Microfluidic Devices for Biomedical Applications
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Microfluidic Devices for Biomedical Applications

1st Edition - October 31, 2013

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  • Editors: Xiujun Li, Yu Zhou
  • eBook ISBN: 9780857097040
  • Hardcover ISBN: 9780857096975

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Description

Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.

Key Features

  • Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applications
  • Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies
  • Considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

Readership

Medical device manufacturers, scientists, and researchers concerned with microfluidics in the field of drug delivery, cell manipulation, tissue engineering and diagnostics/sensing; Industrial and academic researchers and developers in the life sciences and engineering fields who aim to use microengineering technologies to develop advanced techniques and microdevices for advancements in healthcare and medical diagnostics

Table of Contents

  • Contributor contact details

    Woodhead Publishing Series in Biomaterials

    About the editors

    Preface

    Part I: Fundamentals of microfluidic technologies for biomedical applications

    Chapter 1: Materials and methods for the microfabrication of microfluidic biomedical devices

    Abstract:

    1.1 Introduction

    1.2 Microfabrication methods

    1.3 Materials for biomedical devices

    1.4 Polymers

    1.5 Conclusion and future trends

    1.7 Appendix: acronyms

    Chapter 2: Surface coatings for microfluidic-based biomedical devices

    Abstract:

    2.1 Introduction

    2.2 Covalent immobilization strategies: polymer devices

    2.3 Covalent immobilization strategies: glass devices

    2.4 Adsorption strategies

    2.5 Other strategies utilizing surface treatments

    2.6 Examples of applications

    2.7 Conclusion and future trends

    2.8 Sources of further information and advice

    Chapter 3: Actuation mechanisms for microfluidic biomedical devices

    Abstract:

    3.1 Introduction

    3.2 Electrokinetics

    3.3 Acoustics

    3.4 Limitations and future trends

    Chapter 4: Digital microfluidics technologies for biomedical devices

    Abstract:

    4.1 Introduction

    4.2 On-chip microdrop motion techniques

    4.3 Sensing techniques

    4.4 Future trends

    4.5 Conclusion

    Part II: Applications of microfluidic devices for drug delivery and discovery

    Chapter 5: Controlled drug delivery using microfluidic devices

    Abstract:

    5.1 Introduction

    5.2 Microreservoir-based drug delivery systems

    5.3 Micro/nanofluidics-based drug delivery systems

    5.4 Conclusion

    5.5 Future trends

    Chapter 6: Microneedles for drug delivery and monitoring

    Abstract:

    6.1 Introduction

    6.2 Fabrication of microneedles (MNs)

    6.3 MN design parameters and structure

    6.4 Strategies for MN-based drug delivery

    6.5 MN-mediated monitoring using skin interstitial fluid (ISF) and blood samples

    6.6 Future trends

    6.7 Conclusion

    Chapter 7: Microfluidic devices for drug discovery and analysis

    Abstract:

    7.1 Introduction

    7.2 Microfluidics for drug discovery

    7.3 Microfluidics for drug analysis and diagnostic applications

    7.4 Conclusion and future trends

    7.5 Sources of further information and advice

    Part III: Applications of microfluidic devices for cellular analysis and tissue engineering

    Chapter 8: Microfluidic devices for cell manipulation

    Abstract:

    8.1 Introduction

    8.2 Microenvironment on cell integrity

    8.3 Microscale fluid dynamics

    8.4 Manipulation technologies

    8.5 Manipulation of cancer cells in microfluidic systems

    8.6 Conclusion and future trends

    8.7 Sources of further information and advice

    Chapter 9: Microfluidic devices for single-cell trapping and automated micro-robotic injection

    Abstract:

    9.1 Introduction

    9.2 Device design and microfabrication

    9.3 Experimental results and discussion

    9.4 Conclusion

    9.5 Acknowledgements

    Chapter 10: Microfluidic devices for developing tissue scaffolds

    Abstract:

    10.1 Introduction

    10.2 Key issues and technical challenges for successful tissue engineering

    10.3 Microfluidic device platforms

    10.4 Conclusion and future trends

    Chapter 11: Microfluidic devices for stem cell analysis

    Abstract:

    11.1 Introduction

    11.2 Technologies used in stem cell analysis

    11.3 Examples of microfluidic platform for stem cell analysis: stem cell culture platform – mimicking in vivo culture conditions in vitro

