Translational Immunotherapy of Brain Tumors - 1st Edition - ISBN: 9780128024201, 9780128026250

Translational Immunotherapy of Brain Tumors

1st Edition

Editors: John H. Sampson
eBook ISBN: 9780128026250
Hardcover ISBN: 9780128024201
Imprint: Academic Press
Published Date: 2nd March 2017
Page Count: 404
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
108.00
75.60
75.60
75.60
75.60
75.60
86.40
86.40
91.00
63.70
63.70
63.70
63.70
63.70
72.80
72.80
150.00
105.00
105.00
105.00
105.00
105.00
120.00
120.00
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors.

Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike.

Key Features

  • Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas
  • Edited by a prominent neurosurgeon with contributions by leading researchers in the field
  • Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

Readership

Researchers and practitioners in the fields of neuroscience, neurology, neurooncology, and neurosurgery

Table of Contents

Section I. Immunological Features of Brain Tumors

Chapter 1. An Introduction to Immunotherapy in the Treatment of Brain Tumors

  • Introduction
  • The Immune Response
  • Immune Tolerance
  • Unique Aspects of the Central Nervous System Immune Response
  • Cancer Immunotherapies

Chapter 2. Immune Constitution of Patients With Brain Tumors

  • Background and Discovery
  • Current Understanding: Analyzing Systemic Immune Dysfunction
  • Current Understanding: Analyzing the Tumor
  • Clinical Opportunities
  • Conclusion

Chapter 3. The Role of Regulatory T Cells and Indoleamine-2,3-dioxygenase in Brain Tumor Immunosuppression

  • Background and Discovery
  • Origin of Tregs
  • Function of Tregs
  • Tregs in the Cancer Immunity Cycle
  • Tregs and Glioma
  • Tryptophan Catabolism in Immunity and in Cancer
  • IDO1, IDO2, and TDO
  • The AhR
  • Mechanisms of Immune Regulation by the IDO Pathway
  • The IDO Pathway in Cancer and in Glioma
  • Targeting Tregs in Preclinical Model
  • Targeting IDO in Preclinical Models
  • Clinical Trial Data
  • Conclusion

Chapter 4. The Role of Myeloid-Derived Suppressor Cells in Immunosuppression in Brain Tumors

  • Background and Discovery of the Myeloid Cell
  • Preclinical Data: Targeting the MDSC Population
  • Clinical Approaches to Targeting MDSCs

Chapter 5. Tumor-Specific Mutations in Gliomas and Their Implications for Immunotherapy

  • Introduction
  • Mutations as Immunotherapeutic Targets
  • Isocitrate Dehydrogenase 1 Mutations in Gliomas
  • IDH1 Mutations as an Immunotherapeutic Target
  • Preclinical Investigations: IDH1-R132H Peptide Vaccines
  • Clinical Investigations: IDH1-R132H Peptide Vaccines
  • Roadblocks and Future Directions for Targeting IDH1 Mutations
  • Epidermal Growth Factor Receptor and Variant III in Gliomas
  • EGFR Mutations as an Immunotherapeutic Vaccination Target
  • Preclinical Investigations: EGFRvIII Vaccination
  • Clinical Investigations: EGFRvIII Vaccination
  • Roadblocks for Targeting EGFRvIII
  • Histone Mutation Background
  • Histone Mutations in Pediatric Gliomas
  • H3.3 Mutations as an Immunotherapeutic Target
  • Roadblocks and Future Directions for Targeting H3 Mutations

Section II. Studying Brain Tumor Immunotherapy

Chapter 6. Preclinical Immunotherapeutic Animal Models for Brain Tumors

  • Introduction
  • Spontaneous and Experimentally-Induced Autochthonous Brain Tumor Animal Models
  • Syngeneic Transplantation Brain Tumor Models
  • Genetically Engineered Mouse Models
  • Xenograft Models of Glioblastoma
  • Humanized Mouse Models
  • Conclusion

Chapter 7. Imaging Studies in Immunotherapy

  • Clinical Considerations
  • Advanced Imaging Assessments
  • Conclusion

Chapter 8. Immunotherapy Clinical Trials in Neuro-Oncology

  • Introduction
  • Early Immunotherapy
  • Immunotherapy in the 21st Century
  • Checkpoint Inhibitors
  • Therapeutic Cancer Vaccines
  • Chimeric Antigen Receptor T Cells
  • Viral Therapy in Solid Tumors
  • Bispecific T Cell Engagers
  • Immunotherapy Clinical Trial Design in Neuro-Oncology
  • Study Design
  • Assessing the Candidate
  • Assessment of Safety
  • Assessment of Response

