Molecular Basis of Cardiovascular Disease

2nd Edition

A Companion to Braunwald's Heart Disease

Authors: Kenneth Chien
Print ISBN: 9780721694283
eBook ISBN: 9781437713459
Imprint: Saunders
Published Date: 19th March 2004
Page Count: 704


The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease · the molecular basis of ischemic disease, thrombosis and hypertension · genetic mapping approaches to inherited disorders · biologically targeted agents for hypertension and heart failure · and much more. Abundant figures and tables illustrate key concepts.

Key Features

  • Addresses most common cardiovascular problems from a molecular standpoint.
  • Explores developing treatments for cardiovascular problems based on genetics.
  • Provides references to Braunwald's Heart Disease, 6th Edition

Table of Contents

I. General Principles of Molecular Cardiology

Chapter 1: Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 2: Human Genome Project and Cardiovascular Disease Genes (CC Liew, Victor J. Dzau)
Chapter 3: Model Organisms for Cardiac Disease Gene Discovery (Calum A. Macrae, Mark C. Fishman)
Chapter 4: Generation and Cloning of Genetically Modified Animals (Leon J. DeWindt, Pieter A. Doevendans, Kenneth R. Chien)
Chapter 5: Mouse Models of Human Cardiovascular Disease (Geir Christensen, Ju Chen, John Ross, Jr., Kenneth Chien)
Chapter 6: Towards Stem Cell Therapy (Pieter A. Doevendans, Christine Mummery, Kenneth Chien)
Chapter 7: Cardiovascular Signaling Pathways (Susan F. Steinberg, Michael Karin, Joan Heller Brown)
Chapter 8: Genetic Approaches to Cardiovascular Disease (Carl J. Vaughan, Craig T. Basson)
Chapter 9: Gene Transfer Approaches for Cardiovascular Disease (Elizabeth Nabel)

II. Cardiac Development and Congenital Heart Disease

Chapter 10: Cardiac Development and Congenital Heart Disease (Deepak Srivastava, Eric N. Olson)
Chapter 11: Development of Pacemaking and Cardiac Conduction System Lineages (Robert G. Gourdie, Steven W. Kubalak, Terrence X. O’Brien, Kenneth R. Chien, Takashi Mikawa)
Chapter 12: Cardiac Laterality and Congenital Heart Disease (Pilar Ruiz-Lozano, Angel Raya, Kenneth R. Chien, Juan Carlos Izpisua-Belmonte)
Chapter 13: Pharyngeal Apparatus and Cardiac Neural Crest Defects (Antonio Baldini)
Chapter 14: Monogenic Causes of Congenital Heart Disease (Joachim P. Schmitt, Christine E. Seidman)

III. Cardiac Muscle Diseases

Chapter 15: Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (Masahiko Hoshijima, Susumu Minamisawa, Hideo Yasukawa, Kenneth R. Chien)
Chapter 16: Molecular Genetics of Inherited Cardiomyopathies (Christopher Semsa


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© Saunders 2004
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Hardcover ISBN:

About the Author

Kenneth Chien

Affiliations and Expertise

Director, Institute of MOlecular Medicine, UCSD; Professor, UCSD Department of Medicine and the Salk Institute (Adjunct), La Jolla, CA; American Heart Association Endowed Chair