The Neuroscience of Parkinson's Disease

The Neuroscience of Parkinson's Disease

1st Edition - September 23, 2020

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  • Editors: Colin Martin, Victor Preedy
  • eBook ISBN: 9780128159590
  • Hardcover ISBN: 9780128159583

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The Neuroscience of Parkinson’s Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

Key Features

  • Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease
  • Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
  • Serves as a "one-stop" source for everything you need to know about Parkinson’s disease


Neuroscientists/neurologists, psychologists, health scientists, public health workers, research scientists, pharmacologists, and physicians. Graduate/postgraduate students, lecturers, and professors

Table of Contents



    Virginia Bottomley


    I. Introductory Chapters and Setting the Scene

    1. Progression of symptoms in Parkinson's disease

    Lucilla Parnetti

    2. Cellular pathophysiology and basal ganglia dysfunction in Parkinson's disease: An Overview

    Heinz Reichmann and Kai Felix Loewenbrueck

    3. The role of environmental toxins and inflammation in Parkinson’s disease pathophysiology: a historical perspective and research-based evidence

    Heinz Reichmann and Kai Felix Loewenbrueck

    4. Risk factors in Parkinson's Disease: genetic and nongenetic

    Evangelos Evangelou

    5. Recent developments in the etiology, treatment and potential therapeutic targets for Parkinson's Disease: a focus on biochemistry

    Athanasios Alexiou

    6. Facial emotions and Parkinson's disease

    G. Di Gennaro and Marco De Risi

    7. The role of the circadian system in Parkinson’s Disease

    G. Willis

    8. Parkinson's disease and social media

    Ibrahim S. Al-Busaidi

    9. Sleep in Parkinson's disease

    Marcelo M. S. Lima

    10. Recurrent falls in Parkinson's disease

    Lorena Rosa Santos de Almeida

    11. Parkinsons patients deciding their own treatment

    J. Koerts

    12. Visual impairment in Parkinson's disease

    Alessandro Arrigo

    13. Autonomic problems in Parkinson’s disease: a focus on the bladder

    Ryuji Sakakibara

    14. Autonomic problems in Parkinson’s disease: a focus on the bowel

    Ryuji Sakakibara

    15. Linking and comparing nonmotor symptoms in ageing and Parkinson’s disease

    Petra Bago Rozankovic

    16. Progression of motor symptoms in Parkinson's Disease

    Joana Ribeiro and Daniela Vieira

    17. The stigma of Parkinson's disease

    Benjamin K.P. Woo

    II. Biomarkers, Instruments, Diagnosis and Assessments

    18. Better neuroradiological approaches for the diagnosis of early stage Parkinson's disease patients

    Tatsuro Mutoh

    19. Use of positron emission tomography (PET) as a diagnostic and differential diagnostic tool in Parkinsonian syndromes

    Maja Trost

    20. Finger typing for the detection of early Parkinson's Disease

    Warwick Adams

    21. CSF biomarkers of Parkinson's disease

    P. Lewitt

    22. Application of eye movement tasks as an aid to understanding Parkinson's disease pathophysiology

    Kikuro Fukushima

    23. Measuring quality of life

    Pablo Martinez Martin and Camen Rodriquez-Blazquez

    24. Clinically assessing cognitive function in Parkinson’s disease

    Ryan Anderton

    III. Pharmacological Treatments, Other Agents and Strategies

    25. Good news for the drug therapy of Parkinson`s disease

    L. Bergantin

    26. Dopamine Agonists and Parkinson’s disease: an overview

    Aloke K. Dutta

    27. Management with apomorphine in Parkinson’s disease

    Manon Auffret

    28. Management with MAO-B Inhibitors in Parkinson’s disease

    T. Mueller

    29. Management with antibiotics in Parkinson’s disease

    Elaine Del-Bel and Mariza Bortolanza

    30. Administration of dopamine in the brain in Parkinson’s disease

    David Devos

    31. Placebo and nocebo effects in Parkinson's disease

    Fabrizio Benedetti

    32. Levodopa-induced dyskinesias

    N. S. Narayanan and Stephanie Alberico

    33. Cannabinoid receptor type 2 as a therapeutic target for Parkinson’s disease

    Miguel Abellanas and M. Aymerich

    IV. Non-Pharmacological, Novel and Other Treatment Procedures

    34. Deep Brain Stimulation Surgery in Parkinson's Disease

    Hesham Abboud

    35. Gene delivery for Parkinson’s disease

    M. Airavaara and Andrii Domanskyi

    36. Transdifferentiation of glial cells into dopamine neutrons via viral vectors/ Introducing transgenes into cells into the brain

    M. Airavaara and Andrii Domanskyi

    37. Urso- and tauroursodeoxycholic acids as anti-apoptotic agents: Modulation of Parkinson's disease

    Noha Abdelkader

    38. Interlinking potential therapy with botulinum neurotoxin A and Parkinson's disease

    Andreas Wree

    39. Neuropeptide CART (cocaine-amphetamine-regulated transcript) and usage in Parkinson's disease

    P. Mao

    40. Photobiomodulation as a neuroprotective strategy for Parkinson’s disease

    Daniel M. Johnstone

    41. Assisted devices in Parkinson's disease

    Roongroj Bhidayasiri





    Virginia Bottomley


    I. Genetics, Molecular and Cellular Biology

    1. LRRK2 genes in Parkinson’s disease: from genetics to pathobiology

    Elisa Greggio and Susanna Cogo

    2. Alpha-synuclein gene and Parkinson’s disease

    Leonidas Stefanis

    3. The DJ-1 gene and protein: links with Parkinson's Disease

    Paul R. Fisher

    4. Gene expression in the connection between 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and tyrosine hydroxylase

