Computational Epigenetics and Diseases

Computational Epigenetics and Diseases

1st Edition - February 6, 2019

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  • Editor: Loo Wei
  • eBook ISBN: 9780128145142
  • Hardcover ISBN: 9780128145135

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Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research.

Key Features

  • Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases
  • Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA
  • Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases


Graduate students on bioinformatics and genetics, bioinformaticians, healthcare professionals, pharmacologists, physicians

Table of Contents

  • 1. Computational Epigenetics and Disease
    2. Computational Methods for Epigenomics Analysis
    3. Statistical Approaches for Epigenetic Data Analysis
    4. Bioinformatics Methodology Development for the Whole Genome Bisulfite Sequencing
    5. Data Analysis of ChIP-Seq Experiments: Common Practice and Recent Developments
    6. Computational Tools for MicroRNA Target Prediction
    7. Integrative Analysis of Epigenomics Data
    8. Differential DNA Methylation and Network Analysis in Schizophrenia
    9. Epigenome-Wide DNA Methylation and Histone Modification Profiling in Alzheimer's Disease
    10. Epigenomic Reprogramming in Cardiovascular Diseases
    11. Bioinformatic and Biostatistic Methods for DNA Methylome Analysis of Obesity
    12. Epigenomics of Diabetes Mellitus (Epigenetic Regulations in Diabetes Mellitus)
    13. Epigenetic Profiling in Head and Neck Cancer
    14. Epigenome-Wide DNA Methylation Profiles in Oral Cancer
    15. Computational Epigenetics for Breast Cancer
    16. Integrative Epigenomics of Prostate Cancer
    17. Network Analysis of Epigenetics Data for Bladder Cancer
    18. Epigenome-Wide Analysis of DNA Methylation in Colorectal Cancer
    19. Integrative OMIC Analysis of Neuroblastoma
    20. Computational Analysis of Epigenetic Modifications in Melanoma
    21. DNA Methylome of Endometrial Cancer
    22. Epigenetics and Epigenomics Analysis for Autoimmune Diseases
    23. Computational Epigenetics in Lung Cancer

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: February 6, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128145142
  • Hardcover ISBN: 9780128145135

About the Series Volume Editor

Loo Wei

Loo Keat Wei is Doctor of Philosophy on Human Genetics by Universiti Sains Maysia. Dr. Loo is a young scientist in Malaysia, who has showed a great interest and curiosity in the field of computational epigenetics. She has published several articles in this emerging field and has been awarded many prestigious international and national research grants such as Australia Endeavour Award, Ministry of Higher Education Fundamental Research Grant Scheme, Research Publication Schemes, Universiti Tunku Abdul Rahman Research Funds, etc., successfully securing more than USD $200,000 funds in the last three years. She is the member of International Stroke Genetics Consortium, Reviewer and Editorial Board Member in multiple journals.

Affiliations and Expertise

Assistant Professor, Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Malaysia

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