Tissue Engineering

Tissue Engineering

3rd Edition - October 1, 2022

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  • Editors: Clemens Van Blitterswijk, Jan De Boer
  • Hardcover ISBN: 9780128244593

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Tissue Engineering, Third Edition provides a completely revised release with sections focusing on Fundamentals of Tissue Engineering and Tissue Engineering of Selected Organs and Tissues. Key chapters are updated with the latest discoveries, including coverage of new areas (skeletal TE, ophthalmology TE, immunomodulatory biomaterials and immune systems engineering). The book is written in a scientific language that is easily understood by undergraduate and graduate students in basic biological sciences, bioengineering and basic medical sciences, and researchers interested in learning about this fast-growing field.

Key Features

  • Presents a clear structure of chapters that is aimed at those new to the field
  • Includes new chapters on immune systems engineering, skeletal tissue engineering (skeletal muscle, tendon, and ligament) eye, cornea and ophthalmology tissue engineering
  • Includes applied clinical cases studies that illustrate basic science applications


Students and practitioners/researchers in basic biological sciences, bioengineering, and basic medical sciences. Undergraduate and Master's programs in biomedical engineering

Table of Contents

  • Part I. The Fundamentals of Tissue Engineering (TE)
    1. Tissue Engineering: An Introduction
    2. Ethical Issues in Tissue Engineering
    3. Stem Cells
    4. Tissue Formation during Embryogenesis
    5. Cellular Signaling
    6. Extracellular Matrix (ECM) as a Bioscaffold for Tissue Engineering
    7. Cell–Material Interactions
    8. Materiomics: A Toolkit for Developing New Biomaterials
    9. Biomaterial Design and Fabrication
    10. Biomaterial Degradation Kinetics
    11. Microfabrication Technology in Tissue Engineering
    12. Bioreactors: Enabling Technologies for Research and Manufacturing
    13. Controlled Release Strategies in Tissue Engineering
    14. Clinical Grade Production of Mesenchymal Stromal Cells

    PART II. Tissue engineering of selected organs and tissues
    15. Vascularization, Survival, and Functionality of Tissue-Engineered Constructs
    16. Tissue engineering of heart, lung and blood vessels
    17. Cartilage and Bone Regeneration
    18. Skeletal tissue engineering: skeletal muscle, tendons and ligaments
    19. Skin Engineering and Keratinocyte Stem Cell Therapy
    20. Tissue Engineering of the Nervous System
    21. Ophthalmology Tissue Engineering: regeneration of retina, cornea and other elements of the eye
    21. Organs-on-a-Chip
    22. Tissue Engineering of Organ Systems
    23. Product and Process Design: Toward Industrial TE Manufacturing

Product details

  • No. of pages: 900
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: October 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128244593

About the Editors

Clemens Van Blitterswijk

Clemens Van Blitterswijk
Clemens van Blitterswijk graduated as cell biologist from Leiden University in 1982, defending his PhD thesis in 1985 at the same university. Today his research focuses on tissue engineering and regenerative medicine, forming a unique basis of multidisciplinary research between materials and life sciences. Van Blitterswijk has authored and co-authored more than 380 peer reviewed papers (H index 90, Scopus); is one of the most frequently cited Dutch scientists in TE; the applicant and co-applicant of over 100 patents; has guided 50 PhD candidates through their thesis as supervisor or co-supervisor and currently has 30 PhD candidates under his supervision. Dr. van Blitterswijk received a number of prestigious international awards including the George Winter award of the European society for Biomaterials, the Career Achievement Award of the Tissue Engineering and Regenerative Medicine International Society and is a member of the KNAW (The Royal Netherlands Academy of Arts and Sciences).

Affiliations and Expertise

KNAW (The Royal Netherlands Academy of Arts and Sciences), The Netherlands

Jan De Boer

Jan De Boer
Jan de Boer is an experienced University Professor and Chief Scientific Officer with a demonstrated history of working in academia and biotech. As a research professional he is skilled in Stem Cells, Biomaterial Engineering and Regenerative Medicine.  Jan is interested in the molecular complexity of cells and how molecular circuits are involved in cell and tissue function. With a background in mouse and Drosophila genetics, he entered the field of biomedical engineering in 2002 and has since focused on understanding and implementing molecular biology in the field of tissue engineering and regenerative medicine. His research is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology, to streamline the wealth of biological knowledge to real clinical applications.

Affiliations and Expertise

Professor, Department of Biomedical Engineering, The Netherlands

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