Progress in Medicinal Chemistry

Progress in Medicinal Chemistry

1st Edition - April 9, 2018

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  • Editors: David R. Witty, Brian Cox
  • Hardcover ISBN: 9780128152133
  • eBook ISBN: 9780444641441

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Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

Key Features

  • Provides extended, timely reviews of topics in medicinal chemistry
  • Contains targets and technologies relevant to the discovery of tomorrow’s drugs
  • Presents analyses of successful drug discovery programs


Everyone interested in the strategy and practice of the preclinical phases of the creation of new medicines. Those wishing to understand the drivers of drug design or expand their knowledge of therapeutic target classes

Table of Contents

  • 1. Discovery and Development of Calcimimetic and Calcilytic Compounds
    Edward F. Nemeth, Bradford C. Van Wagenen and Manuel F. Balandrin
    2. VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine)
    Nicole D. Harriott, John P. Williams, Evan B. Smith, Haig P. Bozigian and Dimitri E. Grigoriadis
    3. Current Trends in Macrocyclic Drug Discovery and Beyond-Ro5
    Sulejman Alihodzic, Mirjana Bukvic, Ivaylo J. Elenkov, Antun Hutinec, Sanja Koštrun, Dijana Pesic, Gordon Saxty, Linda Tomaškovic and Dinko Ziher
    4. Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR
    Phil R. Kym, Xueqing Wang, Mathieu Pizzonero and Steven E. Van der Plas
    5. Big Data in Drug Discovery
    Nathan Brown, Jean Cambruzzi, Peter J. Cox, Mark Davies, James Dunbar, Dean Plumbley, Matthew A. Sellwood, Aaron Sim, Bryn I. Williams-Jones, Magdalena Zwierzyna and David W. Sheppard

Product details

  • No. of pages: 366
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: April 9, 2018
  • Imprint: Elsevier
  • Hardcover ISBN: 9780128152133
  • eBook ISBN: 9780444641441

About the Serial Editors

David R. Witty

David R. Witty
Dr David Witty has more than 20 years experience in the pharmaceutical industry as a medicinal chemist and project leader working principally in areas of anti-infectives, metabolic diseases, cognition and pain, delivering clinical candidates for several conditions. He led IT Strategy within the Neurology division of GSK, developing and deploying the first Electronic Notebooks for drug discovery to sites in the UK and Singapore. He has contributed more than 90 scientific papers, reviews, patents and books on medicinal and synthetic chemistry.

In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. David presently leads their discovery programme and manages scientific operations within the business.

David is chairman of the Fine Chemicals Group of the Society of Chemical Industry, with responsibility for the delivery of conferences, seminars and training courses for chemists throughout the UK and Europe, and advising parliamentary bodies on matters of relevance to the UK chemical industry.

Since 2008 David has been a STEM ambassador for SETPOINT, introducing school students at both primary and secondary level to the excitement and possibilities of pursuing scientific careers, through workshops, lectures and competitions.

Affiliations and Expertise

WITNET LTD, Cambridge, UK

Brian Cox

Professor Brian Cox is at University of Sussex, Brighton, UK

Affiliations and Expertise

Professor, University of Sussex, Brighton, UK

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