Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases

Vascular Biology and Clinical Syndromes

1st Edition - January 19, 2018

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  • Authors: Protasio Da Luz, Peter Libby, Francisco Laurindo, Antonio Chagas
  • eBook ISBN: 9780128125519
  • Paperback ISBN: 9780128123485

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Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians.

Key Features

  • Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information
  • Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress
  • Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes


Cardiology researchers and cardiologists. Graduate and post-graduate students certainly will also benefit as well as clinicians interested in pathophysiological basis for treatment.

Table of Contents

  • Part I – Basic Features
    Section I – Structure
    1. Vascular Endothelium: a perspective
    2. Development of the coronary system: perspectives for cellular therapy from differentiaton of its precursors
    3. Translational patways in endothelial cell: Implications for angiogenesis
    4. Endothelial barrier: factors that regulate its permeability
    5. Growth factors, endothelial progenitor cells and angiogenesis
    6. Characteristics of Endothelium in both sexes
    Section II – Endocrine functions and metabolic interactions
    7. Hemodynamic forces in the Endothelium: from mechanical transduction to atherosclerosis development
    8. Endothelium dependent vasodilation: NO and other mediators
    9. Endothelial vasoconstrictor substances produced by the endothelium
    10.  Cellular redox pathways in endothelial dysfunction and vascular diseases
    11.  Blood coagulation and Endothelium
    12.  Genetics of Endothelium
    13.  Epigenetic regulation of endothelial function
    14.  Adhesion molecules and the Endothelium
    15. Endothelium and Renin-Angiotensin System

    Part II – Endothelial Dysfunction and Clinical Syndromes
    Section III – Methods of investigation
    16.  Methods for endothelial function investigations in humans
    17.  Endothelial biomarkers
    Section IV – Anging and cognitive function
    18.  Endothelial alterations in aging
    19.  Vascular function in dementia and cognitive decline
    20.  Emotional stress and its influence upon the Endothelium
    Section V - Lipoproteins
    21.  Lipids and lipoprotein mediators of endothelial function and dysfunction
    22.  HDL and Endothelium
    23.  Artificial lipoproteins in endothelial dysfunction and atherosclerosis
    Section VI – Diets and Endothelium
    24.  Influences of diets upon endothelial function
    25.  Effects of mediterranean diet upon endothelial function
    26.  Effects of red wine and polyphenols upon endothelial function and clinical events
    Section VII – Kidney and hypertensive diseases
    27.  Kidney and the Endothelium
    28.  Endothelium and arterial hypertension
    29.  Endothelial alterations in pulmonary hypertension
    Section VIII – Atherosclerosis and Coronary Artery Disease
    30.  Endothelial alterations in chronic coronary disease
    31. Molecular mechanisms of the arterial wall in acute coronary syndromes
    32.  Endothelium: coordenator of acute and chronic inflamation
    33.  Endothelium in atherosclerosis: plaque formation and its complications
    34.  Risk factors and endothelial dysfunctions
    35. Sleep disturbances and endothelial dysfunction
    36. Smoking and Endothelium: Endothelial dysfunction and microcirculation in women with angina and normal coronaries
    Section IX – Heart Failure
    37. Endothelial alterations in heart failure: mechanisms and molecular basis
    38.  Heart Failure: influences of drug intervention upon vessels
    Section X – Percutaneous Coronary Interventions and Cardiac Surgery
    39.  Endothelial repair after percutaneous intervention
    40.  Stents and Endothelium
    41. Vascular disease of the tranplanted heart: physiopathology and therapeutic options
    Section XI – Metabolic Syndromes
    42. Erectyle dysfunction and endothelium
    43.  Obesity, Diabetes and Endothelium: molecular interactions
    Section XII -  Non-Cardiovascular Diseases and Endothelium
    44.  Endothelial mechanisms in pre-eclampsya
    45.  Endothelium and nitric oxide: interactions in câncer evolution
    46. Endothelial function and skin microcirculation
    Section XIII – Treatment Options in Endothelial Dysfunction
    47.  Endothelial dysfunction in the clinical setting: prognosis and therapeutic target
    48.  Physical exercise and the Endothelium
    49. Endothelium and immunologic alterations in atherosclerosis

Product details

  • No. of pages: 758
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: January 19, 2018
  • Imprint: Academic Press
  • eBook ISBN: 9780128125519
  • Paperback ISBN: 9780128123485

