Primer to the Immune Response
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Primer to the Immune Response

2nd Edition - December 23, 2013

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  • Authors: Tak Mak, Mary Saunders, Bradley Jett
  • Paperback ISBN: 9780123852458
  • eBook ISBN: 9780123854612

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Description

Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject’s fascinating appeal. The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.

Key Features

  • Complete yet concise coverage of the basic and clinical principles of immunology
  • Engaging conversational writing style that is to the point and very readable
  • Over 200 clear, elegant color illustrations
  • Comprehensive glossary and list of abbreviations

Readership

Undergraduate medical students and graduate students taking the following courses: Introduction to Immunology, Immunology, Clinical Immunology, Medical Immunology, Medical Microbiology, Microbiology and Immunology, and Immunology and Disease

Table of Contents

  • Abbreviations

    Online Study Guide

    Preface

    The Academic Cell Approach

    Introduction to the Online Study Guide

    Biographies: Authors

    Contributors

    Acknowledgments

    Part I: Basic Immunology

    Chapter 1. Introduction to the Immune Response

    Abstract

    A Historical Orientation

    B The Nature of the Immune Response

    C Types of Immune Responses: Innate and Adaptive

    D Interplay between the Innate and Adaptive Responses

    E Clinical Immunology

    Would You Like To Read More?

    Chapter 2. Components of the Immune System

    Abstract

    A Cells of the Immune System

    B How Leukocytes Communicate

    C Lymphoid Tissues

    D Cellular Movement in the Immune System

    Would You Like To Read More?

    Chapter 3. Innate Immunity

    Abstract

    A Non-Inducible Innate Mechanisms

    B Inducible Innate Mechanisms

    Would You Like To Read More?

    Chapter 4. The B Cell Receptor: Proteins and Genes

    Abstract

    A Immunoglobulin Proteins

    B Immunoglobulin Genes

    C Antibody–Antigen Interaction

    Would You Like To Read More?

    Chapter 5. B Cell Development, Activation and Effector Functions

    Abstract

    A B Cell Development: Maturation Phase

    B B Cell Development: Differentiation Phase

    C Effector Functions of Antibodies

    D Immunoglobulin Isotypes in Biological Context

    E Sources of Laboratory and Clinical Antibodies

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    Chapter 6. The Major Histocompatibility Complex

    Abstract

    A Overview of the Major Histocompatibility Complex

    B MHC Class I and Class II Proteins

    C MHC Class I and Class II Genes

    D Physiology of the MHC

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    Chapter 7. Antigen Processing and Presentation

    Abstract

    A Overview of Antigen Processing and Presentation

    B Nature of Cells That Can Activate T Cells

    C Major Antigen Processing and Presentation Pathways

    D Other Methods of Antigen Presentation

    Would You Like To Read More?

    Chapter 8. The T Cell Receptor: Proteins and Genes

    Abstract

    A TCR Proteins and Associated Molecules

    B TCR Genes

    C TCR–Antigen Interaction

    Would You Like To Read More?

    Chapter 9. T Cell Development, Activation and Effector Functions

    Abstract

    A T Cell Development

    B T Cell Activation

    C Th Cell Differentiation and Effector Function

    D Tc Cell Differentiation and Effector Function

    E Termination of Effector T Cell Responses

    F Memory T Cells

    Would You Like To Read More?

    Chapter 10. Regulation of Immune Responses in the Periphery

    Abstract

    A Lymphocyte Tolerance in the Periphery

    B Regulation of Lymphocyte Responses in the Periphery

    C Special Tolerance Situations

    D Experimental Tolerance

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    Chapter 11. NK, γδ T and NKT Cells

    Abstract

    A Natural Killer (NK) Cells

    B γδ T Cells

    C NKT Cells

    Would You Like To Read More?

    Chapter 12. Mucosal and Cutaneous Immunity

    Abstract

    A Mucosal Immunity

    B Cutaneous Immunity

    Would You Like To Read More?