    Gelareh Alam and Jason Richardson

    5. Linking GBA variants and Parkinson's disease

    Mathias Toft

    6. Astrocytes and microglia in Parkinson’s disease and its animal models

    Katarzyna Z. Kuter

    7. Autophagy in Parkinson’s disease

    Sandra Morais Cardoso and Nilza Manadas

    8. Mitochondria in Parkinson’s disease

    Sabrina Buettner

    9. Signal transduction in Parkinson's disease

    Mattia Volta

    10. Oxidative stress signaling and regulated cell death in Parkinson’s disease

    Marlene Jimenez-Del-Rio and Carlos Velez-Pardo

    11. Subcellular-specific alpha-synuclein in Parkinson's Disease

    Simon Geir Moller and Benjamin Rosen

    12. MC1R in Parkinson's disease and association with melanoma risk

    Susana Puig and Gemma Tell-Marti

    13. Energy regulation and Parkison's disease

    Kah-Leong Lim

    14. Linking rotigotine, Parkinsons disease and brain BDNF

    H. Kunugi

    II. Neurology, Physiology and Imaging

    15. The different syndromes in Parkinson’s disease: an overview

    Maria Stamelou and Nikolaos Giagkou

    16. Neuromolecular imaging in Parkinson’s disease

    P. Broderick

    17. Interlinking brain mapping and Parkinson's disease: MRI analysis, nigrosome 1 and nigrosome 4

    Eung Yeop Kim

    18. Interconnecting Parkinson’s disease, computed tomography (CT) and microelectrode recording in deep brain stimulation

    Sepehr Sani and Ryan B. Kochanski

    19. Linking diffusion tensor imaging (DTI), microstructures and Parkinson’s disease

    Yu Zhang

    20. Hypointensity in the substantia nigra pars compacta in Parkinson’s disease

    Xiaoping Hu and Jason Langley

    21. Vagal motoneurons in Parkinson’s disease

    Joshua A. Goldberg and Ruth Musgrove

    22. Circadian clock disruption and neuroinflammation in Parkinson’s disease: a new perspective

    Elisabetta Lauretti and Domenico Pratico

    23. Motor cortex stimulation in Parkinson’s disease

    A. Lavano

    24. Action programming disorders associated with Parkinson's Disease

    Kenneth M. Heilman

    25. The striatal medium spiny neurons (MSNs): what they are and how they link with Parkinson's disease

    Fu-Ming Zhou

    26. Disruptions of frontostriatal language functions in Parkinson's Disease

    Adolfo M. Garcia

    27. Synuclein and neuroinflammation in Parkinson's disease

    Luigi Bubacco

    28. Tau and its interactions with other proteins in neurodegenerative disease

    Paul R. Fisher

    29. Dopamine and the renin-angiotensin system in neuronal tissues Parkinson's Disease

    Jose Luis Labandeira Garcia

    30. Restoring dopamine levels in Parkinson’s disease

    Henning Ulrich and Ágatha Oliveira-Giacomelli

    III. Behaviour and Psychopathology

    31. Motivation and motivational aspects of Parkinson's disease

    Abdeslam Chagraoui

    32. Linking anxiety, cognitive and sensory deficits to gait and balance in Parkinson’s disease

    Quincy J. Almeida

    33. Interlinking motor program of gait and bradykinesia in Parkinson's disease

    Tateo Warabi

    34. Olfactory features in Parkinson's disease

    Marcelo M. S. Lima

    IV. Diet And Nutrition

    35. Interlinking dementia in Parkinson's disease: and nutritional correlates of body composition

    Arthur Oscar Schelp

    36. The role of the gut microbiota in Parkinson's disease

    Ryan Anderton and Jade Kenna

    37. Swallowing defects in Parkinson’s disease

    Maira Rozenfeld Olchik

    38. The Mini Nutritional Assessment (MNA ) and applications to Parkinson’s disease

    Svetlana Tomic

    39. Bacopa monnieri extract and Parkinson’s disease

    Ravikumar Hosamani

    V. Models, Modelling and Resources

    40. 6-hydroxydopamine-induced model of Parkinson’s disease

    Katarzyna Kaczynska

    41. Knockdown transgenic Drosophila and Parkinson’s disease

    Carlos Velez-Pardo and Marlene Jimenez-Del-Rio

    42. Evidence for neuroprotection in animal models of Parkinson’s disease

    John Mitrofanis

    43. Modelling with the A53T alpha-synuclein model of Parkinson’s disease

    CW Ip

    44. Linking the leucine-rich repeat kinase 2 (LRRK2) gene, animals models and Parkinson’s disease

    Yulan Xiong


    Rajkumar Rajendram

Product details

  • No. of pages: 1612
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: September 23, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128159590
  • Hardcover ISBN: 9780128159583

About the Editors

Colin Martin

: Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing University of Suffolk, Ipswich, UK

Victor Preedy

Professor Preedy has been elected as a Fellow to the following Royal Societies: The Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, the Royal Society of Chemistry, and the Royal Society of Medicine. He was founding Director of the Genomics Centre at King’s College London and held the post from 2006 to 2020. He is a leading expert on the science of health and has a long-standing interest in disease processes, biomarkers, and tissue pathology. He has lectured nationally and internationally. Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor in the Department of Clinical Biochemistry at King’s College Hospital, London, UK Emeritus Professor in Faculty of Life Sciences and Medicine at King’s College London, UK Visiting Professor at the University of Hull, UK

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