Handbook of Neuro-Oncology Neuroimaging

Handbook of Neuro-Oncology Neuroimaging

2nd Edition - April 2, 2016

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  • Editor: Herbert Newton
  • eBook ISBN: 9780128011683
  • Hardcover ISBN: 9780128009451

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Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment. With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Key Features

  • Provides a background to translational research and the use of brain imaging for brain tumors
  • Contains critical discussions on the potential and limitations of neuroimaging as a translational tool for the diagnosis and treatment of brain tumor and neuro-oncology patients
  • Presents an up-to-date reference on advanced imaging technologies, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), as well as the recent refinements in these techniques


Neurosurgeons, neuro-oncologists, neuroradiologists, oncologists, neurologists, and researchers (within oncology and radiology) with an interest in neuroimaging and neuro-oncology

Table of Contents

  • Section I.  Overview of Neuro-Oncological Disorders
    1. Overview of Brain Tumor Epidemiology
      Herbert B. Newton
    2. Overview of Pathology and Treatment of Primary Brain Tumors
      Herbert B. Newton
    3. Overview of Pathology and Treatment of Metastatic Brain Tumors
      Herbert B. Newton
    4. Overview of Spinal Cord Tumor Epidemiology
      Herbert B. Newton
    5. Overview of Pathology and Treatment of Primary Spinal Cord Tumors
      Herbert B. Newton
    6. Overview of Pathology and Treatment of Intramedullary Spinal Cord Metastases
      Herbert B. Newton
    7. Epidural Spinal Cord Compression in Adult Neoplasms
      Alicia M. Zukas and David Schiff
    8. Neoplastic Meningitis
      Sophie Taillibert, Emilie Le Rhun and Marc C. Chamberlain
    9. Vascular Disorders: Epidemiology
      Sylvia Eisele and Lisa Rogers
    10. Intracranial Hemorrhage in Cancer Patients
      Chaitra A. Badve and Lisa Rogers
    11. CNS Infarction
      Achala Vagal, Arastoo Vossough, Michael H. Lev and Max Wintermark
    12. Intracranial Veno-Occlusive Disease
      Chaitra A. Badve and Lisa Rogers
    13. Paraneoplastic Syndromes
      Ugonma Chukwueke and Steven Vernino
    14. Neoplastic Plexopathies
      Mark A. Ferrante and John T. Kissel
    15. Neurologic Complications of Oncologic Therapy
      Isabel Arrillaga-Romany, Michelle Monje and Patrick Wen

    Section II.  Physics and Basic Science of Neuro-Imaging
    16. Physics of CT: Scanning
      Johannes T. Heverhagen
    17. Physics of CT: Contrast Agents
      Ingrid Boehm and Johannes T. Heverhagen
    18. Introductory MRI Physics
      Aaron Sodickson and Daniel Sodickson
    19. Advanced MR Imaging of Brain Tumors
      Geoffrey S. Young and Jinrong Qu
    20. MR Contrast Agents for Neuroradiology: Current Status
      Genevieve Bolles and Maria Vittoria Spampinato
    21. Physics of High Field MRI and Applications to Brain Tumor Imaging
      Alayar Kangarlu

    Section III.  Advances in Neuro-Imaging of Brain Tumors
    22. Magnetic Resonance Image Guided Neurosurgery
      Ferenc Jolesz
    23. Neurosurgical Treatment Planning
      Wenya Linda Bi, Olutayo I. Olubiyi, Suzanne Tharin and Alexandra Golby
    24. Use of Neuro-Imaging for Radiation Therapy Planning
      Lonika Majithia, Steve Walston, Michael Guiou, Nilendu Gupta and Arnab Chakravarti
    25. TTFields Therapy:  Preclinical and Clinical Data
      Joshua Lantos, Robert J. Young, Pedro Cavaleiro Miranda, Cornelia Wenger and Eric T. Wong
    26. Applications of Stereotactic Radiosurgery in Neuro-Oncology
      Kunal S. Patel, Paul H. Chapman, Marc Bussiere, Jay Loeffler and Clark C. Chen
    27. Diffusion Magnetic Resonance Imaging in Brain Tumors
      L. Celso Hygino da Cruz, Jr. and Margareth Kimura
    28. Diffusion Imaging of Brain Tumors
      Stephan E. Maier
    29. Functional MRI
      Ryan Fisicaro, Nicole M. Petrovich Brennan and Andrei I. Holodny
    30. Magnetic Resonance Spectroscopy
      Tom Mikkelsen, James Snyder and David Hearshen
    31. Perfusion Imaging for Brain Tumor Characterization and Assessment of Treatment Response
      Kathleen Schmainda
    32. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Physics
      Marie Foley Kijewski
    33. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Imaging
      Randy Yeh, Vesselin Z. Miloushev and Masanori Ichise
    34. Methionine PET - Overview and Application to Brain Tumor Imaging and Treatment
      Arash Kardan and Martin Satter
    35. Ultra-High Field Magnetic Resonance Imaging of Brain Tumors
      Gregory A. Christoforidis
    36. Neuroimaging of Brain Tumors in Animal Models of CNS Cancer
      Y. Sun and Herbert B. Newton
    37. RANO Criteria:  Application to Response Assessment in Clinical Trials 
      Mithun G. Sattur and Michael A. Vogelbaum