Section III. Experimental Brain Tumor Immunotherapies

Chapter 9. Peptide-Specific Vaccines

  • Background and Discovery
  • Preclinical Data and Principles of Peptide Vaccines
  • Clinical Trial Data
  • Wilms Tumor Peptide 1
  • Vaccination Targeting IDH-1R132H
  • Multipeptide Vaccination Regimens
  • Conclusion

Chapter 10. Immunotoxin Therapy for Brain Tumors

  • Introduction
  • History of Immunotoxins
  • Immunotoxins for Brain Tumor Therapy
  • Future Directions
  • Conclusion

Chapter 11. Checkpoint Blockade Immunotherapy for Glioblastoma: Progress and Challenges

  • The Tumor Immune Response and Immune Checkpoint Biology
  • Immune Checkpoints in Malignant Glioma
  • Immune Checkpoint Blockade
  • Feasibility of Checkpoint Blockade for Central Nervous System Malignancies
  • Clinical Progress of Checkpoint Blockade for Glioblastoma
  • Emerging Targets for Checkpoint Blockade
  • On the Horizon: Immunomodulatory Antibodies for T Cell Costimulation
  • Conclusion

Chapter 12. Dendritic Cell Therapy for Brain Tumors

  • Introduction
  • Tumor Microenvironment
  • Dendritic Cells in Immunology
  • Dendritic Cell–Based Vaccine: Current Approaches
  • Antigen Targets
  • Routes of Administration
  • Safety and Complications
  • Immune Response
  • Clinical Response and Survival Benefits
  • Radiologic Findings
  • Clinical Trials
  • Future Directions
  • Conclusion

Chapter 13. Adoptive Immunotherapy Against Brain Tumors

  • Introduction
  • Approaches

Chapter 14. Chimeric Antigen Receptor Therapy of Brain Tumors

  • Chimeric Antigen Receptors Through the Generations
  • Success of Targeting Hematogenous Malignancies: CD19 Chimeric Antigen Receptors
  • Solid Tumors as a Chimeric Antigen Receptor Target
  • Chimeric Antigen Receptor Therapy for Brain Tumors
  • The Question of Delivery
  • Potential Challenges
  • Future Perspectives

Details

No. of pages:
404
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128026250
Hardcover ISBN:
9780128024201

About the Editor

John H. Sampson

John H. Sampson

John H. Sampson, MD, PhD, MBA

Dr. Sampson is the Robert H. and Gloria Wilkins Distinguished Professor of Neurosurgery and Chair of the Department of Neurosurgery for the Duke University Medical Center. He holds a leadership role in the Duke Cancer Institute’s Neuro-Oncology Program and is a recognized leader in the surgical and experimental treatment of brain tumors with a focus on immunotherapy and drug delivery. He has authored more than 220 peer-reviewed publications in this field and serves on the Editorial Boards of the all the major journals in the field.

Dr. Sampson has received special training in the surgical resection of very complex brain tumors. In addition, he has special training in the design and conduct of clinical trials. He did his research training under the internationally renowned scientist, Darell D. Bigner, and Nobel Laureate, Gertrude Elion. He currently focuses his clinical practice on treating patients with both benign and malignant brain tumors and divides his time between his clinical practice and an active research laboratory investigating new modalities of direct brain tumor infusion and immunotherapy.

Dr. Sampson is internationally recognized in the field of neurosurgery and has received a number of national and international awards and grants in recognition of his expertise in neuro-oncology and especially in the area of immunotherapy for brain tumors. He developed a vaccine against a common mutation in brain tumors that was given Breakthrough Therapy Designation by the FDA after it was shown to extend survival in patients with the most malignant form of brain cancer. His work on another vaccine was also recently published in the journal Nature. His work has been highlighted on the CBS Evening News, 60 Minutes, The Wall Street Journal, and The Diane Rehm Show.

Affiliations and Expertise

Robert H. and Gloria Wilkins Professor of Neurosurgery, Chair, Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA