Molecular Basis of Cardiovascular Disease - 2nd Edition - ISBN: 9780721694283, 9781437713459

Molecular Basis of Cardiovascular Disease

2nd Edition

A Companion to Braunwald's Heart Disease

Authors: Kenneth Chien
Hardcover ISBN: 9780721694283
eBook ISBN: 9781437713459
Imprint: Saunders
Published Date: 19th March 2004
Page Count: 704
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Table of Contents

I. General Principles of Molecular Cardiology

Chapter 1: Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 2: Human Genome Project and Cardiovascular Disease Genes (CC Liew, Victor J. Dzau)
Chapter 3: Model Organisms for Cardiac Disease Gene Discovery (Calum A. Macrae, Mark C. Fishman)
Chapter 4: Generation and Cloning of Genetically Modified Animals (Leon J. DeWindt, Pieter A. Doevendans, Kenneth R. Chien)
Chapter 5: Mouse Models of Human Cardiovascular Disease (Geir Christensen, Ju Chen, John Ross, Jr., Kenneth Chien)
Chapter 6: Towards Stem Cell Therapy (Pieter A. Doevendans, Christine Mummery, Kenneth Chien)
Chapter 7: Cardiovascular Signaling Pathways (Susan F. Steinberg, Michael Karin, Joan Heller Brown)
Chapter 8: Genetic Approaches to Cardiovascular Disease (Carl J. Vaughan, Craig T. Basson)
Chapter 9: Gene Transfer Approaches for Cardiovascular Disease (Elizabeth Nabel)

II. Cardiac Development and Congenital Heart Disease

Chapter 10: Cardiac Development and Congenital Heart Disease (Deepak Srivastava, Eric N. Olson)
Chapter 11: Development of Pacemaking and Cardiac Conduction System Lineages (Robert G. Gourdie, Steven W. Kubalak, Terrence X. O’Brien, Kenneth R. Chien, Takashi Mikawa)
Chapter 12: Cardiac Laterality and Congenital Heart Disease (Pilar Ruiz-Lozano, Angel Raya, Kenneth R. Chien, Juan Carlos Izpisua-Belmonte)
Chapter 13: Pharyngeal Apparatus and Cardiac Neural Crest Defects (Antonio Baldini)
Chapter 14: Monogenic Causes of Congenital Heart Disease (Joachim P. Schmitt, Christine E. Seidman)

III. Cardiac Muscle Diseases

Chapter 15: Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (Masahiko Hoshijima, Susumu Minamisawa, Hideo Yasukawa, Kenneth R. Chien)
Chapter 16: Molecular Genetics of Inherited Cardiomyopathies (Christopher Semsarian, J.F. Seidman, and Christine E. Seidman)
Chapter 17: Molecular Pathways for Dilated Cardiomyopathy (K. Campbell)Chapter
18: Excitability and Conduction (Michael J. Ackerman, David E. Clapham)
Chapter 19: Cardiac Arrhythmias: Inherited Molecular Mechanisms (Steve A. N. Goldstein, Mark T. Keating, Michael C. Sanguinetti)

IV. Atherogenesis

Chapter 20: Inflammation and Immunity in Atherogenesis (Peter Libby, Göran K. Hansson and Jordan S. Pober)
Chapter 21: Molecular Biology of Lipoproteins and Dyslipidemias (Sotirios Tsimikas, Vincent Mooser)
Chapter 22: Lipoprotein Oxidation, Macrophages, Immunity and Atherogenesis (Sotirios Tsimikas, Christopher K. Glass, Daniel Steinberg and Joseph L. Witztum)
Chapter 23: Cellular Cholesterol Metabolism in Health and Disease (Ira Tabas)

V. Ischemic Diseases and Angiogenesis

Chapter 24: Angiogenesis in Cardiovascular Disease (Karen S. Moulton, Judah Folkman)
Chapter 25: Coronary Restenosis (Hiroshi Ashikaga, Ori Ben-Yehuda, Kenneth R. Chien)
Chapter 26: Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults (Stuart A. Lipton, Stephen F. Heinemann)

VI. Thrombosis

Chapter 27: Platelets and Anti-Platelet Therapy in Cardiovascular Disease: Molecular Mechanisms (Ori Ben-Yehuda)
Chapter 28: Blood Coagulation and Atherothrombosis (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 29: Thrombosis and Thrombolytic Therapy (H.R. Lijnen, H. Pannekoek, J. Vermylen)

VII. Hypertension

Chapter 30: Molecular Targets of Antihypertensive Drug Therapy (Edwin W. Williems, Ahsan Husain, Robert M. Graham)
Chapter 31: Mechanisms and Molecular Pathways in Hypertension (Roger Brown, John Mullins, David J. Webb)

VIII. Environmental and Genetic Modifiers of Cardiovascular Disease

Chapter 32: Molecular Biology of Transplantation and Xenotransplantation
(Patrick Hildbrand, Daniel R. Salomon)
Chapter 33: Viral Infections of the Heart (Kirk U. Knowlton, Hervé Duplain)

