Perinatal Stem Cells - 1st Edition - ISBN: 9780128120156

Perinatal Stem Cells

1st Edition

Editors: Anthony Atala Kyle Cetrulo Rouzbeh Taghizadeh Curtis Cetrulo Sean Murphy
Hardcover ISBN: 9780128120156
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 600
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Perinatal Stem Cells: Research and Therapy provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources such as amniotic fluid, placenta and placental membranes, umbilical cord and Wharton’s jelly. The volume is compiled by leading experts in the field and offers the reader a detailed insight into sources of perinatal stem cells, and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. The rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on ‘Clinical and Industry Perspectives’ which provides insight into the new opportunities and challenges involved in this novel and exciting industry.

Key Features

  • Explores current clinical and pre-clinical application of stem cells derived from perinatal sources
  • Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment
  • Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells
  • Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells


Advanced students and researchers in stem cell biology, regenerative medicine and tissue engineering, and developmental biology

Table of Contents

Section I. Amniotic Fluid-Derived Stem Cells
1. In utero therapy for congenital disorders using amniotic fluid stem cells
2. The Amniotic Fluid Stem Cell Secretome: at the Heart of Regeneration
3. Transplantation of Amniotic Fluid-Derived Neural Stem Cells
4. Stroke therapy: the potential of amniotic fluid-derived stem cells
5. Vascular formation by human perinatal stem cells
6. Amniotic Fluid Stem Cells for Kidney Regeneration

Section II. Placental and Placental Membrane-Derived Stem Cells
7. Placental mesenchymal stem cells for cellular cardiomyoplasty
8. Heterogeneous functions of perinatal mesenchymal stromal cells require a preselection before their banking for clinical use
9. Defining the fetal stem cell niche in the human placenta
10. Banking placental tissue hematopoietic stem cells and mesenchymal stem cells for clinical use
11. Immuno-modulatory mechanisms of placental stem cells
12. Amnion Membrane Allograft for Regenerative Medicine
13. Placental Stem Cells
14. Therapeutic Effect of Extracellular Vesicles Derived from Adult/Perinatal Human Mesenchymal Stem Cells

Section III. Umbilical Cord-Derived Cells
15. Ex-vivo Expansion of Cord Blood Stem Cells
16. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells
17. Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children
18. Phenotypic and Functional Characterization Perinatal Stem Cells Isolated from Umbilical Cord Tissue
19. Mesenchymal stromal cells from Wharton’s jelly (WJ-MSCs): coupling their hidden differentiative program with their frank immunomodulatory phenotype
20. Regeneration of ischemic cardiovascular damage using Jelly Wharton as an unlimited source of therapeutic stem cells
21. Phenotype with Focused Paracrine Fractions: Effecting Future Phenotype with Focused Paracrine Fractions

Section IV. Clinical and Industry Perspective
22. Clinical Translation of Perinatal Stem Cell Therapy
23. Current Clinical Trials utilizing Perinatal Stem Cells – A Review
24. Review Of Processing Technology and Techniques for Perinatal Stem Cells Banking And Clinical Applications
25. Clinical Development And Commercialization Of Placenta-Derived Cell Therapy
26. How the patent landscape has changed
27. The Need for Better Assays to Predict the Effectiveness of Tissue Stem Cell Treatments


No. of pages:
© Academic Press 2018
Academic Press
Hardcover ISBN:

About the Editor

Anthony Atala

The Wake Forest Institute for Regenerative Medicine was the first in the world to engineer and successfully implant an engineered organ in the lab -- bladders. As Director of the Institute, Dr. Atala oversees scientists working on therapies for more than 30 areas of the body, from heart valves and muscle tissue to livers and kidneys. Atala has received the Christopher Columbus Foundation Award, given to a living American who is currently working on a discovery that will significantly affect society. He is listed in Best Doctors in America.

Affiliations and Expertise

Department of Urology, Wake Forest University, Winston-Salem, NC, USA

Kyle Cetrulo

Affiliations and Expertise

Chief Executive Officer, AuxoCell Laboratories, Inc., Cambridge, MA, USA

Rouzbeh Taghizadeh

Affiliations and Expertise

Co-Founder, Chief Scientific Officer, AuxoCell Laboratories, Inc., Cambridge, MA, USA

Curtis Cetrulo

Affiliations and Expertise

Assistant Professor, Surgery, Harvard Medical School, Plastic and Reconstructive Surgery, Surgery, Massachusetts General Hospital, USA

Sean Murphy

Affiliations and Expertise

Assistant Professor, Wake Forest Institute for Regenerative Medicine, USA