Human Lymphokines - 1st Edition - ISBN: 9780124060807, 9780323142670

Human Lymphokines

1st Edition

The Biological Immune Response Modifiers

Editors: Amanullah Khan
eBook ISBN: 9780323142670
Imprint: Academic Press
Published Date: 1st January 1982
Page Count: 756
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Description

Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.

Table of Contents


Contributors

Preface

Acknowledgments

I. Assay Systems: Standardization and Nomenclature

Polyclonal B Cell Activator in Rheumatic Diseases

Interferon Activates Macrophages to Produce Plasminogen Activator

A Standardized Automated Computer Assisted Micro-Assay for Lymphotoxin

Problems Associated with Research on Human MIF

The Motility of the Cells of a Lymphoblastoid Cell, QIMR-WIL, Is Inhibited by Human and Murine Leukocyte Inhibitory Factor

A Standardized and Rapid MIF Assay Using U-937 Cell Line and Optical Density Measurement

Macrophage Activation by Lymphokine Factors (MAF) as Measured by Phagocytosis, Metabolic Products, and Tumor Cell Cytotoxicity: Correlation of Multiparameter Functional Assays

Standardization of the Indirect LIF Test by Reference to Lymphoid Cell-Line Lymphokine (LCL-LK) as a Standard Material

Value of Reference Preparations in Lymphokine Tests

Semimicromodification of the Indirect Migration Inhibition / MIF Production / Test

II. Production And Purification

Induction and Augmentation of Mitogen-Induced Lymphokine Production in Human PBL by Nα-Desacetylthymosin α1

Production of Human Interleukin-2(TCFG) Using Serum Free Culture Conditions

Morphological Characteristics of Interferon-Producing Cells in Human Peripheral Blood

Rapid Production of High Levels of Gamma Interferon by Human Thoracic Duct Leukocytes Stimulated with Staphylococcal Enterotoxin A

Gamma (Immune) Interferon Production by a Permanent Human T-Lymphocyte Cell Line

Purification of Lymphotoxin from RPMI-1788 Cell Line Supernate

The Identification of Two New Classes of Lymphotoxin Released by Lectin Activated Human T Lymphocytes that Possess IG-Like Receptors

Purification of the Alpha-Heavy Class of Human Lymphotoxin to Electrophoretic Homogeneity

Production of Leucocyte Migration Inhibitory Factor (LIF) by Human Natural Killer (NK) Cells

Spontaneous Production of Leucocyte Migration Inhibitory Factor (LIF) by Established Human Lymphoid Cell Lines

Lymphokine Induced Release of Basophilic Histamine: Separation of the Activity into Two Factors

The Physiological Interferon Response: The Sites and the Meaning

Interferons Induced in Human Leukocytes by Mitogens: Production, Partial Purification, and Characterization

III. Biological and Chemical Characterization

Human Interleukin 1: Purification and Properties

Human (T, G)-A—L Specific Helper Factors Possess VH as Well as HLA-DR Determinants

Production and Characterization of Human Gamma Interferon

Human Lymphocyte Production to Neuroendocrine Hormone-Related Substances

Neutrophil Migration Inhibition Factor from T-Lymphocytes (NIF-T): Specific Binding to Human Peripheral Blood Neutrophils and Neutrophil Precursors

Production and Biological Characterisation of Lymphoid Cell-Line Lymphokine (LCL-LK) Preparations

Macrophage Agglutination Activity of Human Plasma Proteins

Purification of Human Lymphokines by High Performance Liquid Chromatography

Human Serum Factor Inducing Giant Fat Cell Formation in Human Bone Marrow Culture: Normal and Leukemic

Human Leukocyte Interferon Comprises a Continuum of

IV. Mechanisms of Action In Vitro and Animal Models

Purification from the Serum of Patients with Rheumatoid Arthritis of a Polyclonal B Cell Activator with Esterase Activity and of Its Low Molecular Weight Inhibitor

Resistance to Natural-Killer Cells' Cytotoxicity and HLA Synthesis: Differing Regulatory Efficiency of the Type-I and Immune Interferons

Use of Cytofluorometric Techniques for Assay of Cell Cycle Regulating Lymphokines

Lymphokine Adjuvant Therapy: Bioassay of Human Lymphokine Fractions in a Mouse Tumor Model

The Species Specificity of Interleukin-2

Effect of Human α-Lymphotoxin on Target-Cell Plasma Membranes

Lymphotoxins: An NK-Like LT System

Selective Lysis of Natural Killer (NK) Sensitive Targets by Soluble Cytotoxic Factors (NKCF)

Phospholipase C Activity in Human Interferons

Mechanisms of Induction of Human Gamma Interferon

Enhancement of Natural Killing Activity by Different Types of Interferon

V. Immunoregulatory Effects

Genetic Regulation of the Immune Response to (T,G)-A—L in the Human

Induction of Concanavalin-A (Con-A) Stimulated Suppressive Factors in Acute Lymphocytic Leukemia (ALL)

Angiogenic Lymphokine from Transformed Lymphocytes. A Key to the Underlying Mechanisms in Angiolymphoproliferative Syndromes (ALPS)

Regulatory Aspects of LIF Production by Con-A Stimulated MNC Cultures

Cystic Fibrosis: Further Characterization of a "New" Cytokine which Modulates Neutrophil and Monocyte Chemotaxis

VI. Clinical Experience

Pre-Clinical and Phase

Phase

Systematic Lymphokine Treatment of Selected Cancer Patients

Hormonal, Haematological, and Acute Phase Protein Responses of Advanced Cancer Patients to the Intravenous Injection of Lymphoid-Cell Lymphokine (LCL-LK)

A Histological Study of Intradermal and Intralesional Injection of Human Lymphoid Cell Line Lymphokine (LCL-LK) in Patients with Advanced Cancer

The Monitoring of the Immunosuppressive Therapy of Systemic Lupus Erythematosus by Means of the MIF Production Test

Phase

Index


Details

No. of pages:
756
Language:
English
Copyright:
© Academic Press 1982
Published:
Imprint:
Academic Press
eBook ISBN:
9780323142670

About the Editor

Amanullah Khan

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