Advances in Heterocyclic Chemistry
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Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight to yield an understanding of how the chemistry drives the properties.Degenerate ring transformations of heterocycles are classified as reactions in which a heterocyclic system is converted into the same heterocyclic system. This monograph covers an authoritative, comprehensive overview of a host of degenerate ring transformations in five- and six-membered heterocycles. It shows how by the use of 15N-labeled, 13C-labeled, or selectively substituted compounds these degenerate rign transformations can be discovered and how most of the results can be explained by the Addition Nucleophile, Ring Opening, and Ring Closure [ANRORC] mechanism. Another main topic of the monograph is the occurrence of degenerate ring transformations.
Organic chemists, pharmacologists, medicinal chemists, photographic chemists, and agrochemists.
Table of Contents
- Introduction. SN (ANRORC) Reactions in Azines, Containing an "Outside" Leaving Group. The Discovery of the SN (ANRORC) Concept. SN(ANRORC) Substitutions in Mono Azines. SN(ANRORC) Substitutions in Dlazines. SN(ANRORC) Substitutions in Triazines and Tetrazines. SN (ANRORC) Reactions in Azaheterocycles, Containing an "Inside" Leaving Group. Degenerate Ring transformations, Involving the Replacement of the Nitrogen of the Azaheterocycle by Nitrogen of the Reagent. Degenerate Ring Transformations, Involving the Replacement of a C-N Fragment of the Pyrimidine Ring by a C-N Moiety of a Reagent. Degenerate Ring Transformations, Involving the Replacement of a Three-Atom Fragement of the Heterocyclic Ring by a Three-Atom Moiety of a Reagent. Degenerate Ring Transformation, Involving the Replacement of a Carbon Atom of the Heterocyclic Ring by a Carbon Atom of the Reagents. Degenerate Ring Transformations by Side-Chain Participation. Introduction. Degenerate Ring Transformations, Involving the Participation of a Side-Chain with One Atom. Degenerate Ring Transformations, Involving the Participation of a Side-Chain with Two Atoms. Degenerate Ring Transformations, Involving the Participation of a Side-Chain with Three Atoms.
- No. of pages: 253
- Language: English
- Copyright: © Academic Press 1999
- Published: July 21, 1999
- Imprint: Academic Press
- eBook ISBN: 9780080524443
About the Serial Editors
Henk van der Plas
Professor Dr. H.C. van der Plas received his Ph.D. from the University of Amsterdam. He has served the Agricultural University at Wageningen, The Netherlands, from 1966 as a Reader, from 1970 as Professor of Organic Chemistry, and from 1978-1982 and 1989-1995 as Rector Magnificus. His research interest is in chemistry, mainly in the field of nucleophilic substitution and ring transformations. The results of his scientific results are set down in nearly 400 research papers, 20 review articles, and in two monographs, and a book (together with O. Chupakhin and V. Charushin), Nucleophilic Substitution of Aromatic Hydrogen.
Affiliations and Expertise
Wageningen Agricultural University, The Netherlands
Alan Katritzky was educated at Oxford and has held faculty positions at Cambridge and East Anglia before he migrated in 1980 to the University of Florida, where he was Kenan Professor and Director for the Institute for Heterocyclic Compounds. During his career he has trained more than 1000 graduate students and post-docs, and lectured and consulted world-wide. He led the team, which produced “Comprehensive Heterocyclic Chemistry” and its sequels, "CHEC-II" and "CHEC-III”, has edited “Advances in Heterocyclic Chemistry, Vols. 1 through 111” and conceived the plan for “Comprehensive Organic Functional Group Transformations”. He founded Arkat-USA, a non-profit organization which publishes “Archive for Organic Chemistry” (ARKIVOC) an electronic journal completely free to authors and readers at (www.arkat-usa.org). Honors include 14 honorary doctorates from 11 countries and membership of foreign membership of the National Academies of Britain, Catalonia, India, Poland, Russia and Slovenia.
Affiliations and Expertise
Department of Chemistry, University of Florida, Gainesville, USA
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