseases
- Conveys the knowledge needed to understand and improve success in managing and combating fungal diseases worldwide
Readership
Researchers and investigators working in the area of pathogenic human fungal infections. Researchers in applied microbiology, molecular biology, mycology, biotechnology, biochemistry, Pharmaceutical industry, Medicinal Chemistry, Drug Discovery etc; Basic and applied scientists of different disciplines (microbiologist, molecular biologists, medicinal chemists, mycologist) specialists in different sub-disciplines of phytomedicines, and students in postgraduate and PhD programs
Table of Contents
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Acknowledgment
- 1. Major diseases caused by fungal infections
- Introduction
- 2. Antifungal discovery from plant sources
- Introduction
- Plant selection for the discovery of antifungal
- Importance of medicinal plants
- Extraction and characterization of plant extract
- Plant materials
- Solvent selection
- Techniques of extraction
- Methods of antifungal susceptibility testing
- Screening of antifungals through bioautographic techniques
- 3. Phytoconstituents as antifungals
- Searching for phytochemicals from medicinal plants
- Phytochemicals for antimicrobial activity
- Action of phytoconstituents over microorganisms
- Phytoconstituents classification
- Types of terpenes
- Biosynthesis of phytoconstituents
- 4. Plant alkaloids
- Introduction
- Biology and bioactivity of alkaloids
- Elicitor signal transduction for plant alkaloids biosynthesis
- Extraction and evaluation of plant alkaloids
- Antifungal activities of alkaloids from natural sources
- 5. Plant phenolics
- Introduction
- 6. Plant terpenes
- Introduction
- Chemical structure
- Classification of terpenes
- Terpenes as an antifungal agent
- General properties of terpenoids
- Terpenes as agents of biotransformation
- Terpene's chemistry and biosynthesis
- Regulation of plant terpenoid biosynthesis
- Transgenic plants and future research
- Conclusion
- 7. Glycosides and polysaccharides
- Introduction
- Two important plant glycosides that behave as antifungals
- Therapeutic properties of glycones (polysaccharides) and glycosides against pathogens
- Mechanism of antifungal sensitivity of glycosides
- 8. Peptides and polypeptides
- Introduction
- Molecular structure composition of peptide molecules
- Therapeutic role of bioactive AMPs on pathogenic fungus
- Natural AFPs
- Synthetic AFPs
- Antifungal peptides with synergistic effects
- Delivery of therapeutic peptides and polypeptides
- 9. Oils and resins
- Introduction
- Natural architecture of plant oils
- Biosynthesis of major components of essential oil
- Action mechanism of essential oils over fungal cells
- Antifungal action against opportunistic mycoses
- 10. Conclusions
- Summary
- References
- Index
Product details
- No. of pages: 166
- Language: English
- Copyright: © Academic Press 2022
- Published: August 20, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323917926
- eBook ISBN: 9780323986175
About the Editor
Awanish Kumar
Dr. Awanish Kumar is currently an Associate Professor in the Department of Biotechnology at the National Institute of Technology, Raipur (CG), India. He is working in the area of infection biology, drug targeting, and drug discovery. He has more than 13 years of research experience. He received his PhD in molecular parasitology from the CSIR-Central Drug Research Institute-Lucknow, India and Jawaharlal Nehru University-Delhi, India. He did his post-doctoral study at McGill University, Montreal, Canada. Dr. Kumar has served various national and international organizations in different academic and research capacities. He has authored several monographs, books, and book chapters. He has served on many national committees, scientific society and advisory panels, is a member of many international professional research societies and as a reviewer and editorial board member of reputed and refereed journals.
Affiliations and Expertise
Associate Professor, Department of Biotechnology, National Institute of Technology Raipur, India
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