Description

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

Key Features

  • Multi-contributed book and chapters are written by contributors who are experts in their field
  • Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be
  • Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications
  • Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
  • A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting

Readership

This book is intended for scientists and clinicians interested in pharmacogenomics implementation in academic, research, medical and pharmaceutical industry settings. Relevant fields include pharmacology, pharmaceutical sciences, genetics, molecular biology and medicine. This book may also be used as a recommended textbook for pharmacy students and graduate-level students in health and pharmaceutical science programs. 

Table of Contents

Dedication

List of Contributors

Preface

Chapter 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications

Objectives

Introduction

Cytochrome P-450 Enzymes

Non-CYP-450 Drug Metabolizing Enzymes

Polymorphisms in Drug Transporter Genes

Drug Target Genes

Conclusion

Questions for Discussion

References

Chapter 2. Translating Pharmacogenomic Research to Therapeutic Potentials

Objectives

Introduction

Implementation of Biomarkers in Clinical Practice

Incorporating Pharmacogenomics into Drug Development

Conclusion

Questions for Discussion

References

Chapter 3. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics

Objectives

Introduction

The Role of the National Institutes of Health

The Role of the Food and Drug Administration and Other International Government Agencies

Activities of Non-U.S. Agencies

Conclusion

Questions for Discussion

References

Chapter 4. Pharmacogenomics in Cancer Therapeutics

Objectives

Introduction

Role of Oncology Biomarkers

Concepts in Targeted Cancer Therapy

Oncology in the Postgenomic Era

Challenges in Drug Development and Cancer Trials

Seeking Pharmacogenomic Value

Questions for Discussion

References

Chapter 4A. A Look to the Future: Cancer Epigenetics

Learning Objectives

Introduction

Histone Modification

DNA Methylation

Noncoding RNA (ncRNA)

Conclusion

Questions for Discussion

References

Chapter 5. Pharmacogenetics in Cardiovascular Diseases

Objectives

Introduction

Pharmacogenomics of Antiplatelet Agents

Warfarin Pharmacogenomics

Other

Details

No. of pages:
510
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780123919182
Electronic ISBN:
9780123983039

About the authors

Yui-Wing Francis Lam

Affiliations and Expertise

PharmD, Professor of Pharmacology, Department of Pharmacology and Associate Professor, Department of Medicine, The University of Texas Health Science Center at San Antonio

Larisa Cavallari

Affiliations and Expertise

PharmD, Associate Professor, Department of Pharmacy Practice, University of Illinois at Chicago

Reviews

"...a practical and indispensable resource on both the opportunities and challenges that allows readers to reflect on the future direction of pharmacogenomics while applying these observations to their own work or research."--Anticancer Research, February 2015

"Lam and Cavallari bring together pharmacy and other specialists from North America, Europe, and Asia for 13 chapters aimed at scientists, clinicians, and students in health and pharmaceutical sciences. The chapters consider the translation of pharmacogenomic findings into therapeutic applications from academic, regulatory, pharmaceutical, clinical, socioethical, and economic perspectives."--Reference and Research Book News, August 2013
"This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine."--Doody.com, August 2, 2013