Biointegration: An introduction. Part 1 Soft tissue biointegration: Biocompatibility of engineered soft tissue created by stem cells; Replacement materials for facial reconstruction at the soft tissue-bone interface; Corneal tissue engineering; Tissue engineering for small-diameter vascular graft; Stem cells for organ regeneration. Part 2 Drug delivery: Materials facilitating protein drug delivery and vascularisation; Inorganic nanoparticles for targeted drug delivery; Alginate-based drug delivery devices; Functionalised nanoparticles for targeted drug delivery. Part 3 Design considerations: Biocompatibility of Materials and its relevance to drug delivery and tissue engineering; Mechanisms of failure of medical implants during long-term use; Rapid prototyping in biomedical Engineering: Structural intricacies of biological materials.
Biointegration is essential for the successful performance of implanted materials and devices within the human body. With an increasing number and wide range of implant procedures being performed, it is critical that materials scientists and engineers effectively design implant materials which will create a positive biological and mechanical response with the host tissue.
Biointegration of medical implant materials provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration. Part one discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering and vascular grafts. Part two then reviews particular techniques in drug delivery including inorganic nanoparticles for targeted drug delivery and alginate based drug delivery devices. Part three covers design considerations with coverage of themes such as biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long term use and rapid prototyping in biomedical engineering.
With its distinguished editor and team of international contributors, Biointegration of medical implant materials: science and design is a standard reference for medical materials scientists and engineers in industry and the academic sector.
- Provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration
- Discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, vascular grafts and replacement materials for facial reconstruction
- Reviews particular techniques in drug delivery featuring inorganic nanoparticles and functionalized nanoparticles for targeted drug delivery
Medical materials scientists and engineers in industry and the academic sector
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- © Woodhead Publishing 2010
- 13th July 2010
- Woodhead Publishing
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Chandra P. Sharma is the Acting Head of Biomedical Technology Wing and Associate Dean - PhD Programme, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala, India, and has been the Head of the Biosurface Technology Division since 1980. His areas of expertise include: biomaterials science and engineering; polymeric and metallic micro/nano particles based delivery systems; and surface modification and tissue/blood compatibility of materials. Dr. Sharma has published over 325 research papers with over 2600 citations (Scopus) and has processed 32 patents including in Canada, European Union, Japan and USA. He has served as guest editor and reviewer of several international journals and has edited books with Dr. Michael Szycher on Blood Compatible Materials and Devices, and on Biointegration of medical implant materials: Science and design, with Woodhead Publishing. His laboratory has completed leading research in the field.
Sree Chitra Tirunal Institute for Medical Sciences and Technology, India