Microbiome, Immunity, Digestive Health and Nutrition

Microbiome, Immunity, Digestive Health and Nutrition

Epidemiology, Pathophysiology, Prevention and Treatment

1st Edition - July 15, 2022

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  • Editors: Debasis Bagchi, Bernard Downs
  • Paperback ISBN: 9780128222386

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Microbiome, Immunity, Digestive Health and Nutrition: Epidemiology, Pathophysiology, Prevention and Treatment addresses a wide range of topics related to the role of nutrition in achieving and maintaining a healthy gut microbiome. Written by leading experts in the field, the book outlines the various foods, minerals, vitamins, dietary fibers, prebiotics, probiotics, nutritional supplements, phytochemicals and drugs that improve gut health. It specifically addresses molecular and cellular mechanisms and pathways by which these nutritional components contribute to the physiology and functionality of a healthy gut microbiome and gut health. Intended for nutrition researchers and practitioners, food experts, gastroenterologists, nurses, general practitioners, public health officials and health professionals, this book is sure to be a welcomed resource.

Key Features

  • Outlines the nutritional guidelines and healthy lifestyle that is important to boost gut health
  • Demonstrates the effects of diverse environmental stressors in the disruption of the gastrointestinal ecology
  • Discusses the molecular and immunological mechanisms associated with healthy gut microbiome functions
  • Addresses how to boost healthy gut microflora and microbiome
  • Suggests areas for future research of microbiome-based nutrition and therapies


Nutrition researchers and practitioners, food experts, gastroenterologists, nurses and general practitioners, public health officials, health professionals

Table of Contents

  • I. Preface
    From the Editor's Desk

    II. Microbiome and Human Health: An Introduction
    1. Oral Microbiome: A Gateway to Human Health
    2. Influence of Microbiome in Shaping the Newborn Immune System: An Overview
    3. Impact of Gut Bacteria on Human Health and Diseases
    4. Individual Microbiota Correction and Human Health: Programing and Reprogramming of Systemic and Local Immune Response

    III. Microbiome and Digestive Health
    5. The Etiology of Gut Dysbiosis and its Role in Chronic Disease
    6. Role of Microbiome in the Function and Diseases of the Digestive System

    IV. Microbiome and Metabolic Syndrome
    7. Beneficial Role of Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health
    8. The Role of the Intestinal Microbiota in Weight Loss
    9. Role of Microbial Metabolites in Cardiovascular and Human Health
    10. Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health: An Overview
    11. Potential Role of Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health
    12. Restoring Gut Biome Balance for Weight Loss: Clinical applications
    13. Harnessing Gut Friendly Microbiomes to Combat Metabolic Syndrome
    14. The Effect of Resveratrol-Mediated Gut Microbiota Remodeling on Metabolic Disorders

    V. Microbiome and Immune Health
    15. Microbiome, Immunity, Anaerobism, and Inflammatory Conditions: A Multifaceted Systems Biology Intervention
    16. Preclinical Data Supports the Strong Specificity and Advertised Ability to Mitigate Immune Reactions at Mucosal Sites
    VI. Microbiome and Cognitive Health
    17. Achieving Dopamine Homeostasis to Combat Brain-Gut Functional Impairment: Behavioral and Neurogenetic Correlates of Reward Deficiency Syndrome (RDS)
    18. Influence of Gut Microbial Flora in Body’s Serotonin Turnover and Its Associated Diseases
    19. The Connection Between Diet, Gut Microbes and Cognitive Decline
    20. Role of the Gut Microbiome in Rett Syndrome

    VII. Microbiome, Dermal Health and Wound Healing
    21. Skin Microbiota and its Role in Health and Disease with an Emphasis in Chronic Wound Development and Wound Healing

    VIII. Microbiome and Cancer
    22. Healthy Gut Microbiome in the Prevention of Colorectal Cancer

    IX. Microbiome, Arthritis and Multiple Sclerosis
    23. Regulatory Roles of the Microbiome in Arthritis, Fibromyalgia, and Multiple Sclerosis

    X. Environmental Pollutants and Gut Microbiome
    24. Microplastic Exposure and Gut Microbiome

    XI. Molecular and Immunological Mechanisms Associated with Healthy Gut Microbiome Functions
    25. Role of the Gut Microbiome and Probiotics for Tuberculosis Prevention and Management
    26. Lactic Acid Bacteria-Based Beverages in Promotion of Gastrointestinal Health
    27. Prospective role of prebiotics and probiotics on gut immunity
    28. Gut Brain Communication: A novel application of Probiotics
    29. Beneficial Effects of Flaxseed on Gut Microbiota
    30. Dietary Flavonoids and Gut Microbiota
    31. Role of Mushroom Polysaccharides in Improving Gut health and Prevent Associated Diseases

    XII. Microbiome and Immunomodulatory Peptides
    32. Food derived immunomodulatory peptides: Science to applications

    XIII. Study Design and Statistical Interpretation
    33. Clinical Intervention Study Design and Statistical Methodology: Statistical Approaches for Pre–Post Studies

    XIV. Commentary from the Editor's Desk
    34. Conclusion and Editor's Commentary

Product details

  • No. of pages: 552
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 15, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128222386

About the Editors

Debasis Bagchi

Debasis Bagchi
Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Affiliations and Expertise

Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USA

Bernard Downs

Bernard William (Bill) Downs received his Bachelor of Science degree in 1975 from Pennsylvania State University. Downs simultaneously pursued his master’s degree and Ph.D. in Nutrition and Biochemistry at Immaculata University in Immaculata, PA; advanced degree not completed. He became Director of Therapeutic Nutrition for Morrison Family and Sports Medicine, Huntingdon Valley, PA from 1990 till 1996. Downs served as the Director of Technical Sales for InterHealth Nutraceuticals Inc., Benicia, CA from 1990 till 2003. He was the Director of Research and Development for Allied Nutraceutical Research, Blue Bell, PA, from 2003 till 2008. Downs served as the CEO of LifeGen Research from 2009 till 2013, Lederach, PA. Downs is Founder and CEO of Victory Nutrition International, Inc., a Research & Development Biotech Company, Lederach, PA. Downs is a member of the American Association for the Advancement of Science, the American College of Nutrition, and past member of the NY Academy of Sciences. He is on the editorial review board of the Journal of Reward Deficiency Syndrome. Downs has authored or co-authored 105 papers published in peer-reviewed journals, numerous chapters in texts and handbooks for clinicians and researchers, with patents-pending in nutraceutical biotechnology. Research publications have been on issues ranging from immunity, anemia and metabolic disorders to addictions, obsessions, compulsions, and personality disorders, among other Reward Deficiency Syndrome conditions.

Affiliations and Expertise

Founder, Victory Nutrition International, Inc., Lederach, Pennsylvania; CEO,Victory Nutrition International, Inc., Lederach, Pennsylvania, USA

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