Engineered Nanoparticles
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Engineered Nanoparticles

Structure, Properties and Mechanisms of Toxicity

1st Edition - November 24, 2015

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  • Author: Ashok Singh
  • Paperback ISBN: 9780128014066
  • eBook ISBN: 9780128014929

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Description

Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects.

Key Features

  • Provides state-of-the-art physicochemical descriptions and methodologies for the characterization of engineered nanomaterials (ENM)
  • Describes the potential toxicological effects of ENM and the nanotoxicological mechanisms of action
  • Presents how to apply theory to practice in a public health and risk assessment setting

Readership

Toxicologists, risk assessors, graduate and postgraduate students in toxicology, public health and nanotechnology.

Table of Contents

    • Dedication
    • Foreword
    • Chapter 1. Introduction to Nanoparticles and Nanotoxicology
      • 1. Introduction to Nanoparticles
      • 2. Introduction to Nanotoxicology
      • 3. Conclusions
    • Chapter 2. Structure, Synthesis, and Application of Nanoparticles
      • 1. Introduction
      • 2. Metal, Semiconductor, and Quantum Dot Nanoparticles
      • 3. Carbon Nanotubes and Fullerenes
      • 4. Linear Nanopolymers
      • 5. Dendrimer Nanoparticles
      • 6. Conclusions
      • 7. Appendices
    • Chapter 3. Physicochemical, Electronic, and Mechanical Properties of Nanoparticles
      • 1. Common Size and Surface-Related Properties
      • 2. Physicochemical Properties of Specific Nanoparticles
      • 3. Conclusions
      • 4. Appendices
    • Chapter 4. Experimental Methodologies for the Characterization of Nanoparticles
      • 1. Introduction
      • 2. Nanoparticle Enumeration, Size, and Shape
      • 3. Chemical Analysis of Nanoparticles
      • 4. Surface Analysis
      • 5. Physiochemical Properties
      • 6. Magnetic Properties
      • 7. Thermodynamic Characterization
      • 8. Conclusions
    • Chapter 5. Principles of Nanotoxicology
      • 1. Historical Perspectives
      • 2. Classic Toxicology
      • 3. The Principles of Classic Toxicology and Nanotoxicology
      • 4. Nanoparticle Exposure
      • 5. Nano-Bio Interface
      • 6. Bioavailability and Biodistribution of Nanoparticles
      • 7. The Target Tissue/Organ
      • 8. Conclusions
    • Chapter 6. Nanoparticle Pharmacokinetics and Toxicokinetics
      • 1. Introduction
      • 2. Absorption, Distribution, Metabolism, and Elimination
      • 3. Biokinetics
      • 4. Nanoparticle Biokinetics
      • 5. Conclusions
    • Chapter 7. Mechanisms of Nanoparticle Toxicity
      • 1. Introduction
      • 2. Overview of Toxicology
      • 3. Factors Determining Nanoparticle Toxicity
      • 4. Mechanisms of Nanoparticle Toxicity
      • 5. System/Organ Toxicity of Nanoparticles
      • 6. Conclusions
    • Chapter 8. Nanoparticle Ecotoxicology
      • 1. Introduction to the Earth's Environment
      • 2. Sources of Nanoparticles in the Environment
      • 3. Distribution of Nanoparticles into the Environment
      • 4. Fate of Nanoparticles in the Environment
      • 5. Nanoparticle Ecotoxicology
      • 6. Conclusions
      • 7. Appendices
    • Chapter 9. Human and Environmental Risk Characterization of Nanoparticles
      • 1. Introduction
      • 2. Introduction to Risk Assessment, Risk Management, and Risk Communication
      • 3. Nanoparticle Risk Assessment
      • 4. Governmental Legislations Regarding Nanoparticle Risk
      • 5. Conclusions
      • 6. Appendix: Bulk Particles' Risk Characterization
    • Chapter 10. The Past, Present, and the Future of Nanotechnology
      • 1. Introduction
      • 2. Do the Perceptions of the General Public Regarding Nanotechnology Matter?
      • 3. Does High Toxicity Preclude Nanoparticles from Being Used as Drugs?
      • 4. What Are the Future Applications and Risks of Nanoparticles?
    • Index

Product details

  • No. of pages: 554
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: November 24, 2015
  • Imprint: Academic Press
  • Paperback ISBN: 9780128014066
  • eBook ISBN: 9780128014929

About the Author

Ashok Singh

Associate Professor, Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA

Affiliations and Expertise

Associate Professor, Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA

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