Diffusion MRI of the Breast

1st Edition - June 18, 2022
Editors: Mami Iima, Savannah Partridge, Denis Le Bihan
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 7 9 7 0 2 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 1 1 0 2 - 6

Diffusion weighted imaging (DWI) is a key emerging imaging modality for the management of patients with possible breast lesions, and Diffusion MRI of the Breast is the first book… Read more

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Diffusion weighted imaging (DWI) is a key emerging imaging modality for the management of patients with possible breast lesions, and Diffusion MRI of the Breast is the first book to focus on all aspects of DWI in today’s practice. It covers the knowledge necessary to undertake clinical breast DWI, with a thorough review of how DWI is currently used as a breast imaging modality and how breast lesions appear on DWI. Expert clinicians and physicists from around the world share their knowledge and expertise on everything from technical requirements and image analysis to clinical applications of DWI (diagnosis, prognosis, treatment monitoring) with case examples, and upcoming developments in the field (radiomics, AI).

Cover image
Title page
Table of Contents
Any screen, Any time, Anywhere
Copyright
List of Contributors
Foreword
Chapter 1. General Principles and Challenges of Diffusion MRI
Abstract
Basic Diffusion MRI, Diffusion-Weighted Imaging (DWI), and the Classic Apparent Diffusion Coefficient (ADC)
Pitfalls, Challenges, and Common Issues Found in Clinical Practice
Conclusion
References
Chapter 2. Conventional Breast Imaging
Abstract
Imaging Techniques and Image-Guided Biopsy
Using Conventional Breast Imaging in Clinical Practice
DWI of the Breast
References
Chapter 3. Overview of Breast DWI: Diagnosis of Suspicious Lesions Using DWI in Combination With Standard MRI
Abstract
The Need for Reducing Unnecessary Biopsies in Breast MRI
DWI and the ADC in Clinical Practice
Analysis of DWI Images
Considerations for Implementing ADC Measurements in Clinical Practice
Future Considerations
References
Chapter 4. Biomarkers, Prognosis, and Prediction Factors
Abstract
Background
Classification of Breast Cancer
Diffusion-Weighted Imaging Predicting Markers of Tumor Aggressiveness
Diffusion-Weighted Imaging for Tumor Staging and Surgical Planning
Future Directions
Conclusions
References
Chapter 5. Disease and Treatment Monitoring
Abstract
Diffusion-Weighted Magnetic Resonance Imaging Approaches for Treatment Monitoring
Tumor Mean ADC for Predicting Response
Alternative DWI Metrics to Mean ADC
Combined DCE and DWI Approaches to Outcome Prediction
Subtype Dependency of ADC Prediction
Current Challenges and Future Directions
References
Chapter 6. Diffusion MRI as a Stand-Alone Unenhanced Approach for Breast Imaging and Screening
Abstract
List of Abbreviations
Current Evidence for DW MRI as a Stand-Alone Modality
Technical Requirements as an Unenhanced Screening Modality
Image Interpretation Strategies
Target Population for Unenhanced MRI Screening
Other Issues in Clinical Implementation
Ongoing Prospective Trials
Summary
References
Chapter 7. DWI and Breast Physiology Status
Abstract
Menstrual Cycle
Pregnancy and Lactation
Involution
Pregnancy-Associated Breast Cancer
Menopause
Summary and Outlook
References
Chapter 8. IVIM and Non-Gaussian DWI of the Breast
Abstract
Intravoxel Incoherent Motion and Non-Gaussian Diffusion-Weighted Imaging: Introduction
Clinical Application of IVIM and Non-Gaussian DWI
Image Acquisition Schemes for Breast DWI
Data Analysis of IVIM and Non-Gaussian DWI
Balancing Biophysical Complexity and Practical Clinical Benefit
References
Chapter 9. Diffusion Tensor Imaging (DTI) of the Breast
Abstract
DTI in the Breast: Basics, Metrics, and Pitfalls
Fibroglandular Tissue (FGT) DTI
Clinical Application of Breast DTI
Breast DTI: Advances and Extensions
Overview/Outlook
References
Chapter 10. Artificial Intelligence—Enhanced Breast MRI and DWI: Current Status and Future Applications
Abstract
Background
Basic Concepts of Radiomics and AI Methodology
AI-Enhanced Breast MRI
Use Cases
Challenges and Future Perspectives
Conclusion
References
Chapter 11. Diffusion-Weighted Whole Body Imaging With Background Body Signal Suppression (DWIBS)
Abstract
Basic Concept of Diffusion-Weighted Whole Body Imaging With Background Body Signal Suppression (DWIBS)
The Importance of Fat Suppression in DWIBS
Application to Breast Cancer Screening
Limitations of DWIBS
References
Chapter 12. High-Resolution Diffusion-Weighted Breast MRI Acquisition
Abstract
Standard Echo-Planar Diffusion-Weighted Imaging
Fat-Suppression Methods
Reducing Distortion, Blurring, and Scan Times With Available Methods
Other Advanced Methods
Summary
References
Chapter 13. Clinical Interpretation of Diffusion MRI, ROI Assessment, Common Errors, Pitfalls and Artifacts, Challenges in Acquisition
Abstract
Clinical Interpretation
REGION OF INTEREST (ROI) ASSESSMENT
Common Errors, Pitfalls, Artifacts
Challenges in Acquisition
References
Chapter 14. Multiplatform Standardization of Breast DWI Protocols: Quality Control and Test Objects
Abstract
Overview of Breast Diffusion-Weighted Imaging Standardization Efforts
Optimization and Standardization of Breast DWI Acquisition and Analysis
Test Objects and Quality Control for Breast DWI
Conclusion
References
Chapter 15. Routine and Advanced Breast DWI Techniques and Processing: The Siemens Healthineers Per spective
Abstract
Data Acquisition
Data Processing and Management
Works in Progress
References
Chapter 16. Breast Diffusion MRI Acquisition and Processing Techniques: The GE Healthcare Perspective
Abstract
Data Acquisition
Data Processing and Reconstruction
References
Chapter 17. Breast DWI Techniques and Processing: The Philips Perspective
Abstract
Data Acquisition
Essential Elements of Postprocessing
Future Aspects
References
Chapter 18. Diffusion-Weighted Imaging (DWI) for Breast Lesion Characterization: The Olea Medical Perspective and the Utilization of Olea Sphere Software
Abstract
The Importance of Postprocessing and Data Analysis for Breast Diffusion Weighted Imaging
Breast Diffusion Image Pre- and Postprocessing in Olea Sphere
Future Directions
Acknowledgments
References
Index
Confidence is ClinicalKey