    11.4 Examples of microfluidic platform for stem cell analysis: single stem cell analysis

    11.5 Microdevices for label-free and non-invasive monitoring of stem cell differentiation

    11.6 Microfluidics stem cell separation technology

    11.7 Conclusion and future trends

    Part IV: Applications of microfluidic devices in diagnostic sensing

    Chapter 12: Development of immunoassays for protein analysis on nanobioarray chips

    Abstract:

    12.1 Introduction

    12.2 Technologies

    12.3 Immobilization chemistry

    12.4 Detection methods

    12.5 Applications

    12.6 Conclusion and future trends

    Chapter 13: Integrated microfluidic systems for genetic analysis

    Abstract:

    13.1 Introduction

    13.2 Integrated microfluidic systems

    13.3 Development of integrated microdevices

    13.4 Applications of fully integrated systems in genetic analysis

    13.5 Conclusion and future trends

    Chapter 14: Low-cost assays in paper-based microfluidic biomedical devices

    Abstract:

    14.1 Introduction

    14.2 Fabrication techniques for paper-based microfluidic devices

    14.3 Detection and read-out technologies

    14.4 Application of paper-based microfluidic devices

    14.5 Conclusion and future trends

    Chapter 15: Microfluidic devices for viral detection

    Abstract:

    15.1 Introduction

    15.2 Microfluidic technologies used for viral detection

    15.3 Examples of applications

    15.4 Conclusion and future trends

    15.5 Acknowledgements

    Chapter 16: Microfluidics for monitoring and imaging pancreatic islet and β-cells for human transplant

    Abstract:

    16.1 Introduction

    16.2 Insulin secretory pathway: how glucose sensing and metabolic coupling translates to insulin kinetics

    16.3 Technologies: the emergence of microfluidics applied to islet and β-cell study

    16.4 Design and fabrication of the University of Illinois at Chicago (UIC) microfluidic device

    16.5 Protocol: materials

    16.6 Protocol: procedures

    16.7 Anticipated results

    16.8 Acknowledgements

    Chapter 17: Microfluidic devices for radio chemical synthesis

    Abstract:

    17.1 Introduction

    17.2 Medical applications of microfluidic radiochemistry: positron emission tomography (PET) and single photon emission computed tomography (SPECT)

    17.3 Advantages and disadvantages of microfluidic devices

    17.4 Realization of promises: the superiority of microfluidic systems

    17.5 Current problems for microfluidic technology

    17.6 Recent developments with potential impact

    17.7 Conclusion

    Index

Product details

  • No. of pages: 676
  • Language: English
  • Copyright: © Woodhead Publishing 2013
  • Published: October 31, 2013
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780857097040
  • Hardcover ISBN: 9780857096975

About the Editors

Xiujun Li

XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at the University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University, while holding a Postdoctoral Fellowship from Natural Sciences and Engineering Research Council (NSERC) of Canada. He has gained extensive experience in bioanalysis using microfluidic systems, such as single-cell analysis, genetic analysis, low-cost diagnosis, pathogen detection, 3D cell culture, and so on. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, biomaterial, biomedical engineering, and environmental applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 100 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 22 patents, including two books from Elsevier on microfluidic devices for biomedical applications. He is an Advisory Board member of Lab on a Chip and Analyst, the Founder of microBioChip Diagnostics LLC, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the “Bioanalysis New Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award in 2009, and so on. For more information, please visit http://li.utep.edu.

Affiliations and Expertise

Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El Paso

Yu Zhou

Yu Zhou, PhD, is a Research Scientist in the Department of Research and Development at ABS Global Inc., USA. Dr Zhou received his Ph.D. degree in mechanical engineering from University of Illinois at Chicago in 2010. After graduation, he joined ABS Global, the world-leading genetics provider company as a key researcher and has been working on the development of a high-throughput microfluidic cytometry for biological cell detection and manipulation. He obtained extensive experience in design and fabrication of silicon-based microsystems and disposal plastic microfluidic chips, precision fluid delivery, and microfluidics-based single cell separation and analysis. He is a member of ASME and serves on the advisory editorial board for several technical journals including Microsystem Technologies, and Journal of Mechanical Engineering Research (Canada) since 2011.

Affiliations and Expertise

Department of R&D at ABS Global Inc., USA

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