Hematopathology - 2nd Edition - ISBN: 9780323296137, 9780323388726

Hematopathology

2nd Edition

Authors: Elaine Jaffe Daniel Arber Elias Campo Leticia Quintanilla-Fend Attilio Orazi
Hardcover ISBN: 9780323296137
eBook ISBN: 9780323388726
eBook ISBN: 9780323388719
Imprint: Elsevier
Published Date: 25th August 2016
Page Count: 1216
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Description

The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike.

Key Features

  • Authored by the chief architects of the WHO classification in neoplasms of hematopoietic and lymphoid tissue.
  • Covers the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies.
  • Confirm or challenge your diagnostic interpretations by comparing specimens to over 1,000 high-quality color images.

Table of Contents

Contents


Part I: TECHNICAL ASPECTS
1. Processing of the Lymph Node Biopsy Specimen   
2. Fine Needle Aspiration of Lymph Nodes   
3. Collection, Processing, and Examination of Bone Marrow Specimens
4. Immunohistochemistry for the Hematopathology Laboratory
5. Flow Cytometry   
6. Molecular Diagnosis in Hematopathology
7. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them  

Part II: NORMAL and REACTIVE CONDTIONS of HEMATOPOIETIC TISSUES

8. Normal Lymphoid Organs and Tissues
9. The Reactive Lymphadenopathies
10. The Normal Bone Marrow
11. Evaluation of Anemia, Leukopenia, and Thrombocytopenia
12. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders

Part III: LYMPHOID NEOPLASMS

13. Principles of Classification of Lymphoid Neoplasms

Section 1: Mature B-Cell Neoplasms

14. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and B-Cell Prolymphocytic Leukemia
15. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
16. Hairy Cell Leukemia
17. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen 
18. Follicular Lymphoma
19. Extranodal Marginal Zone Lymphoma: MALT Lymphoma
20. Primary Cutaneous B-Cell Lymphomas
21. Nodal Marginal Zone Lymphoma
22. Mantle Cell Lymphoma
23. Diffuse Large B-Cell Lymphoma
24. Burkitt Lymphoma and its Mimics
25. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
26. Plasma Cell Neoplasms
27. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma
28. Classical Hodgkin's Lymphoma and Related Lesions
29. Virally Associated B-Cell Lymphoproliferative Disease

Section 2: MATURE T-CELL AND NK-CELL NEOPLASMS

30. Virally Associated T-Cell and NK-Cell Neoplasms
31. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
32. T-Cell Prolymphocytic Leukemia
33. Adult T-Cell Leukemia/Lymphoma
34. Hepatosplenic T-Cell Lymphoma
35. Peripheral T-Cell Lymphoma, Not Otherwise Specified
36. Angioimmunoblastic T-Cell Lymphoma
37. Anaplastic Large-Cell Lymphoma, ALK Positive and ALK Negative
38. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
39. Mycosis Fungoides and Sézary Syndrome
40. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
41. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes

Section 3: Precursor B- and T-Cell Neoplasms

42. Precursor B- and T-Cell Neoplasms
43. Acute Leukemias of Ambiguous Lineage

Part IV: MYELOID NEOPLASMS

44. Principles of Classification of Myeloid Neoplasms
45. The Myelodysplastic Syndromes
46. Acute Myeloid Leukemia
47. Myeloproliferative Neoplasms
48. Myelodysplastic/Myeloproliferative Neoplasms
49. Mastocytosis
50. Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2
51. Blastic Plasmacytoid Dendritic Cell Neoplasm

Part V: HISTIOCYTIC PROLIFERATIONS

52. Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow
53. Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Part VI: IMMUNODEFICIENCY DISORDERS

54. The Pathology of Primary Immunodeficiencies
55. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder

Part VII: SITE-SPECIFIC ISSUES in the DIAGNOSIS of LYMPHOMA and LEUKEMIA

56. Bone Marrow Evaluation for Lymphoma
57. Evaluation of the Bone Marrow After Therapy
58. Non-Hematopoietic Neoplasms of the Bone Marrow
59. Nonlymphoid Lesions of the Lymph Nodes
60. Spleen: Normal Architecture and Neoplastic and Nonneoplastic Lesions
61. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

Details

No. of pages:
1216
Language:
English
Copyright:
© Elsevier 2017
Published:
25th August 2016
Imprint:
Elsevier
Hardcover ISBN:
9780323296137
eBook ISBN:
9780323388726
eBook ISBN:
9780323388719

About the Authors

Elaine Jaffe

Dr. Elaine Jaffe is regarded by her peers as one of the most pre-eminent hematopathologists of her generation. She is most widely known for her work regarding the pathophysiology and prognosis of malignant lymphomas, as well as her unparalleled work to understand how they respond to treatment. Dr. Jaffe led the effort to develop the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues published in 2001, a classification that rapidly became the international standard.

Affiliations and Expertise

Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland

Daniel Arber

Dr. Daniel Arber is an internationally recognized expert in the diagnosis and classification of hematopoietic tumors, including malignant lymphoma, acute and chronic leukemia, myeloproliferative disorders, myelodysplastic syndrome and tumors of the spleen.

Affiliations and Expertise

Professor and Chair of Pathology, University of Chicago School of Medicine, USA

Elias Campo

the clinical director of the Biomedical Diagnostic Centre of Hospital Clinic and a full Professor of Anatomical Pathology at the University of Barcelona, where he also teaches in the Department of Anatomical Pathology, Pharmacy and Microbiology. He is the Spanish coordinator of the International Cancer Genome Consortium.

Affiliations and Expertise

Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain

Leticia Quintanilla-Fend

Professor Dr. Leticia Quintanilla de Fend, head of the Core Facility and Senior Physician at the Institute of Pathology has extensive experience in the interpretation of mouse models. From 2000 until 2008 she was a director of the mouse pathology at the Institute of Pathology of the Helmholtz Center Munich and the Pathology Screen of the German Mouse Clinic (GMC) and established various special procedures for the analysis of mouse models. Professor Quintanilla de Fend is involved in the establishment of standards in the pathology of mouse models within EU networks.

Affiliations and Expertise

Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, Germany

Attilio Orazi

Dr. Attilio Orazi is an internationally renowned academic hematopathologist whose diagnostic expertise spans all areas of hematopathology. However, he is best known for his expertise and scholarly accomplishments as a bone marrow pathologist. He is a member of the Scientific Committee of the European Bone Marrow Working Group, has directed courses concerning the assessment of bone marrow disorders and splenic pathology at the United States and Canadian Academy of Pathology and was the co-organizer of the 2007 Workshop of the Society of Hematopathology.

Affiliations and Expertise

Chair, Department of Pathology Paul L. Foster School of Medicine Texas Tech University Health Sciences Center 4625 Alberta Avenue El Paso TX 79905 USA