IX. Glossary: Resources, Websites

Description

I. General Principles of Molecular Cardiology

Chapter 1: Biotechnology and Cardiovascular Medicine: Recombinant Protein Therapy (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 2: Human Genome Project and Cardiovascular Disease Genes (CC Liew, Victor J. Dzau)
Chapter 3: Model Organisms for Cardiac Disease Gene Discovery (Calum A. Macrae, Mark C. Fishman)
Chapter 4: Generation and Cloning of Genetically Modified Animals (Leon J. DeWindt, Pieter A. Doevendans, Kenneth R. Chien)
Chapter 5: Mouse Models of Human Cardiovascular Disease (Geir Christensen, Ju Chen, John Ross, Jr., Kenneth Chien)
Chapter 6: Towards Stem Cell Therapy (Pieter A. Doevendans, Christine Mummery, Kenneth Chien)
Chapter 7: Cardiovascular Signaling Pathways (Susan F. Steinberg, Michael Karin, Joan Heller Brown)
Chapter 8: Genetic Approaches to Cardiovascular Disease (Carl J. Vaughan, Craig T. Basson)
Chapter 9: Gene Transfer Approaches for Cardiovascular Disease (Elizabeth Nabel)

II. Cardiac Development and Congenital Heart Disease

Chapter 10: Cardiac Development and Congenital Heart Disease (Deepak Srivastava, Eric N. Olson)
Chapter 11: Development of Pacemaking and Cardiac Conduction System Lineages (Robert G. Gourdie, Steven W. Kubalak, Terrence X. O’Brien, Kenneth R. Chien, Takashi Mikawa)
Chapter 12: Cardiac Laterality and Congenital Heart Disease (Pilar Ruiz-Lozano, Angel Raya, Kenneth R. Chien, Juan Carlos Izpisua-Belmonte)
Chapter 13: Pharyngeal Apparatus and Cardiac Neural Crest Defects (Antonio Baldini)
Chapter 14: Monogenic Causes of Congenital Heart Disease (Joachim P. Schmitt, Christine E. Seidman)

III. Cardiac Muscle Diseases

Chapter 15: Molecular Pathways for Cardiac Hypertrophy and Heart Failure Progression (Masahiko Hoshijima, Susumu Minamisawa, Hideo Yasukawa, Kenneth R. Chien)
Chapter 16: Molecular Genetics of Inherited Cardiomyopathies (Christopher Semsarian, J.F. Seidman, and Christine E. Seidman)
Chapter 17: Molecular Pathways for Dilated Cardiomyopathy (K. Campbell)Chapter
18: Excitability and Conduction (Michael J. Ackerman, David E. Clapham)
Chapter 19: Cardiac Arrhythmias: Inherited Molecular Mechanisms (Steve A. N. Goldstein, Mark T. Keating, Michael C. Sanguinetti)

IV. Atherogenesis

Chapter 20: Inflammation and Immunity in Atherogenesis (Peter Libby, Göran K. Hansson and Jordan S. Pober)
Chapter 21: Molecular Biology of Lipoproteins and Dyslipidemias (Sotirios Tsimikas, Vincent Mooser)
Chapter 22: Lipoprotein Oxidation, Macrophages, Immunity and Atherogenesis (Sotirios Tsimikas, Christopher K. Glass, Daniel Steinberg and Joseph L. Witztum)
Chapter 23: Cellular Cholesterol Metabolism in Health and Disease (Ira Tabas)

V. Ischemic Diseases and Angiogenesis

Chapter 24: Angiogenesis in Cardiovascular Disease (Karen S. Moulton, Judah Folkman)
Chapter 25: Coronary Restenosis (Hiroshi Ashikaga, Ori Ben-Yehuda, Kenneth R. Chien)
Chapter 26: Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults (Stuart A. Lipton, Stephen F. Heinemann)

VI. Thrombosis

Chapter 27: Platelets and Anti-Platelet Therapy in Cardiovascular Disease: Molecular Mechanisms (Ori Ben-Yehuda)
Chapter 28: Blood Coagulation and Atherothrombosis (Hiroshi Ashikaga, Kenneth R. Chien)
Chapter 29: Thrombosis and Thrombolytic Therapy (H.R. Lijnen, H. Pannekoek, J. Vermylen)

VII. Hypertension

Chapter 30: Molecular Targets of Antihypertensive Drug Therapy (Edwin W. Williems, Ahsan Husain, Robert M. Graham)
Chapter 31: Mechanisms and Molecular Pathways in Hypertension (Roger Brown, John Mullins, David J. Webb)

VIII. Environmental and Genetic Modifiers of Cardiovascular Disease

Chapter 32: Molecular Biology of Transplantation and Xenotransplantation
(Patrick Hildbrand, Daniel R. Salomon)
Chapter 33: Viral Infections of the Heart (Kirk U. Knowlton, Hervé Duplain)

IX. Glossary: Resources, Websites

Key Features

  • Addresses most common cardiovascular problems from a molecular standpoint.
  • Explores developing treatments for cardiovascular problems based on genetics.
  • Provides references to Braunwald's Heart Disease, 6th Edition

Details

No. of pages:
704
Language:
English
Copyright:
© Saunders 2004
Published:
Imprint:
Saunders
eBook ISBN:
9781437713459
Hardcover ISBN:
9780721694283

About the Authors

Kenneth Chien Author

Affiliations and Expertise

Director, Institute of MOlecular Medicine, UCSD; Professor, UCSD Department of Medicine and the Salk Institute (Adjunct), La Jolla, CA; American Heart Association Endowed Chair