    Section IV.  Neuro-Imaging of Brain Tumors
    38. Malignant Astrocytomas
      A. Drevelegas, D. Chourmouzi, N. Papanicolaou and K. Drevelegas
    39. Low Grade Astrocytomas
      John M. Collins and Gregory A. Christoforidis
    40. Imaging of Oligodendrogliomas
      William Ankenbrandt and Nina A. Paleologos
    41. Primary Central Nervous System Lymphoma
      Herbert B. Newton, H. Wayne Slone and Eric C. Bourekas
    42. Pituitary and Sellar region Lesions
      Eric C. Bourekas, Lilja Bjork Solnes and H. Wayne Slone
    43. Neoplasms of the Cranial Nerves
      Nicholas C. Ferraro, Michael E. Ivan and Ricardo Jorge Komotar
    44. Meningeal tumors
      John M. Collins and Gregory A. Christoforidis
    45. Intracranial Schwannomas
      D. Bradley Welling
    46. Diencephalic and other deep brain tumors
      A. Drevelegas, D. Chourmouzi, E. Xinou and K. Drevelegas
    47. Neuro-Imaging of Glioneuronal Tumors
      Priya Kumthekar and Jeffrey J. Raizer
    48. Pineal region tumors
      Edward Yang, Susan Chi and Victoria Michelle Silvera
    49. Chordomas and other skull base tumors
      Eric C. Bourekas, Herbert B. Newton and H. Wayne Slone
    50. Pediatric brain tumors
      Sanjay P. Prabhu and Tina Y. Poussaint
    51. Papillary Glioneuronal Tumors
      Herbert B. Newton, H. Wayne Slone and Eric C. Bourekas
    52. Intracranial Metastases
      Arastoo Vossough and John W. Henson
    53. Non-Neoplastic mass lesions of the CNS
      S.B. Omay, A. Komli-Kofi and Joachim M. Baehring
    54. Neuroimaging Issues in Assessing Response to Brain Tumor Therapy
      Brendan McCullough and John W. Henson
    55. Pseudoprogression in Neuro-Oncology: Overview, Pathophysiology, and Interpretation
      Nancy Ann Oberheim Bush, Soonmee Cha, Susan Chang and Jennifer Clarke
    56. Pitfalls in the Neuroimaging of Brain Tumors
      Eric C. Bourekas and H. Wayne Slone

    Section V.  Neuro-Imaging of Other Neuro-Oncological Syndromes
    57. Neuroradiology of Leptomeningeal Metastases
      Emilie Le Rhun, Sophie Taillibert and Marc C. Chamberlain
    58. Imaging of Epidural Spinal Cord Compression
      Max Wintermark, David Schiff and Tanvir Rizvi
    59. Neuro-imaging for Surgical Treatment Planning of Neoplastic Disease of the Spine
      Carlos Goulart, Tobias A. Mattei, Michael A. Weicker and Ehud Mendel
    60. Imaging of Plexopathy in Oncologic Patients
      Andrew D. Schweitzer and George Krol
    61. Imaging of Peripheral Neurogenic Tumors
      Randall Lawrence Baldassarre, Ken Alexander Nakanote and Tudor Hesketh Hughes
    62. Neuro-Imaging of Cerebrovascular Complications in Cancer Patients
      Prashant Nagpal and Rajan Jain
    63. Neuroimaging of Paraneoplastic Syndromes
      Justin Jordan and Steven Vernino

Product details

  • No. of pages: 864
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: April 2, 2016
  • Imprint: Academic Press
  • eBook ISBN: 9780128011683
  • Hardcover ISBN: 9780128009451

About the Editor

Herbert Newton

Herbert Newton
Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.

Affiliations and Expertise

Director, Neuro-Oncology Center, Medical Director, CNS Oncology Program, Advent Health Cancer Institute, Advent Health Orlando, Campus & Advent Health Medical Group, Professor of Neurology, UCF School of Medicine, Orlando, FL, USA

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