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The Exposome: A New Paradigm for the Environment and Health, Second Edition, is a thoroughly expanded and updated edition of The Exposome: A Primer, the first book dedicated to the topic. This new release outlines the purpose and scope of this emerging field of study, its practical applications, and how it complements a broad range of disciplines. The book contains sections on -omics-based technologies, newer detection methods, managing and integrating exposome data (including maps, models, computation and systems biology), and more. Both students and scientists in toxicology, environmental health, epidemiology and public health will benefit from this rigorous, yet readable, overview.
This updated edition includes a more in-depth examination of the exposome, including full references, further reading and thought questions.
- Addresses an emerging field that connects with other exciting disciplines
- Written by a single author who is a leader in the field
- Includes new content that widely expands on the first edition
Graduate students and professional scientists interested in environmental mediators of disease. These include graduate students and scientists from such disciplines as toxicology, environmental health sciences, epidemiology, genetics, public health, medicine, and nursing as well as advanced undergraduates in biology and health.
1. Introduction: The Need of the Exposome
2. Genes, Genomes and Genomics: A Historical Perspective of Genomics up to Modern Day Advances
3. What is Nurture?
4. The Environment: The Good, the Bad and the Ugly
5. Collecting Exposure Information, Signals, Noise and Noise-Measure
6. Technological Issues
7. Exposome and Pathways
8. Big Data for the Exposome
9. The Exposome in the Community
10. The Exposome in Large Human Studies
11. The Exposome in the Future
- No. of pages:
- © Academic Press 2020
- 2nd June 2020
- Academic Press
- eBook ISBN:
- Paperback ISBN:
Gary W. Miller, PhD is the Vice Dean for Research Strategy and Innovation and Professor of Environmental Health Sciences at the Mailman School of Public Health at Columbia University. He was founding director of the HERCULES Exposome Research Center at Emory University, the first exposome-based center in the U.S. In addition to his work on the exposome, his research interests include the role of environmental factors in neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease, and the regulation of dopamine signaling in the brain. He served as Editor-in-Chief of Toxicological Sciences, the official journal of the Society of Toxicology, from 2013-2019.
Vice Dean for Research Strategy and Innovation, Professor of Environmental Health Sciences, Mailman School of Public Health, Columbia University, USA
"In chapter 5, Dean Miller provides a comparison of "-omes and citations" from 2013 to 2019. Given the genealogy of the genome (first noted in 1920), the proteome (1994), the transcriptome (1997), epigenomics (1950s), toxigenomics (1999), and the exposome (2005), the latter is certainly the newcomer, making its 10,000-fold citation expansion (2005-2015) astonishing. Exposome-related research and applications are not only relevant to environmental health sciences but factors that will define environmental health sciences and likely public health as well." --Doody
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