Microfluidic Devices for Biomedical Applications - 1st Edition - ISBN: 9780857096975, 9780857097040

Microfluidic Devices for Biomedical Applications

1st Edition

Editors: Xiujun James Li Yu Zhou
eBook ISBN: 9780857097040
Hardcover ISBN: 9780857096975
Imprint: Woodhead Publishing
Published Date: 31st October 2013
Page Count: 676
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Table of Contents

Contributor contact details

Woodhead Publishing Series in Biomaterials

About the editors

Preface

Part I: Fundamentals of microfluidic technologies for biomedical applications

Chapter 1: Materials and methods for the microfabrication of microfluidic biomedical devices

Abstract:

1.1 Introduction

1.2 Microfabrication methods

1.3 Materials for biomedical devices

1.4 Polymers

1.5 Conclusion and future trends

1.7 Appendix: acronyms

Chapter 2: Surface coatings for microfluidic-based biomedical devices

Abstract:

2.1 Introduction

2.2 Covalent immobilization strategies: polymer devices

2.3 Covalent immobilization strategies: glass devices

2.4 Adsorption strategies

2.5 Other strategies utilizing surface treatments

2.6 Examples of applications

2.7 Conclusion and future trends

2.8 Sources of further information and advice

Chapter 3: Actuation mechanisms for microfluidic biomedical devices

Abstract:

3.1 Introduction

3.2 Electrokinetics

3.3 Acoustics

3.4 Limitations and future trends

Chapter 4: Digital microfluidics technologies for biomedical devices

Abstract:

4.1 Introduction

4.2 On-chip microdrop motion techniques

4.3 Sensing techniques

4.4 Future trends

4.5 Conclusion

Part II: Applications of microfluidic devices for drug delivery and discovery

Chapter 5: Controlled drug delivery using microfluidic devices

Abstract:

5.1 Introduction

5.2 Microreservoir-based drug delivery systems

5.3 Micro/nanofluidics-based drug delivery systems

5.4 Conclusion

5.5 Future trends

Chapter 6: Microneedles for drug delivery and monitoring

Abstract:

6.1 Introduction

6.2 Fabrication of microneedles (MNs)

6.3 MN design parameters and structure

6.4 Strategies for MN-based drug delivery

6.5 MN-mediated monitoring using skin interstitial fluid (ISF) and blood samples

6.6 Future trends

6.7 Conclusion

Chapter 7: Microfluidic devices for drug discovery and analysis

Abstract:

7.1 Introduction

7.2 Microfluidics for drug discovery

7.3 Microfluidics for drug analysis and diagnostic applications

7.4 Conclusion and future trends

7.5 Sources of further information and advice

Part III: Applications of microfluidic devices for cellular analysis and tissue engineering

Chapter 8: Microfluidic devices for cell manipulation

Abstract:

8.1 Introduction

8.2 Microenvironment on cell integrity

8.3 Microscale fluid dynamics

8.4 Manipulation technologies

8.5 Manipulation of cancer cells in microfluidic systems

8.6 Conclusion and future trends

8.7 Sources of further information and advice

Chapter 9: Microfluidic devices for single-cell trapping and automated micro-robotic injection

Abstract:

9.1 Introduction

9.2 Device design and microfabrication

9.3 Experimental results and discussion

9.4 Conclusion

9.5 Acknowledgements

Chapter 10: Microfluidic devices for developing tissue scaffolds

Abstract:

10.1 Introduction

10.2 Key issues and technical challenges for successful tissue engineering

10.3 Microfluidic device platforms

10.4 Conclusion and future trends

Chapter 11: Microfluidic devices for stem cell analysis

Abstract:

11.1 Introduction

11.2 Technologies used in stem cell analysis

11.3 Examples of microfluidic platform for stem cell analysis: stem cell culture platform – mimicking in vivo culture conditions in vitro

11.4 Examples of microfluidic platform for stem cell analysis: single stem cell analysis

11.5 Microdevices for label-free and non-invasive monitoring of stem cell differentiation

11.6 Microfluidics stem cell separation technology

11.7 Conclusion and future trends

Part IV: Applications of microfluidic devices in diagnostic sensing

Chapter 12: Development of immunoassays for protein analysis on nanobioarray chips