About the Authors

Protasio Da Luz

Dr. Da Luz graduated in Medicine from the Federal University of Paraná (1965), PhD in Cardiology at the University of São Paulo (1972) and Post-Graduation at the University of Southern California and Cedar-Sinai Medical Center (UCLA), USA for 5 years. He is currently Member of the Academy of Sciences, Commander of the National Order of Scientific Merit and Senior Professor of Cardiology at the Heart Institute, Faculty of Medicine, University of São Paulo. He was named by his colleagnes one of the most influential cardiologists in Brazil, in the 20th century. He his the recipent of inumerous awards from universities, medical institutins and professional organizations. He received the Jabuti Award in 2004, for the book Endothelium and Cardiovascular Diseases co-edited with Francisco Laurindo and Antonio C.P. Chagas. He is also the author of three additional books regarding medical education and the practice of medicine. In 2015 he received the Fundação Conrado Wessel Award, in Medicine, a most prestigious medical award. The author of over 400 national and internationl publications, including 258 peer-reviewed, and book chapters. Past-President of Sociedade de Cardiologia do Estado de São Paulo (SOCESP), Sociedade Brasileira de Insvestigação Clínica (SBIC), founder and present – President of Associação Brasileira de Cardiologia Translacional (ABCT). He is practing cardiologists and academic researcher as well. His main research areas are atherosclerosis, endothelium and coronary artery disease.

Affiliations and Expertise

Senior Professor of Cardiology, Heart Institute (InCor), School of Medicine, University of São Paulo, Brazil.

Peter Libby

Peter Libby, MD, will assume the role of lead editor on the 12th edition. Dr Libby previously edited the 8th edition. He is Senior Advisor at the Center for Interdisciplinary Cardiovascular Sciences and Mallinckrodt Professor of Medicine at Harvard Medical School. He is also Senior Physician at Brigham and Women's Hospital Harvard Medical School, Boston, MA. He is a world-renowned leader in cardiology

Affiliations and Expertise

Senior Advisor, Center for Interdisciplinary Cardiovascular Sciences, Mallinckrodt Professor of Medicine, Harvard Medical School, Senior Physician, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts

Francisco Laurindo

Dr. Laurindo is a Member of the Evaluation of Graduate Programs Strict Sense Committee on Higher Education Personnel Improvement Coordination - CAPES and Chairperson of the Ad Hoc Scientific Committee of InCor - HCFMUSP. He participates as a reviewer or member of editorial board of journals including the Journal of Invasive Cardiology, Free Radical Biology & Medicine, Brazilian Journal of Medical and Biological Research, Arteriosclerosis, Thrombosis, and Vascular Biology, The FASEB Journal, Antioxidants & Redox Signaling, and the American Journal of Physiology; among others. He is also a Member of the Federation Advisory Council of Societies for Experimental Biology (FeSBE) and and the Brazilian Society of Clinical Investigation. His research line is in molecular biology atherosclerotic vascular disease with an emphasis on cardiology, acting on the following subjects: vascular, oxidative stress, atherosclerosis, NADPH oxidase and angioplasty.

Affiliations and Expertise

Department of Health (São Paulo - State). Hospital das Clinicas, Faculty of Medicine, USP (FMUSP). Heart Institute Teacher Euryclides Jesus Zerbini (INCOR)

Antonio Chagas

Graduated in Medicine at the Faculty of Medicine of ABC (1977), PhD (1992) and Free-Teaching (1996) from the Faculty of Medicine, University of São Paulo. In 2012 he was approved in the Public Tender for Professor at the Faculty of Medicine of ABC. Held Graduate in the United States at the Cardiovascular Research Institute, University of California, San Francisco, USA. He is currently Professor and Head of the Discipline of Cardiology, ABC School of Medicine exercising teaching, research and assistance in the areas of undergraduate and postgraduate. He is an active researcher in translational medicine, acting on the following topics: atherosclerosis, myocardial infarction, coronary artery disease, cardiac mechanics and congestive heart failure. He chaired the Cardiology Society of the State of São Paulo (2001-2003) and the Brazilian Society of Cardiology (2008-2009), was the first Governor of the Brazilian Chapter of the American College of Cardiology (2008-2013) and Member of the International Council of American College of Cardiology and the Presidential Task force and Editorial Consultant of the Journal of the American College of Cardiology. Fellow of the American College of Cardiology and the European Society of Cardiology, is Founding Member of Cardiology Lusophone Federation.

Affiliations and Expertise

Faculty of Medicine of ABC , Santo André; Internal Medicine ( General Medicine ), Cardiothoracic Surgery; Brazilian Society of Cardiology (SBC)

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