Description

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.

Key Features

  • Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research
  • Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information
  • Includes four color images throughout

Readership

Researchers working with nonhuman primates and those dealing with laboratory animal husbandry; Veterinarians in private practice who work with nonhuman primates; Biologists and zoologists who wish to expand their knowledge of nonhuman primates.

Table of Contents

American College of Laboratory Animal Medicine Series

Preface

Acknowledgments

Reviewers

Contributors

Chapter 1. Viral Diseases of Nonhuman Primates

Introduction

Enveloped DNA Viruses

Nonenveloped DNA-Containing Viruses

Enveloped RNA-Containing Viruses

Nonenveloped RNA-Containing Viruses

Chapter 2. Bacterial and Mycotic Diseases of Nonhuman Primates

Introduction

Bacterial Diseases

Mycotic Diseases

Chapter 3. Tuberculosis Research using Nonhuman Primates

Introduction

Human Tuberculosis

Pathobiology of Human Disease: Natural History of Tuberculosis

Primate Models of Tuberculosis

Pathological Features of Model

Statistical Considerations

Occupational Health and Safety Considerations: Biosafety Level 3 Pathogen

Specific Areas of Research that Benefit from the Nonhuman Primate Model of Tuberculosis

Alternative Animal Models, In Silico Models, and In Vitro Systems

Summary

Acknowledgments

Chapter 4. Parasitic Diseases of Nonhuman Primates

Introduction

Protozoan Parasites

Metazoan Parasites

Acknowledgments

Chapter 5. Nonhuman Primate Models for Human Malaria Research

Introduction

Human Malaria

Life Cycle of Primate Malaria Parasites

Clinical Malaria and Pathology

Nonhuman Primate Models of Human Malaria (Biology, Disease Pathogenesis, Immunity, and Testing of Vaccines or Drugs)

Some Methods and Considerations for Investigations of Malaria Biology and Vaccines

Chapter 6. Neoplasia and Proliferative Disorders of Nonhuman Primates

Introduction

Characterization of Neoplasia

Mechanisms of Cancer Development

System Specific Neoplasia

Treatment and Prognosis

Chapter 7. Hematopoietic, Cardiovascular, Lymphoid and Mononuclear Phagocyte Systems of Nonhuman Primates

I

Details

No. of pages:
868
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
eBook ISBN:
9780123978387
Print ISBN:
9780123813664
Print ISBN:
9780128102862

About the editors

Christian Abee

Affiliations and Expertise

University of Texas, MD Anderson Cancer Center, Michale E. Keeling Center for Comparative, Medicine and Research, Bastrop, Texas, U.S.A.

Keith Mansfield

Keith Mansfield is Associate Director for Resource and Collaborative Affairs and Chair, Division of Primate Resources, New England National Primate Research Center, Harvard Medical School, Harvard University, Southborough, US. His research focuses on primarily on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis.

Affiliations and Expertise

Novartis Institutes for Biomedical Research,Cambridge, MA, U.S.A.

Suzette Tardif

Suzette D. Tardif, Ph.D., is the Associate Director of Research at the Southwest National Primate Research Center. She is an adjunct faculty of The Barshop Institute. The Tardif laboratory's activities center on the development of the marmoset monkey as a disease model. Dr. Tardiff is a past-President of the American Society of Primatologists.

Affiliations and Expertise

Ph.D., Barshop Institute for Longevity & Aging Studies, San Antonio, TX

Timothy Morris

Affiliations and Expertise

The School of Veterinary Medicine and Science, The University of Nottingham, Leicestershire, UK

Reviews

"This two-volume set builds on the
earlier volumes, updates and expands the material to include a more
international perspective on regulatory oversight, important model systems, and research areas where non-human primates play a pivotal role. High-resolution color images support the text. The first volume contains 19 contributions, beginning with a history and including discussion of laws and regulations and of non-human primate taxonomy, social behavior, reproduction and breeding, and housing, as well as clinical and surgical techniques, anesthesia, and safety. The second volume, on diseases, contains 18 contributions on the specifics of research pertaining to tuberculosis, parasitic diseases, malaria, atherosclerosis, diabetes and obesity, nervous system disorders, and drug and alcohol addiction, among other topics."--Reference and Research Book News, August 2012, page 211