Cell Sources for iPSCs

Cell Sources for iPSCs

1st Edition - May 9, 2021

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  • Editor: Alexander Birbrair
  • Paperback ISBN: 9780128221358
  • eBook ISBN: 9780128223277

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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. Cell Sources for iPSCs, Volume 7 teaches readers about current advances in the field. It shares up-to-date comprehensive overviews of current advances in the field. This book describes the derivation of iPSCs from different sources in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. The authors focus on the modern state-of-art methodologies and the leading-edge concepts in the field of stem cell biology. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. Thus, this book is an attempt to describe the most recent developments in iPSCs biology, which is one of the rising hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on how we derive iPSCs from distinct sources. Ten chapters written by experts in the field summarize the present knowledge about different cell sources for iPSCs. This volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

Key Features

  • Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics
  • Covers the following: myoblast-derived iPSCs, lymphoblastoid-derived iPSCs, amniotic fluid stem cell–derived iPSCs, spermatogonial stem cell–derived iPSCs, iPSCs derived from postmortem tissue, and more
  • Contributed by world-renowned experts in the field


Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields

Table of Contents

  • 1. Induced Pluripotent Stem Cells Derived from Amniotic Fluid Stem Cells
    2. Induced Pluripotent Stem Cells from Spermatogonial Stem Cells: Potential Applications
    3. Induced Pluripotent Stem Cell Derivation from Myoblasts
    4. Lymphoblastoid-Derived Human-induced Pluripotent Stem Cells: A New Tool to Model Human Diseases
    5. Oral Tissues as Sources for Pluripotent Stem Cell Derivation and their Applications for Neural, Craniofacial, and Dental Tissue Regeneration
    6. Induced Pluripotent Stem Cell Derived from Ovarian Tissue
    7. Muse Cells as a Robust Source of Induced Pluripotent Stem Cells
    8. Prostate Cancer Reprogramming and Dedifferentiation into Induced Pluripotent Stem Cells
    9. Melanoma-Derived Induced Pluripotent Stem Cells: A Model for Understanding Melanoma Cell of Origin and Drug Resistance
    10. Induced Pluripotent Stem Cell Derived from Postmortem Tissue in Neurodegenerative Disease Research

Product details

  • No. of pages: 280
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: May 9, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128221358
  • eBook ISBN: 9780128223277

About the Editor

Alexander Birbrair

Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA), and in 2021, he was elected affiliate member of The World Academy of Sciences (TWAS). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Affiliations and Expertise

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Department of Radiology, Columbia University Medical Center, Medical Center, USA

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