Fermentation and Biochemical Engineering Handbook

3rd Edition

Editors: Celeste M. Todaro Henry C. Vogel
Hardcover ISBN: 9781455725533
eBook ISBN: 9781455730469
Imprint: William Andrew
Published Date: 25th March 2014
Page Count: 454
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A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, Fermentation and Biochemical Engineering Handbook emphasizes the operation, development and design of manufacturing processes that use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes—data collection, scale-up parameters, equipment selection, troubleshooting, and more. They also provide relevant perspectives for the different industry sectors utilizing fermentation techniques, including chemical, pharmaceutical, food, and biofuels.

New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes, and in situ real-time fermentation monitoring with wireless technology. It addresses topical environmental considerations, including the use of new (bio)technologies to treat and utilize waste streams and produce renewable energy from wastewaters. Options for bioremediation are also explained.

Key Features

  • Fully updated to cover the latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery, along with developments in instrumentation
  • Industrial contributors from leading global companies, including Merck, Eli Lilly, Amgen, and Bristol-Myers Squibb
  • Covers synthetic processes for both small and large molecules


Engineers and scientists in the chemical and pharmaceutical industries who use fermentation techniques in production. Development, design, engineering and production personnel in the fermentation industry. 

Table of Contents

  • Dedication
  • Preface to the Third Edition
  • Preface to the Second Edition
  • Preface to the First Edition
  • In Memory of Henry C. Vogel
  • List of Contributors
  • Part I: Fermentation

    • Chapter 1. Fermentation Pilot Plant

      • Prologue
      • 1.0 Microbial Fermentation
      • Further Reading
    • Chapter 2. Mammalian Cell Culture System

      • 1.0 Introduction
      • 2.0 Culture Media
      • 3.0 Microcarrier Culture and General Control Parameters
      • 4.0 Perfusion Culture Systems as a New High Density Culture Technology
      • 5.0 Sedimentation Column Perfusion Systems
      • 6.0 High Density Culture Using a Perfusion Culture System with Sedimentation Column
      • Acknowledgment
      • References and Bibliography (Section 2)
      • Further Reading
    • Chapter 3. Bioreactors for Plant Cell Tissue and Organ Cultures

      • 1.0 Background of the Technique—Historical Overview
      • 2.0 Media Formulations
      • 3.0 General Applications
      • 4.0 Bioreactors—Hardware Configuration
      • 5.0 Bioreactor Size
      • 6.0 Culture Period
      • 7.0 Aeration and Agitation
      • 8.0 Microbial Contamination
      • 9.0 Characteristics
      • 10.0 Manipulation
      • 11.0 Scale-up Problems
      • 12.0 Bioprocess Measurement and Control
      • References (Section 3)
      • Further Reading
    • Chapter 4. Nutritional Requirements in Fermentation Processes

      • 1.0 Introduction
      • 2.0 Nutritional Requirements of the Cell
      • 3.0 The Carbon Source
      • 4.0 The Nitrogen and Sulfur Source
      • 5.0 The Source of Trace and Essential Elements
      • 6.0 The Vitamin Source and Other Growth Factors
      • 7.0 Physical and Ionic Requirements
      • 8.0 Media Development
      • 9.0 Effect of Nutrient Concentration on Growth Rate
      • References
      • Further Reading
    • <


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© William Andrew 2014
William Andrew
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About the Editor

Celeste M. Todaro

Henry C. Vogel