    Part II: Clinical Immunology

    Chapter 13. Immunity to Infection

    Abstract

    A General Features of Host–Pathogen Encounters

    B Immunity to Extracellular Bacteria

    C Immunity to Intracellular Bacteria

    D Immunity to Viruses

    E Immunity to Parasites

    F Immunity to Fungi

    G Prions

    Would You Like To Read More?

    Chapter 14. Vaccination

    Abstract

    A Introduction

    B Vaccine Design

    C Types of Vaccines

    D Adjuvants and Delivery Vehicles

    E Prophylactic Vaccines

    F Vaccines in the Real World

    G Future Directions

    Would You Like To Read More?

    Chapter 15. Immunodeficiency

    Abstract

    A Primary Immunodeficiency

    B HIV Infection and Acquired Immunodeficiency Syndrome (AIDS)

    Would You Like To Read More?

    Chapter 16. Tumor Immunology

    Abstract

    A Tumor Biology

    B Tumor Antigens

    C Immune System Function in the Tumor Microenvironment

    D Conventional Cancer Therapy

    E Immunotherapy

    Would You Like To Read More?

    Chapter 17. Transplantation

    Abstract

    A The Nature of Transplantation

    B The Molecular Basis of Graft Rejection

    C Solid Organ Transplantation

    D Minimizing Graft Rejection

    E Hematopoietic Stem Cell Transplantation

    F Blood Transfusions

    Would You Like To Read More?

    Chapter 18. Immune Hypersensitivity

    Abstract

    A Type I Hypersensitivity: IgE-Mediated or Immediate

    B Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxic Hypersensitivity

    C Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity

    D Type IV Hypersensitivity: Delayed Type or Cell-Mediated Hypersensitivity

    Would You Like To Read More?

    Chapter 19. Autoimmune Diseases

    Abstract

    A What is an Autoimmune Disease?

    B Mechanisms Underlying Autoimmune Diseases

    C Examples of Autoimmune Diseases

    D Determinants of Autoimmune Diseases

    E Therapy of Autoimmune Diseases

    F Autoinflammatory Disorders

    Would You Like To Read More?

    Chapter 20. Hematopoietic Cancers

    Abstract

    A Overview of the Biology and Treatment of Hematopoietic Cancers

    B Leukemias

    C Myelomas

    D Lymphomas

    Would You Like To Read More?

    Appendix A. Selected Landmark Discoveries in Immunology

    Would You Like To Read More?

    Appendix B. Nobel Prizes Awarded for Work in Immunology

    Would You Like To Read More?

    Appendix C. Comparative Immunology

    Would You Like To Read More?

    Appendix D. Selected CD Markers

    Appendix E. Cytokines, Chemokines and Receptors

    Appendix F. Selected Immunological Techniques

    I Experimental Techniques Using Antibodies

    II The Polymerase Chain Reaction

    III HLA Typing Techniques

    IV Laboratory Mouse Strains

    Would You Like To Read More?

    Glossary

    Index

Product details

  • No. of pages: 702
  • Language: English
  • Copyright: © Academic Cell 2014
  • Published: December 23, 2013
  • Imprint: Academic Cell
  • Paperback ISBN: 9780123852458
  • eBook ISBN: 9780123854612

