Molecular Basis of Cardiovascular Disease - 2nd Edition - ISBN: 9780721694283, 9781437713459

Molecular Basis of Cardiovascular Disease

2nd Edition

A Companion to Braunwald's Heart Disease

Authors: Kenneth Chien
eBook ISBN: 9781437713459
Hardcover ISBN: 9780721694283
Imprint: Saunders
Published Date: 19th March 2004
Page Count: 704

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Table of Contents

I. General Principles of Molecular Cardiology

Chapter 1: Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 2: Human Genome Project and Cardiovascular Disease Genes (CC Liew, Victor J. Dzau)
Chapter 3: Model Organisms for Cardiac Disease Gene Discovery (Calum A. Macrae, Mark C. Fishman)
Chapter 4: Generation and Cloning of Genetically Modified Animals (Leon J. DeWindt, Pieter A. Doevendans, Kenneth R. Chien)
Chapter 5: Mouse Models of Human Cardiovascular Disease (Geir Christensen, Ju Chen, John Ross, Jr., Kenneth Chien)
Chapter 6: Towards Stem Cell Therapy (Pieter A. Doevendans, Christine Mummery, Kenneth Chien)
Chapter 7: Cardiovascular Signaling Pathways (Susan F. Steinberg, Michael Karin, Joan Heller Brown)
Chapter 8: Genetic Approaches to Cardiovascular Disease (Carl J. Vaughan, Craig T. Basson)
Chapter 9: Gene Transfer Approaches for Cardiovascular Disease (Elizabeth Nabel)

II. Cardiac Development and Congenital Heart Disease

Chapter 10: Cardiac Development and Congenital Heart Disease (Deepak Srivastava, Eric N. Olson)
Chapter 11: Development of Pacemaking and Cardiac Conduction System Lineages (Robert G. Gourdie, Steven W. Kubalak, Terrence X. O’Brien, Kenneth R. Chien, Takashi Mikawa)
Chapter 12: Cardiac Laterality and Congenital Heart Disease (Pilar Ruiz-Lozano, Angel Raya, Kenneth R. Chien, Juan Carlos Izpisua-Belmonte)
Chapter 13: Pharyngeal Apparatus and Cardiac Neural Crest Defects (Antonio Baldini)
Chapter 14: Monogenic Causes of Congenital Heart Disease (Joachim P. Schmitt, Christine E. Seidman)

III. Cardiac Muscle Diseases

Chapter 15: Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (Masahiko Hoshijima, Susumu Minamisawa, Hideo Yasukawa, Kenneth R. Chien)
Chapter 16: Molecular Genetics of Inherited Cardiomyopathies (Christopher Semsarian, J.F. Seidman, and Christine E. Seidman)
Chapter 17: Molecular Pathways for Dilated Cardiomyopathy (K. Campbell)Chapter
18: Excitability and Conduction (Michael J. Ackerman, David E. Clapham)
Chapter 19: Cardiac Arrhythmias: Inherited Molecular Mechanisms (Steve A. N. Goldstein, Mark T. Keating, Michael C. Sanguinetti)

IV. Atherogenesis

Chapter 20: Inflammation and Immunity in Atherogenesis (Peter Libby, Göran K. Hansson and Jordan S. Pober)
Chapter 21: Molecular Biology of Lipoproteins and Dyslipidemias (Sotirios Tsimikas, Vincent Mooser)
Chapter 22: Lipoprotein Oxidation, Macrophages, Immunity and Atherogenesis (Sotirios Tsimikas, Christopher K. Glass, Daniel Steinberg and Joseph L. Witztum)
Chapter 23: Cellular Cholesterol Metabolism in Health and Disease (Ira Tabas)

V. Ischemic Diseases and Angiogenesis

Chapter 24: Angiogenesis in Cardiovascular Disease (Karen S. Moulton, Judah Folkman)
Chapter 25: Coronary Restenosis (Hiroshi Ashikaga, Ori Ben-Yehuda, Kenneth R. Chien)
Chapter 26: Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults (Stuart A. Lipton, Stephen F. Heinemann)

VI. Thrombosis

Chapter 27: Platelets and Anti-Platelet Therapy in Cardiovascular Disease: Molecular Mechanisms (Ori Ben-Yehuda)
Chapter 28: Blood Coagulation and Atherothrombosis (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 29: Thrombosis and Thrombolytic Therapy (H.R. Lijnen, H. Pannekoek, J. Vermylen)

VII. Hypertension

Chapter 30: Molecular Targets of Antihypertensive Drug Therapy (Edwin W. Williems, Ahsan Husain, Robert M. Graham)
Chapter 31: Mechanisms and Molecular Pathways in Hypertension (Roger Brown, John Mullins, David J. Webb)

VIII. Environmental and Genetic Modifiers of Cardiovascular Disease

Chapter 32: Molecular Biology of Transplantation and Xenotransplantation
(Patrick Hildbrand, Daniel R. Salomon)
Chapter 33: Viral Infections of the Heart (Kirk U. Knowlton, Hervé Duplain)

IX. Glossary: Resources, Websites


The 2nd Edition of this heralded companion to Braunwald's Heart Disease explores the molecular mechanisms of cardiology and the scientific advances that are changing the practice of cardiology today. International experts discuss the role of genetics in cardiovascular disease · the molecular basis of ischemic disease, thrombosis and hypertension · genetic mapping approaches to inherited disorders · biologically targeted agents for hypertension and heart failure · and much more. Abundant figures and tables illustrate key concepts.

Key Features

  • Addresses most common cardiovascular problems from a molecular standpoint.
  • Explores developing treatments for cardiovascular problems based on genetics.
  • Provides references to Braunwald's Heart Disease, 6th Edition


No. of pages:
© Saunders 2004
eBook ISBN:
Hardcover ISBN:

About the Authors

Kenneth Chien Author

Affiliations and Expertise

Director, Institute of MOlecular Medicine, UCSD; Professor, UCSD Department of Medicine and the Salk Institute (Adjunct), La Jolla, CA; American Heart Association Endowed Chair