Human Lymphokines

Human Lymphokines

The Biological Immune Response Modifiers

1st Edition - January 1, 1982

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  • Editor: Amanullah Khan
  • eBook ISBN: 9780323142670

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Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.

Table of Contents

  • Contributors



    I. Assay Systems: Standardization and Nomenclature

    Polyclonal B Cell Activator in Rheumatic Diseases

    Interferon Activates Macrophages to Produce Plasminogen Activator

    A Standardized Automated Computer Assisted Micro-Assay for Lymphotoxin

    Problems Associated with Research on Human MIF

    The Motility of the Cells of a Lymphoblastoid Cell, QIMR-WIL, Is Inhibited by Human and Murine Leukocyte Inhibitory Factor

    A Standardized and Rapid MIF Assay Using U-937 Cell Line and Optical Density Measurement

    Macrophage Activation by Lymphokine Factors (MAF) as Measured by Phagocytosis, Metabolic Products, and Tumor Cell Cytotoxicity: Correlation of Multiparameter Functional Assays

    Standardization of the Indirect LIF Test by Reference to Lymphoid Cell-Line Lymphokine (LCL-LK) as a Standard Material

    Value of Reference Preparations in Lymphokine Tests

    Semimicromodification of the Indirect Migration Inhibition / MIF Production / Test

    II. Production And Purification

    Induction and Augmentation of Mitogen-Induced Lymphokine Production in Human PBL by Nα-Desacetylthymosin α1

    Production of Human Interleukin-2(TCFG) Using Serum Free Culture Conditions

    Morphological Characteristics of Interferon-Producing Cells in Human Peripheral Blood

    Rapid Production of High Levels of Gamma Interferon by Human Thoracic Duct Leukocytes Stimulated with Staphylococcal Enterotoxin A

    Gamma (Immune) Interferon Production by a Permanent Human T-Lymphocyte Cell Line

    Purification of Lymphotoxin from RPMI-1788 Cell Line Supernate

    The Identification of Two New Classes of Lymphotoxin Released by Lectin Activated Human T Lymphocytes that Possess IG-Like Receptors

    Purification of the Alpha-Heavy Class of Human Lymphotoxin to Electrophoretic Homogeneity

    Production of Leucocyte Migration Inhibitory Factor (LIF) by Human Natural Killer (NK) Cells

    Spontaneous Production of Leucocyte Migration Inhibitory Factor (LIF) by Established Human Lymphoid Cell Lines

    Lymphokine Induced Release of Basophilic Histamine: Separation of the Activity into Two Factors

    The Physiological Interferon Response: The Sites and the Meaning

    Interferons Induced in Human Leukocytes by Mitogens: Production, Partial Purification, and Characterization

    III. Biological and Chemical Characterization

    Human Interleukin 1: Purification and Properties

    Human (T, G)-A—L Specific Helper Factors Possess VH as Well as HLA-DR Determinants

    Production and Characterization of Human Gamma Interferon

    Human Lymphocyte Production to Neuroendocrine Hormone-Related Substances

    Neutrophil Migration Inhibition Factor from T-Lymphocytes (NIF-T): Specific Binding to Human Peripheral Blood Neutrophils and Neutrophil Precursors

    Production and Biological Characterisation of Lymphoid Cell-Line Lymphokine (LCL-LK) Preparations

    Macrophage Agglutination Activity of Human Plasma Proteins

    Purification of Human Lymphokines by High Performance Liquid Chromatography

    Human Serum Factor Inducing Giant Fat Cell Formation in Human Bone Marrow Culture: Normal and Leukemic

    Human Leukocyte Interferon Comprises a Continuum of

    IV. Mechanisms of Action In Vitro and Animal Models

    Purification from the Serum of Patients with Rheumatoid Arthritis of a Polyclonal B Cell Activator with Esterase Activity and of Its Low Molecular Weight Inhibitor

    Resistance to Natural-Killer Cells' Cytotoxicity and HLA Synthesis: Differing Regulatory Efficiency of the Type-I and Immune Interferons

    Use of Cytofluorometric Techniques for Assay of Cell Cycle Regulating Lymphokines

    Lymphokine Adjuvant Therapy: Bioassay of Human Lymphokine Fractions in a Mouse Tumor Model

    The Species Specificity of Interleukin-2

    Effect of Human α-Lymphotoxin on Target-Cell Plasma Membranes

    Lymphotoxins: An NK-Like LT System

    Selective Lysis of Natural Killer (NK) Sensitive Targets by Soluble Cytotoxic Factors (NKCF)

    Phospholipase C Activity in Human Interferons

    Mechanisms of Induction of Human Gamma Interferon

    Enhancement of Natural Killing Activity by Different Types of Interferon

    V. Immunoregulatory Effects

    Genetic Regulation of the Immune Response to (T,G)-A—L in the Human

    Induction of Concanavalin-A (Con-A) Stimulated Suppressive Factors in Acute Lymphocytic Leukemia (ALL)

    Angiogenic Lymphokine from Transformed Lymphocytes. A Key to the Underlying Mechanisms in Angiolymphoproliferative Syndromes (ALPS)

    Regulatory Aspects of LIF Production by Con-A Stimulated MNC Cultures

    Cystic Fibrosis: Further Characterization of a "New" Cytokine which Modulates Neutrophil and Monocyte Chemotaxis

    VI. Clinical Experience

    Pre-Clinical and Phase


    Systematic Lymphokine Treatment of Selected Cancer Patients

    Hormonal, Haematological, and Acute Phase Protein Responses of Advanced Cancer Patients to the Intravenous Injection of Lymphoid-Cell Lymphokine (LCL-LK)

    A Histological Study of Intradermal and Intralesional Injection of Human Lymphoid Cell Line Lymphokine (LCL-LK) in Patients with Advanced Cancer

    The Monitoring of the Immunosuppressive Therapy of Systemic Lupus Erythematosus by Means of the MIF Production Test



Product details

  • No. of pages: 756
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 1, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323142670

About the Editor

Amanullah Khan

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