Multiscale Modeling of Developmental Systems - 1st Edition - ISBN: 9780123742537, 9780080556536

Multiscale Modeling of Developmental Systems, Volume 81

1st Edition

Serial Volume Editors: Santiago Schnell Philip Maini Stuart A. Newman Timothy Newman
Serial Editors: Gerald Schatten
eBook ISBN: 9780080556536
Hardcover ISBN: 9780123742537
Imprint: Academic Press
Published Date: 18th December 2007
Page Count: 604
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Table of Contents

Chapter 1 Introduction Philip K. Maini, Stuart A. Newman, Timothy J. Newman and Santiago Schnell

Chapter 2 Models of biological pattern formation: from elementary steps to the organization of embryonic axes Hans Meinhardt

Chapter 3 Robustness of embryonic spatial patterning in Drosophila melanogaster David Umulis, Michael B. O’Connor and Hans G. Othmer

Chapter 4 Integrating morphogenesis with underlying mechanics and cell biology. Lance A. Davidson

Chapter 5 The mechanisms underlying primitive streak formation in the chick embryo Manli Chuai, Cornelis J Weijer

Chapter 6 Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formation T. J. Newman

Chapter 7 Mathematical models for somite formation Ruth E. Baker, Santiago Schnell and Philip K. Maini

Chapter 8 Coordinated Action of N-CAM, N-cadherin, EphA4 and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick James A. Glazier, Ying Zhang, Maciej Swat, Benjamin Zaitlen, Santiago Schnell

Chapter 9 Branched organs: Mechanics of morphogenesis by multiple mechanisms Sharon R Lubkin

Chapter 10 Multicellular sprouting during vasculogenesis Andras Czirok, Evan A. Zamir, Andras Szabo and Charles D. Little

Chapter 11 Modelling lung branching morphogenesis Takashi Miura

Chapter 12 Multiscale Models for Vertebrate Limb Development Stuart A. Newman, Scott Christley, Tilmann Glimm, H.G.E. Hentschel, Bogdan Kazmierczak, Yong-Tao Zhang, Jianfeng Zhu and Mark Alber

Chapter 13 Tooth morphogenesis in vivo, in vitro and in silico Isaac Salazar-Ciudad

Chapter 14 Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation Michael Meyer-Hermann

Chapter 15 Cellular automata as microscopic models of cell migration in heterogeneous environments H. Hatzikirou and A. Deutsch

Chapter 16 Multiscale modeling of biological pattern formation Ramon Grima

Chapter 17 Relating Biophysical Properties Across Scales Elijah Flenner, Francoise Marga, Adrian Neagu, Ioan Kosztin, Gabor Forgacs

Chapter 18 Complex Multicellular Systems and Immune Competition: New Paradigms Looking for a Mathematical Theory N. Bellomo, G. Forni


Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation. This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds.

Key Features

  • Articles written by leading exponents in the field
  • Provides techniques to address multiscale modeling
  • Coverage includes a wide spectrum of modeling approaches
  • Includes descriptions of the most recent advances in the field


Graduate students and scientists in developmental biology, mathematical sciences, biomathematics, and general life sciences.


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© Academic Press 2008
Academic Press
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Ratings and Reviews

About the Serial Volume Editors

Santiago Schnell Serial Volume Editor

Philip Maini Serial Volume Editor

Stuart A. Newman Serial Volume Editor

Timothy Newman Serial Volume Editor

About the Serial Editors

Gerald Schatten Serial Editor

Affiliations and Expertise

University of Pittsburgh School of Medicine, PA, U.S.A.