Cyclitols and Phosphoinositides

Cyclitols and Phosphoinositides

1st Edition - January 1, 1978

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  • Editor: William W. Wells
  • eBook ISBN: 9780323144315

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Cyclitols and Phosphoinositides covers the proceedings of the 1977 Conference on Cyclitols and Phosphoinositides, held at the Kellogg Center for Continuing Education, Michigan State University, East Lansing, Michigan. This book is organized into eight parts encompassing 43 chapters. The first parts describe the chemistry of cyclitols, inositol phosphates, and phosphoinositides. The subsequent parts explore the ubiquitous myoinositol and its phospholipids in animals, plants, yeast, bacteria, and molds; in various body parts, such as iris, brain, nerves, pineal, testis, lymphocytes, pancreas, parotid, retina, synapses, lysosomes; and the test tube. The last parts consider the mechanism of inositol biosynthesis and the meaning of increased phosphatidylinositol turnover in response to extracellular stimuli. This book will prove useful to research workers in the fields of organic chemistry, biochemistry, genetics, physiology, microbiology, pharmacology, botany, and nutrition.

Table of Contents

  • List of Contributors


    Part I: Chemistry of the Cyclitols

    Artificial Lipids Containing Cyclopentanoid Backbones

    Intramolecular Aldol Condensations of Delta-Dicarbonyl Sugars—A Novel

    Approach to the Syntheses of Cycloses

    The Isolation and Identification of Inositol Phosphate Intermediates by Ion Exchange Chromatography

    Chemistry and Physiology of myo-Inositol Esters of I ndole-3-Acetic Acid

    Part II: Inositol Phosphates and Phosphoinositides

    A Novel Metabolic Cycle Involving /wyo-Inositol Phosphates during Formation and Germination of Seeds

    Phosphoinositol Kinase from Plant and Avian Sources

    Phosphoinositides of Fungi and Plants

    Part III: Phosphoinositides I

    The Acetylcholine Phospholipid Effect: What Has It Told Us? What Is It Trying to Tell Us?

    Studies on the Role of Triphosphoinositide in Cholinergic Muscarinic and α-Adrenergic Receptors Function of Iris Smooth Muscle

    Phosphatidylinositol, Triphosphoinositide, and Synaptic Transmission

    Interaction of Aminocyclitol Antibiotics with Polyphosphoinositides in Mammalian Tissues and Artificial Membranes

    Nature of the Receptors which Mediate Enhanced Phosphatidylinositol Turnover in Rat Pineal Gland

    Modification of Phosphatidylinositol Metabolism by Propranolol and Local Anesthetics

    Phosphatidylinositol Metabolism in Rat Brain Preparations

    Selectivity in Pathways of Cytidine Diphosphate Diacylglycerol Formation

    Effects of Cyclic Nucleotides and Related Agents on Renal Polyphosphoinositicje Metabolism

    Part IV: Biosynthesis of Inositol

    Some Enzymes of Inositol Metabolism, Their Purification and Their Mechanism of Action

    Aspects of myo-Inositol Metabolism and Biosynthesis in Higher Plants

    Intermediates in the wyo-Inositol 1-Phosphate Synthase Reaction

    Studies on Enzymes of Inositol Metabolism

    Further Characterization of the myo-Inositol 1-Phosphate Synthase from Neurospora crassa

    Inositol-1-Phosphate Synthase Mutants of the Yeast, Saccharomyces cerevisiae

    The Distribution of Radioactive myo-Inositol in the Reproductive Tract of the Male Rat. The Blood-Testis Barrier to myo-Inositol

    Part V: Phosphoinositides II

    The Influence of Intracellular Ca2+ on the Metabolism of Inositol Phospholipids in Lymphocytes and Erythrocytes

    Phosphatidylinositol Hydrolysis and Insulin Secretion from the Rat Pancreatic Islet

    The Mechanism of Stimulated Phosphatidylinositol Breakdown

    Colchicine Enhances myo-Inositol Stimulation of Secretion by Rat Pancreatic Tissue in Vitro

    Hormonal Effects on myo-Inositol Metabolism in the Dog

    Phosphatidylinositol Kinase and Diphosphoinositide Kinase in the Rat Parotid Gland

    Studies of Phosphatidylinositol Phosphodiesterase

    Part VI: Function I

    Biosynthesis of Aminocyclitols and Guanidinocyclitols

    The Role of Inositol Glucosides in the Synthesis of 01, 3-Glucans

    Abnormal Lipid Metabolism due to myo-Inositol Deficiency in Rats and Yeast

    Requirement for Dietary myo-Inositol in the Lactating Rat

    Part VII: Function II

    Active Transport of Cyclitols in Bacteria

    Cyclohexitol Transport in the Central Nervous System

    Lithium and Brain myo-Inositol Metabolism

    Part VIII: Phosphoinositides III

    Studies on the Metabolic Heterogeneity of Different Molecular Species of Phosphatidylinositols

    Phosphoinositide Metabolism in Peripheral Axons

    The Arachidonoyl Groups of Phosphatidylinositols in Brain Synaptosomes

    Metabolism of Phosphatidylinositol in the Retina

    Tissue Culture Studies on the Metabolism of myo-Inositol

    Acidic PhosphoUpids and Lysosomal Bis (Monoacylglyceryl) Phosphate Synthesis: The Role of Phosphatidylinositol and Lysophosphatidylglycerol

    Concluding Remarks


Product details

  • No. of pages: 624
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323144315

About the Editor

William W. Wells

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