Neural Mechanisms of Addiction

Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field.

Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.

• Transcends multiple neural, neurochemical and behavioral domains
• Summarizes advances in the field of addiction research since the advent of optogenetics
• Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms

Advanced students and researchers in behavioral neuroscience, cognitive neuroscience, neurobiology, psychology, addiction science, and related fields

1. Introduction
   Mary M. Torregrossa
   2. Animal Models of Addiction
   Rita A. Fuchs
   3. Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug Addiction
   A.J. Robison
   4. Neural Circuit Alterations in Addiction
   Matt Hearing and Eden Marie Anderson
   5. Glutamatergic Neuroplasticity in Addiction
   L. A. Knackstedt and Allison Bechard
   6. Neural Ensemble Encoding of Addictive Behavior
   Bruce Hope
   7. Interoceptive Stimulus Effects of Drugs of Abuse
   Jennifer Murray
   8. Maladaptive Memory Mechanisms in Addiction and Relapse
   Mary M. Torregrossa
   9. Neural Morphology and Addiction
   Patrick Mulholland
   10. Mechanisms regulating compulsive drug behaviors
   David M. Dietz
   11. Role of Stress-Associated Signaling in Addiction
   John Mantsch and Elizabeth M. Doncheck
   12. Negative Reinforcement Mechanisms in Addiction
   Olivier George
   13. Circadian Rhythms and Addiction
   Ryan Logan
   14. Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by Stress
   Jacqueline McGinty
   15. The Role of Norepinephrine in Addiction: Past, Present, and Future
   David Weinshenker
   16. Glial Dysregulation in Addiction
   David Baker
   17. Role of the Extracellular Matrix in Addiction
   Peter W. Kalivas and Lauren Beloate
   18. Striatal cell-type specific plasticity in addiction
   Mary Kay Lobo
   19. Harnessing Circuits for the Treatment of Addictive Disorders
   Christelle Baunez
   20. Conclusions and Future Directions
   Mary M. Torregrossa