Neural Mechanisms of Addiction

Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field.

Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.

• Transcends multiple neural, neurochemical and behavioral domains
• Summarizes advances in the field of addiction research since the advent of optogenetics
• Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms

Advanced students and researchers in behavioral neuroscience, cognitive neuroscience, neurobiology, psychology, addiction science, and related fields

1. Introduction
2. Neural Plasticity in Addiction
3. Neural Circuit Alterations in Addiction
4. Mechanisms Regulating Compulsive Drug Seeking
5. Glutamatergic Neuroplasticity Underlying Drug Reinstatement
6. Negative Reinforcement Mechanisms in Addiction
7. Role of Stress-Associated Signaling in Addiction
8. Circadian Regulation in Addiction
9. Sleep Mechanisms Regulating Addiction
10. Neural Ensemble Encoding of Addictive Behavior
11. Glial Dysregulation in Addiction
12. Role of the Extracellular Matrix in Addiction
13. Neural Morphology and Addiction
14. Interactions between Natural Rewards and Addiction
15. Cognitive Dysfunction in Addiction
16. Instrumental Learning Mechanisms in Addiction
17. Pavlovian Learning Mechanisms in Addiction
18. Molecular Mechanisms of Addiction: Current Theories
19. Emerging Neural Circuits Regulating Addiction
20. Dopamine Mechanisms in Addiction: Current Theories
21. Cell Type Specific Plasticity in Addiction
22. Neuropeptide Mechanisms in Addiction
23. Epigenetics and Addiction
24. Mechanisms for Harnessing Circuits for Treatment of Addictive Disorders
25. Conclusions and Future Directions