Neural Mechanisms of Addiction

Neural Mechanisms of Addiction

1st Edition - August 24, 2018

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  • Editor: Mary Torregrossa
  • Paperback ISBN: 9780128122020
  • eBook ISBN: 9780128123317

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Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.

Key Features

  • Transcends multiple neural, neurochemical and behavioral domains
  • Summarizes advances in the field of addiction research since the advent of optogenetics
  • Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms


Advanced students and researchers in behavioral neuroscience, cognitive neuroscience, neurobiology, psychology, addiction science, and related fields

Table of Contents

  • 1. Introduction
    Mary M. Torregrossa
    2. Animal Models of Addiction
    Rita A. Fuchs
    3. Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug Addiction
    A.J. Robison
    4. Neural Circuit Alterations in Addiction
    Matt Hearing and Eden Marie Anderson
    5. Glutamatergic Neuroplasticity in Addiction
    L. A. Knackstedt and Allison Bechard
    6. Neural Ensemble Encoding of Addictive Behavior
    Bruce Hope
    7. Interoceptive Stimulus Effects of Drugs of Abuse
    Jennifer Murray
    8. Maladaptive Memory Mechanisms in Addiction and Relapse
    Mary M. Torregrossa
    9. Neural Morphology and Addiction
    Patrick Mulholland
    10. Mechanisms regulating compulsive drug behaviors
    David M. Dietz
    11. Role of Stress-Associated Signaling in Addiction
    John Mantsch and Elizabeth M. Doncheck
    12. Negative Reinforcement Mechanisms in Addiction
    Olivier George
    13. Circadian Rhythms and Addiction
    Ryan Logan
    14. Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by Stress
    Jacqueline McGinty
    15. The Role of Norepinephrine in Addiction: Past, Present, and Future
    David Weinshenker
    16. Glial Dysregulation in Addiction
    David Baker
    17. Role of the Extracellular Matrix in Addiction
    Peter W. Kalivas and Lauren Beloate
    18. Striatal cell-type specific plasticity in addiction
    Mary Kay Lobo
    19. Harnessing Circuits for the Treatment of Addictive Disorders
    Christelle Baunez
    20. Conclusions and Future Directions
    Mary M. Torregrossa

Product details

  • No. of pages: 306
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: August 24, 2018
  • Imprint: Academic Press
  • Paperback ISBN: 9780128122020
  • eBook ISBN: 9780128123317

About the Editor

Mary Torregrossa

Mary Torregrossa has conducted research in the neuroscience of addiction field for 16 years, including studying opiates, psychostimulants, alcohol, and cannabinoids in addition to investigating the neural mechanisms underlying addiction and potential treatments using a variety of techniques, including behavioral analyses, pharmacology, microdialysis, biochemistry, molecular biology, and proteomics. Dr. Torregrossa began her career by earning her Ph.D. at the University of Michigan in the laboratory of Dr. James Woods, one of the “founding fathers” of behavioral pharmacological studies of addictive disorders using animal models, and, as a postdoctoral fellow, trained with two other leaders in the addiction field, Dr. Peter Kalivas and Dr. Jane Taylor. Dr. Torregrossa is now an independent investigator in the Department of Psychiatry at the University of Pittsburgh, funded by the National Institute on Drug Abuse. She is the author of nearly 30 peer-reviewed articles in the field, as well as numerous reviews and book chapters.

Affiliations and Expertise

Assistant Professor, Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA

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