Human biological liquids contain numerous low- and high-molecular weight surfactants. The human organism contains interfaces with enormous surfaces. The physicochemical and biochemical processes taking place at these interfaces are extremely important for the vital functions of the organism as a whole, and the interfacial properties may reflect peculiarities of age and sex, health and disease. The present book is the first attempt to systematically present the results of dynamic and equilibrium surface tensions measurements of serum and urine samples that were obtained from healthy humans of various sex and age, and to compare these results with measurements of biological liquids obtained from patients suffering from various diseases or with measurements of amniotic fluid obtained from women at various stages of pregnancy.
Pulmonary medicine, especially neonatology, has systematically used interfacial tensiometry for studying pulmonary surfactant. In this particular area, significant progress was achieved in the treatment of diseases related to alterations of the lung surfactant system. We believe that, similar to the progress in pulmonary medicine attributed to surface chemical studies of lung surfactant, progress in other medical branches could be expected through studies of interfacial characteristics of other human biological liquids.
For several years the authors of this book have been engaged in studies aimed at the improvement of the maximum bubble pressure method, resulting in the development of computer controlled tensiometers which are capable of measuring dynamic surface tensions within a wide range of surface lifetime. In addition to the measurement techniques, a correct interpretation and analysis of the tensiometric data obtained is extremely important. The kinetic theory of adsorption from solutions, and the theory of equilibrium adsorption layers of surfactant/protein mixtures provide the basis for both the choice of the

Table of Contents

Theory of Protein Adsorption and Model Experiments. Thermodynamics of protein adsorption at the liquid/fluid interfaces. Adsorption kinetics. Experimental studies of model biological liquids. Influence of additives. Summary. References. Experimental Technique and Analysis of Tensiograms. Experimental methods. The design of maximum bubble pressure tensiometer. Theory of the maximum bubble pressure method. Experimental technique. Analysis of tensiograms. Summary. References. Dynamic Interfacial Tensiometry of Biological Liquids for Healthy Persons. Dependence of dynamic surface tension on sex and age of patients. Dynamic surface tension of serum and amniotic liquid for pregnant women. Summary. References. Application of Surface Tensiometry in Nephrology. Glomerulonephrites. Variation in surface tensiometric parameters for various forms of the disease. Influence of particular serum and urine components on dynamic surface tension. Effect of treatment on variations in surface tensiometric parameters. Primary pyelonephritis and urolithiasis. Diabetic nephropathy. Other renal diseases. Summary. References. Surface Tensiometry in Rheumatology. Pathogenesis of rheumatic diseases. Systemic lupus erythematosus. Rheumatism. Sclerodermia systematica. Rheumatoid arthritis. Reiter's disease. Psoriasis. Gout. Osteoarthrosis. Effect of glucocorticoid therapy and plasmapheresis. Summary. References. Surface Tensiometry in Pulmonology. Pathogenesis of respiratory diseases. Bronchitis. Bronchial asthma and other pulmonary diseases. Dust pathology of respiratory organs. Summary. References. Surface Tensiometry in Neurology. Tensiogram parameters for diseases of the nervous system. Influence of the nosological form of an infection dise


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© 2000
Elsevier Science
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About the editors

O.V. Sinyachenko

Affiliations and Expertise

Medical University Donetsk, Ukraine

V.B. Fainerman

Affiliations and Expertise

Institute of Technical Ecology, Donetsk, Ukraine

U. Pison

Affiliations and Expertise

Virchow Klinik, Charité, Humboldt Universität, Berlin, Germany

R. Miller

Affiliations and Expertise

Max-Planck Institut für Kolloid und Grenzflächenforshung, Am Mühlenberg 1, 14476 Golm, Germany