Hematopathology

Hematopathology

2nd Edition - June 27, 2016

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  • Authors: Elaine Jaffe, Daniel Arber, Elias Campo, Leticia Quintanilla-Martinez, Attilio Orazi
  • eBook ISBN: 9780323388719

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Description

The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike.

Key Features

  • Authored by the chief architects of the WHO classification in neoplasms of hematopoietic and lymphoid tissue.
  • Covers the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies.
  • Confirm or challenge your diagnostic interpretations by comparing specimens to over 1,000 high-quality color images.

Table of Contents

  • Contents


    Part I: TECHNICAL ASPECTS
    1. Processing of the Lymph Node Biopsy Specimen   
    2. Fine Needle Aspiration of Lymph Nodes   
    3. Collection, Processing, and Examination of Bone Marrow Specimens
    4. Immunohistochemistry for the Hematopathology Laboratory
    5. Flow Cytometry   
    6. Molecular Diagnosis in Hematopathology
    7. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them  

    Part II: NORMAL and REACTIVE CONDTIONS of HEMATOPOIETIC TISSUES

    8. Normal Lymphoid Organs and Tissues
    9. The Reactive Lymphadenopathies
    10. The Normal Bone Marrow
    11. Evaluation of Anemia, Leukopenia, and Thrombocytopenia
    12. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders

    Part III: LYMPHOID NEOPLASMS

    13. Principles of Classification of Lymphoid Neoplasms

    Section 1: Mature B-Cell Neoplasms

    14. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia
    15. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
    16. Hairy Cell Leukemia
    17. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen 
    18. Follicular Lymphoma
    19. Extranodal Marginal Zone Lymphoma: MALT Lymphoma
    20. Primary Cutaneous B-Cell Lymphomas
    21. Nodal Marginal Zone Lymphoma
    22. Mantle Cell Lymphoma
    23. Diffuse Large B-Cell Lymphoma
    24. Burkitt Lymphoma and its Mimics
    25. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
    26. Plasma Cell Neoplasms
    27. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma
    28. Classical Hodgkin's Lymphoma and Related Lesions
    29. Virally Associated B-Cell Lymphoproliferative Disease

    Section 2: MATURE T-CELL AND NK-CELL NEOPLASMS

    30. Virally Associated T-Cell and NK-Cell Neoplasms
    31. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
    32. T-Cell Prolymphocytic Leukemia
    33. Adult T-Cell Leukemia/Lymphoma
    34. Hepatosplenic T-Cell Lymphoma
    35. Peripheral T-Cell Lymphoma, Not Otherwise Specified
    36. Angioimmunoblastic T-Cell Lymphoma
    37. Anaplastic Large-Cell Lymphoma, ALK Positive and ALK Negative
    38. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
    39. Mycosis Fungoides and Sézary Syndrome
    40. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
    41. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes

    Section 3: Precursor B- and T-Cell Neoplasms

    42. Precursor B- and T-Cell Neoplasms
    43. Acute Leukemias of Ambiguous Lineage

    Part IV: MYELOID NEOPLASMS

    44. Principles of Classification of Myeloid Neoplasms
    45. The Myelodysplastic Syndromes
    46. Acute Myeloid Leukemia
    47. Myeloproliferative Neoplasms
    48. Myelodysplastic/Myeloproliferative Neoplasms
    49. Mastocytosis
    50. Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2
    51. Blastic Plasmacytoid Dendritic Cell Neoplasm

    Part V: HISTIOCYTIC PROLIFERATIONS

    52. Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow
    53. Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

    Part VI: IMMUNODEFICIENCY DISORDERS

    54. The Pathology of Primary Immunodeficiencies
    55. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder

    Part VII: SITE-SPECIFIC ISSUES in the DIAGNOSIS of LYMPHOMA and LEUKEMIA

    56. Bone Marrow Evaluation for Lymphoma
    57. Evaluation of the Bone Marrow After Therapy
    58. Non-Hematopoietic Neoplasms of the Bone Marrow
    59. Nonlymphoid Lesions of the Lymph Nodes
    60. Spleen: Normal Architecture and Neoplastic and Nonneoplastic Lesions
    61. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

Product details

  • No. of pages: 1216
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: June 27, 2016
  • Imprint: Elsevier
  • eBook ISBN: 9780323388719

About the Authors

Elaine Jaffe

Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard.

Affiliations and Expertise

Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland

Daniel Arber

Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen.

Affiliations and Expertise

Professor and Chair of Pathology, University of Chicago School of Medicine, USA

Elias Campo

the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium.

Affiliations and Expertise

Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain

Leticia Quintanilla-Martinez

Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks.

Affiliations and Expertise

Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, Germany

Attilio Orazi

Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.

Affiliations and Expertise

Chair, Department of Pathology Paul L. Foster School of Medicine Texas Tech University Health Sciences Center 4625 Alberta Avenue El Paso TX 79905 USA

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