Autophagy in Health and Disease

2nd Edition - September 22, 2021
Editors: Beverly Rothermel, Abhinav Diwan
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 0 0 3 - 0
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 2 0 0 4 - 7

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expand… Read more

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Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target.

Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study.

Section I - Overview

1. Introduction
Beverly A. Rothermel and Abhinav Diwan

2. Mechanisms of autophagy: the machinery of macroautophagy and points of control
Congcong He

3. Regulation of autophagy - transcriptional, posttranscriptional, translational, and posttranslational mechanisms
Logan Slade and Thomas Pulinilkunnil

4. Selectivity and trafficking of autophagic cargoes
Nuzhat Ahsan, Kautilya Kumar Jena, Subhash

5. The role of lysosomes in autophagy
Yoana Rabanal-Ruiz and Viktor I. Korolchuk

6. Methods for measuring autophagy
Allen Andres

7. Effects of physiologic inputs on autophagy
Tobias Eisenberg, Mahmoud Abdellatif, Senka Ljubojević-Holzer and Simon Sedej

Section II - Development

8. Autophagy in germ cells, stem cells, and induced pluripotent stem cells
Moydul Islam, Ngoc Uyen Nhi Nguyen, Abhinav Diwan and Beverly A. Rothermel

9. Role of autophagy in embryogenesis
Takayuki Tatsumi and Satoshi Tsukamoto

10. Autophagy in hematopoiesis and leukemogenesis
Angela Ianniciello and G. Vignir Helgason

11. Autophagy in cell plasticity with particular focus on paligenosis
Megan D. Radyk, Lillian B. Spatz and Jason C. Mills

Section III - Metabolic control and diabetes

12. Autophagy in the liver
Mark Li and Ling Yang

13. Autophagy in adipose tissue
Vishaka Vinod and Sihem Boudina

14. Autophagy in the pancreas
Amelia Williams, Merilin Georgiou and Catherine Arden

15. Skeletal muscle
Greg R. Markby and Kei Sakamoto

Section IV – Cardiovascular System

16. Autophagy in the cardiovascular system
Daniel Peñ-Oyarzún, Valeria Garrido-Moreno, Luis Garrido-Olivares, Ramon Corbalan, Alfredo Criollo and Sergio Lavandero

17. Lungs
Poornima Mahavadi, Martina Korfei and Andreas Guenther

18. Autophagy in the vasculature
Bieke Steenput, Cédric HG. Neutel, Nina Hermans, Wim Martinet, Guido R.Y. De Meyer, Pieter-Jan Guns and Lynn Roth

Section V - The nervous system and neurodegeneration

19. Altered autophagy on the path to Parkinson's disease
Irene Sanchez-Mirasierra, Sergio Hernandez-Diaz, Saurav Ghimire, Patrick Main and Sandra-Fausia Soukup

20. Autophagic processes in early- and late-onset Alzheimer's disease
Chenglong Xie, Yahyah Aman, Johannes Frank, Maria Jose Donate-Lagartos, Ruben Gudmundsrud, Kateřina Čechová, Liu Shi, Martin Vyhnalek and Evandro F. Fang

Section VI – Homeostasis and disease in other organ systems

21. Autophagy as an integral immune system component
Elizabeth Bueno, Samuel Wyatt, Robyn Duttenhefner, Daniel Asa, Srinivasulu Dasanna and Sangita C. Sinha

22. Autophagy in the gastrointestinal system and cross talk with microbiota
Felipe X. Pimentel-Muiños

23. Role of autophagy in building and maintaining the skeletal system
Olivier Camuzard, Marie-Charlotte Trojani, Georges F. Carle and Vale´rie Pierrefite-Carle

24. Autophagy on the road to longevity and aging
Maria Manifava and Nicholas T. Ktistakis

25. Autophagy in cancer: friend or foe?
Silvia Vega-Rubín-de-Celis

26. Mammalian microautophagy: mechanism and roles in disease
Takahiro Seki and Hiroshi Katsuki

27. Chaperone-mediated autophagy - mechanisms and disease role
Amelina Albornoz, Alvaro Sequeida, Christian Rodríguez and Mauricio Budini

28. Targeting autophagy: lifestyle and pharmacological approaches
Alfredo Briones-Herrera, Tania Gómez-Sierra, Elena Martínez-Klimova, Belén Bellido and José Pedraza-Chaverr

Beverly Rothermel

Bev Rothermel, PhD, is an Associate Professor at the University of Texas Southwestern Medical Center in Dallas, TX, with appointments in the Departments of Internal Medicine (Cardiology) and Molecular Biology. Her laboratory was directly involved in some of the first studies demonstrating the dual nature of autophagy in the cardiovascular system. She has lectured on the role of autophagy in human disease for more than ten years as a component of the graduate school’s Integrative Biology program. Current studies in her lab seek to understand circadian regulation of cardiac mitophagy as well as identify the causes and consequences of suppressed autophagy in Down syndrome. Her research is supported by the National Institutes of Health’s INCLUDE Project, the Wellstone Muscular Dystrophy Research Network, and the American Heart Association.

Affiliations and expertise

Associate Professor, Department of Internal Medicine | Molecular Biology, UT Southwestern Medical Center, USA

Abhinav Diwan

Abhinav Diwan, MBBS, is a physician-scientist and a board-certified cardiologist, and directs a laboratory-based research program focused on basic and translational studies to therapeutically target the autophagy-lysosome pathway in human disease. He is Professor of Medicine, Cell Biology and Physiology, and Obstetrics and Gynecology at Washington University in Saint Louis, Missouri, USA and Staff Physician at the John Cochran Veterans Affairs Medical Center in Saint Louis. Studies from his laboratory have uncovered evidence for acquired lysosome dysfunction as a common cellular in cardiomyopathy and heart failure, Alzheimer’s disease and diabetes. Translational research from his program has established the autophagy-lysosome pathway as a viable therapeutic target, with activation of the lysosome biogenesis program as an exciting strategy in these conditions. He has also proven to be an outstanding mentor to the next generation of physician-scientists, an effort he leads as the program director of the Investigator Training Pathway in the Cardiovascular Division supported by a NIH T32 training grant.

Affiliations and expertise

Professor of Medicine, Cell Biology and Physiology, Center for Cardiovascular Research, Washington University School of Medicine in St. Louis, USA; and Staff Physician, John Cochran Veterans Affairs Medical Center in Saint Louis, Missouri, USA