Endocytosis and Exocytosis, Volume 4

1st Edition

Editors: A.G. Lee
Hardcover ISBN: 9781559386616
eBook ISBN: 9780080530888
Imprint: Elsevier Science
Published Date: 1st December 1996
Page Count: 294
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Table of Contents

Contents. List of Contributors. Preface (A.G. Lee). Receptor-Mediated Endocytosis (A.P. jackson, H.D. Blackbourn, S.F.C. Hawkins, and M.J.G. Hughes). Phagocytosis (E.J. Brown and T.H. Steinberg). Annexin Hypothesis for Exocytosis (A.L. Burns and H.B. Pollard). Small Synaptic Vesicles (N.V.L. Hayes and A.J. Baines). Membrane Attack by Complement: Assembly and Biology of Terminal Complement Complexes (M.L. Shin, H.G. Rus, and F.I. Niculescu). Cell Membrane Damage in Lymphocyte-Mediated Cytolysis: Role of Lymphocyte Pore-Forming Protein Perforin (C. Liu, P.M. Persechini, M.F. Horta, and J.D.E. Young). The Asialoglycoprotein Receptor (C. Fuhrer and M. Spiess). The Low Density Lipoprotein Receptor (A. Ozinsky, G.A. Coetzee, and D.R. van der Westhuyzen). Mannose-6-Phophate Receptors (R. Pohlmann). The Transferrin Receptor (C.A. Enns, E.A. Rutledge, and A.M. Williams). Index.

Description

Volume 4 of Biomembranes covers endocytosis, exocytosis and related processes. A major role of the plasma membrane is as a permeability barrier, keeping the inside of the cell inside and the outside, outside. Mechanisms must then exist to allow movement of material between the cell and its environment. One mechanism for export from the cell is by exocytosis, a process in which the membranes of secretory vesicles fuse with the plasma membrane releasing the contents of the vesicle into the extracellular medium. The process has been studied in particular depth for the release of neurotransmitters at the synapse. Import into the cell is possible by the process of receptor-mediated endocytosis in which selected plasma membrane proteins are internalizes; when these proteins are receptors for macromolecules, the result is uptake of the macromolecule. Transferring, the low-density lipoprotein, and asialoglycoproteins are all taken up into cells in this way. Phagocytosis, the ingestion of cells and cell fragments by neutrophils and macrophages, also involves receptors - on the phagocytic membrane - of which the best studied are those for the Fc domain of IgG, for the third component of complement, and for the mannose/fructose carbohydrates. Protection of a host against infection can also be achieved by damaging the integrity of the plasma membrane of the invading organism. This is the strategy evolved by the cytotoxic T lymphocytes, which produce a pore-forming toxin, perforin. Volume 4 of Biomembranes explores the structures and mechanisms involved in these biologically and medically important processes.


Details

No. of pages:
294
Language:
English
Copyright:
© Elsevier Science 1996
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080530888
Hardcover ISBN:
9781559386616

Reviews

Volume 4 of Biomembranes covers endocytosis, exocytosis and related processes. A major role of the plasma membrane is as a permeability barrier, keeping the inside of the cell inside and the outside, outside. Mechanisms must then exist to allow movement of material between the cell and its environment. One mechanism for export from the cell is by exocytosis, a process in which the membranes of secretory vesicles fuse with the plasma membrane releasing the contents of the vesicle into the extracellular medium. The process has been studied in particular depth for the release of neurotransmitters at the synapse. Import into the cell is possible by the process of receptor-mediated endocytosis in which selected plasma membrane proteins are internalizes; when these proteins are receptors for macromolecules, the result is uptake of the macromolecule. Transferring, the low-density lipoprotein, and asialoglycoproteins are all taken up into cells in this way. Phagocytosis, the ingestion of cells and cell fragments by neutrophils and macrophages, also involves receptors - on the phagocytic membrane - of which the best studied are those for the Fc domain of IgG, for the third component of complement, and for the mannose/fructose carbohydrates. Protection of a host against infection can also be achieved by damaging the integrity of the plasma membrane of the invading organism. This is the strategy evolved by the cytotoxic T lymphocytes, which produce a pore-forming toxin, perforin. Volume 4 of Biomembranes explores the structures and mechanisms involved in these biologically and medically important processes.


About the Editors

A.G. Lee Editor

Affiliations and Expertise

Department of Biochemistry, University of Southampton, Southampton, England