Abstract:

12.1 Introduction

12.2 Technologies

12.3 Immobilization chemistry

12.4 Detection methods

12.5 Applications

12.6 Conclusion and future trends

Chapter 13: Integrated microfluidic systems for genetic analysis

Abstract:

13.1 Introduction

13.2 Integrated microfluidic systems

13.3 Development of integrated microdevices

13.4 Applications of fully integrated systems in genetic analysis

13.5 Conclusion and future trends

Chapter 14: Low-cost assays in paper-based microfluidic biomedical devices

Abstract:

14.1 Introduction

14.2 Fabrication techniques for paper-based microfluidic devices

14.3 Detection and read-out technologies

14.4 Application of paper-based microfluidic devices

14.5 Conclusion and future trends

Chapter 15: Microfluidic devices for viral detection

Abstract:

15.1 Introduction

15.2 Microfluidic technologies used for viral detection

15.3 Examples of applications

15.4 Conclusion and future trends

15.5 Acknowledgements

Chapter 16: Microfluidics for monitoring and imaging pancreatic islet and β-cells for human transplant

Abstract:

16.1 Introduction

16.2 Insulin secretory pathway: how glucose sensing and metabolic coupling translates to insulin kinetics

16.3 Technologies: the emergence of microfluidics applied to islet and β-cell study

16.4 Design and fabrication of the University of Illinois at Chicago (UIC) microfluidic device

16.5 Protocol: materials

16.6 Protocol: procedures

16.7 Anticipated results

16.8 Acknowledgements

Chapter 17: Microfluidic devices for radio chemical synthesis

Abstract:

17.1 Introduction

17.2 Medical applications of microfluidic radiochemistry: positron emission tomography (PET) and single photon emission computed tomography (SPECT)

17.3 Advantages and disadvantages of microfluidic devices

17.4 Realization of promises: the superiority of microfluidic systems

17.5 Current problems for microfluidic technology

17.6 Recent developments with potential impact

17.7 Conclusion

Index


Description

Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.

The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.

Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

Key Features

  • Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications
  • Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies
  • Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

Readership

Medical device manufacturers, scientists, and researchers concerned with microfluidics in the field of drug delivery, cell manipulation, tissue engineering and diagnostics/sensing; Industrial and academic researchers and developers in the life sciences and engineering fields who aim to use microengineering technologies to develop advanced techniques and microdevices for advancements in healthcare and medical diagnostics


Details

No. of pages:
676
Language:
English
Copyright:
© Woodhead Publishing 2013
Published:
Imprint:
Woodhead Publishing
eBook ISBN:
9780857097040
Hardcover ISBN:
9780857096975

Reviews

"Mechanical and biomedical engineers, chemists, and other contributors briefly introduce the fundamentals of microfluidics, then survey current research into microfluidic devices or lab-on-chip platforms in biomedical applications. Among the topics are: surface coatings for microfluidic-based biomedical devices, actuation mechanisms,…"--ProtoView.com, March 2014


About the Editors

Xiujun James Li Editor

Assistant Professor, Department of Chemistry, University of Texas at El Paso and at the Harvard University and Wyss Institute.Professor Li is recently rewarded with the UT System STARS Award ($250,000). The STARS (Science and Technology Acquisition and Retention) program provides funding to help purchase state-of-the-art research equipment and make necessary laboratory renovations to encourage faculty members to perform their research.

Yu Zhou Editor

Yu Zhou, PhD, is a Research Scientist in the Department of Research and Development at ABS Global Inc., USA. Dr Zhou received his Ph.D. degree in mechanical engineering from University of Illinois at Chicago in 2010. After graduation, he joined ABS Global, the world-leading genetics provider company as a key researcher and has been working on the development of a high-throughput microfluidic cytometry for biological cell detection and manipulation. He obtained extensive experience in design and fabrication of silicon-based microsystems and disposal plastic microfluidic chips, precision fluid delivery, and microfluidics-based single cell separation and analysis. He is a member of ASME and serves on the advisory editorial board for several technical journals including Microsystem Technologies, and Journal of Mechanical Engineering Research (Canada) since 2011.

Affiliations and Expertise

Genus Plc, USA