Concepts of Membrane Structure

Concepts of Membrane Structure

1st Edition - December 28, 1982

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  • Editor: Ronald Aloia
  • eBook ISBN: 9780323155212

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Membrane Fluidity in Biology, Volume 1: Concepts of Membrane Structure covers membrane properties influenced by alterations in membrane lipid compositions and/or other organizational parameters that are encompassed by the term fluidity. This book is composed of eight chapters that discuss significance of fluidity changes in both normal and pathological cellular functions. This book starts by describing membrane structural organization and composition and arrangement of the molecular components of cell membranes. This is followed by discussions on structural properties of lipids and role of nonbilayer lipid structures in membrane fusion. The methodological approaches in study of cellular membrane structural diversity and fluid mosaic model for accurate representation of membrane fluidity are also discussed. This volume then describes the phenomenon of reversed or ""negative"" membrane images, as viewed with transmission electron microscope. Chapters 6 and 7 explain the interaction of cytochrome P-450 with phospholipids and proteins in the endoplasmic reticulum and steps in the derivation of membrane structure and packing principles. Finally, the concluding chapter focuses on the membrane of the human red blood cell and presents relatively simple arguments concerning its physical properties. The book will serve as a primary source for research scientists and teachers interested in cellular membrane fluidity phenomena.

Table of Contents

  • Contributors


    1. Nonrandom Lateral Organization in Bilayers and Biomembranes


    Domains of One Phase in Single Component Bilayers

    Coexistence of Solid and Liquid Phases at the Main Transition

    Domains of Monotectic and Eutectic Phases in Multicomponent Bilayers

    Induction of Isothermal Phase Change

    Lateral Organization in Biomembranes

    Patching and Capping of Cell Surface Receptors in Response to Ligand Binding



    2. Structural Properties of Lipids and Their Functional Roles in Biological Membranes


    Structural Preferences of Membrane Lipids

    Isothermal Modulation of Membrane Lipid Structure

    Potential Roles of Nonbilayer Lipid Structure in Membranes

    A Rationale for Lipid Diversity—The Shape Concept

    Closing Remarks


    3. Diversity in the Observed Structure of Cellular Membranes


    The Approach and the Methods

    The Crista Membrane in Mitochondria

    Surface Membranes in Mitochondria

    Mitochondrial Membranes: Conclusions

    Outer Segment Disks in Photoreceptor Cells

    Plasma Membrane of the Outer Segment

    Outer Segment of Photoreceptor Cells: Conclusions


    4. Correlation of Membrane Models with Transmission Electron Microscopic Images

    Introduction: The Unit Membrane Model and the Unit Membrane Image

    Problems of Adequate Fixation for Erythrocyte Ghosts

    Fixation in Other Membrane Systems

    New Techniques


    5. Negative Images and the Interpretation of Membrane Structure


    Preparative Procedures Which Result in a Negative Membrane Image

    Negative Images in Chloroplast Granal Membranes



    6. Interactions of Cytochrome P-450 with Phospholipids and Proteins in the Endoplasmic Reticulum

    Protein-Lipid Interactions of Intrinsic Membrane Proteins

    Lipid-Protein Interactions of Cytochrome P-450 in Reconstituted



    7. Membrane Composition, Structure, and Function


    Steps in the Derivation of Membrane Structure and Packing Principles

    Graphic Analysis and Membrane Structure

    Packing of Cholesterol, Gangliosides, and Ceramide Polyhexosides in Membranes


    8. Mechanoelastic Properties of Biological Membranes


    Special Problems of Biconcave Membranes

    Calculation of Elastic Strain Energy




Product details

  • No. of pages: 340
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: December 28, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323155212

About the Editor

Ronald Aloia

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