Viscoelasticity and Collective Cell Migration

Viscoelasticity and Collective Cell Migration

An Interdisciplinary Perspective Across Levels of Organization

1st Edition - January 13, 2021

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  • Editors: Ivana Pajic-Lijakovic, Elias Barriga
  • eBook ISBN: 9780128203118
  • Paperback ISBN: 9780128203101

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Viscoelasticity and Collective Cell Migration: An Interdisciplinary Perspective Across Levels of Organization focuses on the main viscoelastic parameters formulated based on multiscale constitutive modeling and how to measure these rheological parameters based on existent micro-devices such as micro-rheology and micro-elastography. The book sheds light on inter-relationships across viscoelasticity scales, an essential step for understanding various biomedical processes such as morphogenesis, wound healing and cancers invasion. Cumulative effects of structural changes at subcellular and cellular levels influence viscoelasticity at a supracellular level are also covered, providing valuable insights for biologists, physicists, engineers, students and researchers in the field of developmental biology. As this is a complex multidisciplinary field, perspectives are included from experts in biology, biochemistry, biomedicine, biophysics and biorheology. Readers will gain a deeper understanding of the complex dynamics that represent challenges and the necessity for further development in the field.

Key Features

  • Discusses the biological/biochemical mechanisms of collective cell migration
  • Covers the inter-relation between collective cell migration and viscoelasticity by proposing rheological parameters
  • Contains critical consideration of various experimental techniques that are suitable to measure these parameters


Research Scientists/ Engineers and Graduate Students working in the field of Viscoelasticity

Table of Contents

  • 1. Viscoelastic Impedance of Cells and Tissues -Basic Concepts and Physiological Functions
    Erich Sackmann and Florian Rehfeld
    2. Recent advances in imaging of cell elasticity
    Guy Cloutier
    3. Biophysical origins of viscoelasticity during collective cell migration
    Andrew Clark
    4. Intrinsic and extrinsic viscoelasticity modulates cell migration in vivo
    Elias Barriga
    5. Effects of time delays and viscoelastic parameters in oscillatory response cell monolayers
    Jose J Munoz
    6. Mechanical changes driving 3D cell motility in development and cancer
    Timo Betz
    7. Comparing interfacial, viscous and elastic contributions during 3D cell aggregate rearrangements
    Yasuji Sawada, Jean-Paul Rieu, Olivier Cochet Escartin, Helene Delanoe-Ayar
    8. Viscoelasticity of multicellular systems caused by collective cell migration: multi scale modelling considerations
    Ivana Pajic-Lijakovic and Milan Milivojevic
    8. Flow dynamics of 3D multicellular systems under confinement
    Karine Guevorkian and David Gonzalez-Rodriguez
    9. Multicellular systems response under stress: From subcellular to supracellular levels
    Ivana Pajic-Lijakovic and Milan Milivojevic
    10. Cytoskeletal and cell adhesion contributions to tissue stresses
    Gregory Weber
    11. Confinement-induced transition between wave-like collective cell migration modes
    Giovanni Cappello, Thomas Boudou and Martial Balland

Product details

  • No. of pages: 314
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: January 13, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128203118
  • Paperback ISBN: 9780128203101

About the Editors

Ivana Pajic-Lijakovic

Dr. Ivana Pajic-Lijakovic is a scientific advisor. Her research interest is related to biological physics, biorheology and biomechanics. She worked as guest editor for Seminars and Cell and Developmental Biology for the special issue titled: “Viscoelasticity of multicellular systems: from subcellular to supracellular levels”

Affiliations and Expertise

Department of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Serbia

Elias Barriga

Dr. Elias Barriga is a former University College London postdoc and current group leader at Instituto Gulbenkian de Ciencia (IGC), Portugal Lisbon. His research focuses in understanding how mechano-molecular interactions synchronise morphogenesis in development and regeneration.

Affiliations and Expertise

Group Leader, Instituto Gulbenkian de Ciencia (IGC), Lisbon, Portugal

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