About the Authors

Tak Mak

Tak Mak
Tak W. Mak is the Director of the Campbell Family Institute for Breast Cancer Research in the Princess Margaret Hospital, Toronto, Canada, and a University Professor in the Departments of Medical Biophysics and Immunology, University of Toronto. He was trained at the University of Wisconsin in Madison, the University of Alberta, and the Ontario Cancer Institute. He gained worldwide prominence in 1984 as the leader of the team that first cloned the genes of the human T cell antigen receptor. His group went on to create a series of genetically altered mice that have proved critical to understanding intracellular programs governing the development and function of the immune system, and to dissecting signal transduction cascades in various cell survival and apoptotic pathways. His current research remains centered on mechanisms of immune recognition/regulation, malignant cell survival/death, inflammation in autoimmunity and cancer, and metabolic adaptation in tumor cells. Dr. Mak has published over 700 papers and holds many patents. He has been granted honorary doctoral degrees from universities in North America and Europe, is an Officer of the Orders of Canada and Ontario, and has been elected a Foreign Associate of the National Academy of Sciences (U.S.), a Fellow of the Royal Society of London (U.K.), and a Fellow of the AACR Academy. Dr. Mak has won international recognition as the recipient of the Emil von Behring Prize, the King Faisal International Prize for Medicine, the Gairdner Foundation International Award, the Sloan Prize of the General Motors Cancer Foundation, the Novartis Prize in Immunology, the Robert Noble Prize, the Killam Prize, the Stacie Prize, the McLaughlin Medal, and the Paul Ehrlich and Ludwig Darmstaedter Prize.

Affiliations and Expertise

The Campbell Family Institute for Breast Cancer Research, Ontario, Canada

Mary Saunders

Mary Saunders
Mary E. Saunders holds the position of Scientific Editor for the Campbell Family Institute for Breast Cancer Research, Toronto, Canada. She completed her B.Sc. degree in Genetics at the University of Guelph, Ontario, and received her Ph.D. in Medical Biophysics at the University of Toronto. Dr. Saunders works with Dr. Mak and members of his laboratory on the writing and editing of scientific papers for peer-reviewed journals as well as on various grant applications and book projects. She takes pride and pleasure in producing concise, clear, highly readable text and making complex scientific processes readily understandable.

Affiliations and Expertise

The Campbell Family Institute for Breast Cancer Research, Ontario, Canada

Bradley Jett

Bradley Jett
Bradley D. Jett is the James Hurley Professor of Biology at Oklahoma Baptist University (OBU) in Shawnee, Oklahoma, USA. He completed his B.S. degree in Biology from OBU, followed by his Ph.D. in Microbiology and Immunology from the University of Oklahoma College of Medicine. After a postdoctoral fellowship at Washington University in St. Louis, Missouri, he joined the faculty at the University of Oklahoma College of Medicine. His research interests are primarily focused on host-parasite relationships. Much of his published work relates to the virulence factors of Gram-positive bacteria such as Enterococcus, Staphylococcus and Bacillus, as well as the host immunological responses to these infections. In his current full-time, undergraduate teaching position at his alma mater, he has been awarded Oklahoma Baptist University’s Promising Teacher Award and the Distinguished Teaching Award.

Affiliations and Expertise

Oklahoma Baptist University, Oklahoma, USA

Ratings and Reviews

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  • Roger C. Sun Feb 25 2018

    Haven`t you read it yet?

    We have been using this book as the primary source for discussions in graduate courses. It is a must read book for those who initiate in the field of immunology and a very complete reference book for those researchers whose questions touch the immune system or involve integrative experimental or clinical medicine. Divided in two large sections, one on the foundations of immunology, the other on aspects of clinical immunology, the text brings up-to-date information written in a very direct and unambiguous way. Questions at the end of each chapter are very useful for discussions in group and to promote team-based learning. It is one of those "must have" books that are likely to be found in any biomedical laboratory book shelf.

  • Zoie F. Sun Feb 25 2018

    Best Immunology textbook

    I have gone through many books on immunology, but I found this book the best. It covers all the concepts, answers all the question one can have in his mind while studying Immunology. Well written and well explained. I have only one suggestion to the respected authors and the publishers: If possible change the title of the book. The title should be as simple as the way you have written the book. Keep it something like Immunology or the Immune system. I am suggesting this because when I first came to know about the book, reading the title made me feel that book must be complicated and for very advanced studies. I ignored the book for a long time only for this one reason. But once I read this book, I came to know that this book is the best available book to study immunology for graduate, postgraduate students. Thank you.