Biology of Mycobacterial Lipids

Biology of Mycobacterial Lipids

1st Edition - June 3, 2022

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  • Editors: Zeeshan Fatima, Stéphane Canaan
  • Paperback ISBN: 9780323919487
  • eBook ISBN: 9780323919449

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Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome.

Key Features

  • Covers major biochemical aspects of mycobacterial lipids, nomenclature, structure and classification, and metabolic pathways
  • Focuses on recent trends and state-of-the-art technology, used in mycobacterial lipids study
  • Brings together the functional aspects of mycobacterial lipidome, involvement of lipids in cellular network and signaling, its involvement in virulence and resistance, and host factor manipulations
  • Highlights the discovery of lipid biomarkers, for diagnostic and therapeutic interventions, using mycobacterial lipidomic studies
  • Presents lipids at the interface of various other biomolecules with integrative omics aspects


Biomedical scientists, researchers, and those in healthcare industries, involved in various aspects of mycobacterial diseases; Students of biomedicine, pathology, and pharmacy

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Tribute for Professor David E. Minnikin, MA, DPhil, DSc (1939–2021)
  • List of contributors
  • Foreword
  • Preface
  • Chapter 1. An overview of mycolic acids: structure–function–classification, biosynthesis, and beyond
  • Introduction
  • What are lipids?
  • Lipid profile of Mycobacterium
  • What are MAs?
  • Structure of MAs
  • Tools and techniques to study mycobacterial lipids
  • Tools for lipid analysis
  • MTB lipidomics at the interface of the other omics technologies
  • Chapter 2. Lipid biosynthetic pathways as potential drug targets for emerging mycobacterial pathogens
  • Introduction
  • Subsystems in Mtb versus NTMs
  • Lipids in mycobacterial cell wall
  • Review of drug target space in mycobacterial lipid pathways
  • Unique lipids in NTMs
  • Inhibitors of mycobacterial lipid pathways
  • The roadmap
  • Chapter 3. Mycobacterial lipids in the host–pathogen interface: roles in pathogenesis and host immune response
  • Introduction
  • Mycobacterium cell envelope architecture and composition: a brief overview
  • M. tuberculosis cell wall lipids and its roles in pathogenesis and host immune response
  • Innate immune recognition of mycobacterial lipids: pattern recognition receptors
  • Recognition of lipid by T cells (TCR): an adaptive response
  • Outlook and conclusion
  • Chapter 4. Lipids and glycolipids as biomarkers of mycobacterial infections
  • Early stage development of lipid biomarkers
  • Mycolic acids as biomarkers for mycobacterial diagnosis
  • Using lipoarabinomannan as a lipid biomarker for TB diagnosis
  • Other lipids as biomarkers for mycobacterial diagnosis
  • Lipid biomarkers and drug susceptibility
  • Conclusions
  • Chapter 5. Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions
  • Introduction
  • Mycobacterial cell membrane envelope
  • Mycobacterial free lipids: what are they and how they reach the host cell during infection
  • Mtb free lipids and manipulation of the host immune system
  • Host membrane insertion and alteration of membrane biophysical properties by Mtb free lipids: previously unknown mode of action of virulent lipids
  • Actin restructuring by Mtb free lipids: involvement of host cytoskeleton and actin-binding host partners
  • Conclusion
  • Chapter 6. Conserved mechanisms drive host-lipid access, import, and utilization in Mycobacterium tuberculosis and M. marinum
  • Introduction
  • Conservation of the access to host lipids between M. tuberculosis and M. marinum
  • Host-derived lipid import systems in mycobacteria
  • Conservation of host-derived lipid utilization pathways in M. marinum
  • Summary and perspectives
  • Chapter 7. Biological implications of mycobacterial lipids on NKT-cells stimulation
  • Introduction
  • Types of NKT cells
  • Role of NKT cells in the control of TB infection
  • Concluding remarks and future perspective
  • Chapter 8. The effect of chemically synthetic mycobacterial mycolates on phospholipidome immunomodulation of murine macrophages
  • Introduction
  • Materials and methods
  • Results
  • Discussion
  • Chapter 9. Polyketide synthases in mycobacterial lipid metabolism
  • Introduction
  • Mycobacterial cell wall: A treasure trove of exotic lipids
  • FAAL proteins facilitate cross-talks between FASs and PKs
  • Type III polyketide synthases
  • Fatty acid degradation pathway in mycobacteria
  • Conclusion
  • Chapter 10. Understanding mycobacterial lipid metabolism and employing it as a tool to produce attenuated TB vaccine candidates
  • The role of M. tuberculosis lipids in TB pathogenesis
  • OMICs approaches and their impact in understanding M. tuberculosis pathogenesis
  • Development of vaccine candidates based on modification of M. tuberculosis genes involved in lipid metabolism
  • Concluding remarks about vaccine development
  • Chapter 11. Deciphering the physiological role of serine enzymes involved in mycobacterial lipid metabolism using activity-based protein profiling
  • Introduction
  • Serine enzymes in M. tb—the fundamental of a new drug family development
  • Activity-based protein profiling, a powerful versatile chemical proteomic platform applied to characterize the functional state of serine enzymes in mycobacteria
  • Conclusion and prospects
  • Chapter 12. Intrabacterial lipid inclusions: overview of an amazing organelle
  • Introduction
  • Discovery
  • Occurrence and inheritance: a conserved structure
  • ILI-associated protein partners
  • Proximity labeling technologies: strengths and limitations
  • Perspectives and concluding remarks
  • Chapter 13. Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans
  • Buruli ulcer, Mycobacterium ulcerans and mycolactone: general considerations
  • Historical background for the discovery of mycolactone
  • Mycolactone: chemical nature and synthesis
  • Biological activities of mycolactone
  • Mycolactone as a diagnostic target?
  • Conclusion
  • Index