Mami Iima

Mami Iima, M.D., Ph.D. is an Assistant Professor in the Department of Diagnostic Imaging and Nuclear Medicine at Kyoto University Graduate School of Medicine, and the Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital, Japan. Dr. Iima is a breast radiologist who has received many awards and published important articles about diffusion and IVIM MRI in the breast, and a comprehensive breast DWI review. She is an active committee member in Radiological Society of North America (RSNA) and International Society for Magnetic Resonance in Medicine (ISMRM).

Savannah Partridge

Savannah C. Partridge, Ph.D. is a Professor in the Departments of Radiology and Bioengineering, and the Research Director for Breast Imaging at the University of Washington School of Medicine. She is also the Associate Director of Cancer Imaging at the Seattle Cancer Care Alliance in Seattle, Washington, USA. Dr. Partridge is a leading expert in technique optimization and clinical validation of diffusion MRI of the breast. She is an active member in multiple international cancer and imaging cooperative groups and has led two large multi-institutional breast DWI clinical trials through the Eastern Cooperative Oncology Group – American College of Radiology Imaging Network (ECOG-ACRIN).

Affiliations and expertise

Professor, Department of Radiology, University of Washington, Seattle, WA, USA

Denis Le Bihan

Denis Le Bihan, MD, PhD, is the Founding Director of NeuroSpin in Saclay, France. He's a Member of the Institute of France, Visiting Professor of Kyoto University Graduate School of Medicine, at Kyoto Prefectural University of Medicine and the Japan National Institute of Physical Sciences, Okazaki, Japan. Dr. Le Bihan, a radiologist and physicist, pioneered diffusion MRI and the IVIM method in the 1980s, for which he has received many important awards. His is a member of the French Academy of Sciences, Academy of Technologies, Academy of Pharmacy and the Academy of Medicine. With Julia Camps-Herrero he co-founded the “Breast DWI Club” of the European Society of Breast Imaging (EUSOBI).