Purification of Laboratory Chemicals

7th Edition

Authors: W.L.F. Armarego Christina Chai
Paperback ISBN: 9780123821614
eBook ISBN: 9780123821621
Imprint: Butterworth-Heinemann
Published Date: 2nd November 2012
Page Count: 1024
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A best seller since 1966, Purification of Laboratory Chemicals keeps engineers, scientists, chemists, biochemists and students up to date with the purification of the chemical reagents with which they work, the processes for their purification, and guides readers on critical safety and hazards for the safe handling of chemicals and processes.

The Seventh Edition is fully updated and provides expanded coverage of the latest commercially available chemical products and processing techniques, safety and hazards: over 200 pages of coverage of new commercially available chemicals since the previous edition.

Key Features

  • The only comprehensive chemical purification reference, a market leader since 1966, Amarego delivers essential information for research and industrial chemists, pharmacists and engineers: '... (it) will be the most commonly used reference book in any chemical or biochemical laboratory' (MDPI Journal)
  • An essential lab practice and proceedures manual. Improves efficiency, results and safety by providing critical information for day-to-day lab and processing work. Improved, clear organization and new indexing delivers accurate, reliable information on processes and techniques of purification along with detailed physical properties
  • The Sixth Edition has been reorganised and is fully indexed by CAS Registry Numbers; compounds are now grouped to make navigation easier; literature references for all substances and techniques have been added; ambiguous alternate names and cross references removed; new chemical products and processing techniques are covered; hazards and safety remain central to the book


Chemical Engineers, Chemists, Biochemists and Pharmaceutical Engineers who process and purify commercial chemicals in industry; university and commercial research laboratories

Table of Contents


Preface to the Seventh Edition

Preface to the First Edition

Preface to the Second Edition

Preface to the Third Edition

Preface to the Fourth Edition

Preface to the Fifth Edition

Preface to the Sixth Edition

How This Book Should Be Used

About the Authors

Chapter 1. Common Physical Techniques Used in Purification


The Question of Purity

Sources of Impurities

Practices to Avoid Impurities

Safety Precautions Associated with the Purification of Laboratory Chemicals

Some Hazards of Chemical Manipulation in Purification and Recovery of Residues

Safety Disclaimer

Methods of Purification of Reagents and Solvents

Solvent Extraction and Distribution







Properties Useful in Purification

Miscellaneous Techniques

Chemical and Biochemical Sources

Useful Websites


Chapter 2. Chemical Methods Used in Purification

General Remarks

Removal of Traces of Metals from Reagents

Use of Metal Hydrides

Sodium Borohydride

Purification Via Derivatives

General Methods for the Purification of Classes of Compounds

General Procedures for the Purification of Some Classes of Organic Compounds


Chapter 3. The Future of Purification


Atom Economy


Microwave Technologies

Flow Chemistry

Solid Phase Synthesis

Alternative Solvents


Chapter 4. Purification of Organic Chemicals


Aliphatic Compounds

Alicyclic Compounds

Aromatic Compounds

Heterocyclic Compounds

Miscellaneous as, B, P, Si, S, Se and Te


No. of pages:
© Butterworth-Heinemann 2013
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About the Author

W.L.F. Armarego

Wilfred L. F. Armarego graduated BSc (Hons) in 1953 and PhD from the University of London in 1956 and came to Australia in that year. After two years at the Central Research Laboratories (ICIANZ) in Melbourne, where he worked on plant growth substances, and one year on potentially carcinogenic polycyclic aromatic hydrocarbons at the University of Melbourne as Senior Demonstrator in Organic Chemistry, he joined the Department of Medical Chemistry as a Research Fellow in 1960. He became a Fellow in 1963 and was awarded a DSc degree (London) in 1968. He was promoted to Senior Fellow in 1967 and began research work on the biochemistry and molecular biology of pteridine-requiring enzymes related to the inherited metabolic disease phenylketonuria and its variants. He was head of the Protein Biochemistry Group and Pteridine Biochemistry Laboratory until his retirement in 1996. He is now a visiting fellow at the John Curtin School of Medical Research, and member of the editorial boards of ‘Medicinal Research Reviews’ and ‘Pteridines’ journals.

Affiliations and Expertise

Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia

Christina Chai

Affiliations and Expertise

Institute of Chemical and Engineering Sciences, Singapore


"This magnum opus is packed with carefully researched, up-to-date facts and figures. To the best of this author’s knowledge, it has no single equal…This book’s strengths are its choice of topics, the breadth and depth of information, its organization and easy access to information, and extensive current literature references…Summing up: Highly recommended." --CHOICE, August 2013

"This monograph remains the bible for practising chemists... (It) will be the most commonly used reference book in any chemical or biochemical laboratory." --MDPI