Product details

  • No. of pages: 314
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: June 3, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323919487
  • eBook ISBN: 9780323919449

About the Editors

Zeeshan Fatima

Dr Zeeshan Fatima is currently Associate Professor at the Amity Institute of Biotechnology, Amity University Haryana, India. Dr Fatima took her bachelor’s and master’s degrees at Banaras Hindu University, in 2000 and 2002, respectively. She earned her doctoral degree in biochemistry from Aligarh Muslim University, in 2008. She has held research positions under nationally and internationally funded research projects, which include her postdoctoral work in 2010, at the University of Cincinnati, Ohio, USA. In 2012, Dr Fatima received two Young Scientist awards under fast-track and women scientist schemes, respectively, from the Science and Engineering Research Board, Department of Science and Technology, New Delhi, India.  Additionally, she has acquired regular projects for funding from the Board of Research in Nuclear Sciences, Mumbai, the Ministry of AYUSH, and DBT, New Delhi, India. She is actively engaged in research in the field of infectious diseases, in particular, Mycobacterium tuberculosis. She has 45 peer-reviewed papers to her credit in international and national journals of repute and has authored three books. She has successfully convened three national conferences as organizing secretary. She has supervised four PhD students and guided 25 undergraduate and postgraduate students in their research projects. She is life member of the International Society of Infectious Diseases, the Association for Microbiologists, India, and the Society of Biological Chemists, India

Affiliations and Expertise

Associate Professor, Amity Institute of Biotechnology, Amity University Haryana, Gurugram, India

Stéphane Canaan

Dr. Stéphane Canaan is currently Director of Research at the CNRS in the Laboratory of Engineering of Macromolecular Systems, Marseille, France. Dr Canaan has been working for 26 years in the field of lipolytic enzymes, his main interest being to decipher their physiological functions and biochemical mechanisms of action in several organisms. He earned his doctoral degree in biochemistry and cellular biology from Aix-Marseille University, in 1999. In 2000, he received the GERLI prize for his thesis. He spent five years as a post-doctoral fellow, three years at Seattle University, USA, and two years in the AFMB lab in Marseille, France. He acquired a permanent position at CNRS in 2004. He has published 87 papers in peer-reviewed journals and has three patents in this field. Since 2004, he has headed the Lipolysis and Bacterial Pathogenicity team, consisting of 9-10 members, whose main research topics involve characterizing the lipolytic enzymes in lipid metabolism of pathogenic mycobacteria (Mycotuberculosis, Mycoabscessus, Mycoulcerans, etc.), to develop specific and potent inhibitors of these enzymes, thus opening new possibilities of controlling mycobacterial infections. In 2015, he organized a mycobacterial meeting with 160 participants. The team is internationally recognized in the field of biochemistry of mycobacterial lipases. Since 2006, Dr Canaan has obtained more than 15 projects, 9 as principal investigator and 6 as partner. Moreover, since 2005, he has supervised 10 PhD students, 3 currently in progress, and more than 60 graduate and undergraduate students.

Affiliations and Expertise

Director of Research, Universite Aix-Marseille, CNRS, LISM, Institute de Microbiologie de la Mediterrannee, Marseille, France

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