Key Features

  • Understand the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.
  • Visually grasp and retain difficult concepts easily thanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases.
  • Put concepts into practice. "Critical Thinking Boxes" and 25 online cases encourage you to "think immunologically" while anchoring your understanding of immunology through clinical application.
  • Gauge your mastery of the material and build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams.
  • Access the full contents online at www.studentconsult.com where you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more!

Table of Contents

Preface vii

List of Contributors ix

SECTION 1

Components of the Immune System 1

1 Introduction to the Immune System 3

David Male

2 Cells, Tissues, and Organs of the

Immune System 17

Peter M Lydyard and Nino Porakishvili

3 Antibodies 51

Roy Jefferis

4 Complement 71

B Paul Morgan

5 T Cell Receptors and MHC Molecules 89

David B Roth

SECTION 2

Modes of Immune Response 107

6 Mechanisms of Innate Immunity 109

David Male

7 Mononuclear Phagocytes in Immune

Defense 125

Luisa Martinez-Pomares and

Siamon Gordon

8 Antigen Presentation 143

David Male

9 Cell Cooperation in the Antibody

Response 157

Joseph C Marini and Kalpit A Vora

10 Cell-mediated Cytotoxicity 171

Victoria Male

11 Regulation of the Immune Response 183

David Bending

12 Immune Responses in Tissues 199

David Male

SECTION 3

Defense Against Infectious Agents 209

13 Immunity to Viruses 211

Persephone Borrow and Anthony A Nash

14 Immunity to Bacteria and Fungi 223

Gregory J Bancroft

15 Immunity to Protozoa and Worms 243

Richard J Pleass

16 Primary Immunodeficiencies 263

Luigi D Notarangelo

17 AIDS, Secondary Immunodeficiency

and Immunosuppression 277

Dean H Kedes and Lisa A Nichols

18 Vaccination 289

Colin Casimir

SECTION 4

Immune Responses Against Tissues 305

19 Immunological Tolerance 307

Thomas Kamradt

20 Autoimmunity and Autoimmune

Disease 323

James E Peters and David A Isenberg

21 Transplantation and Rejection 341

Andrew J T George

22 Immunity to Cancers 355

Pramod K Srivastava

V

SECTION 5

Hypersensitivity 369

23 Imm

Details

No. of pages:
482
Language:
English
Copyright:
© 2013
Published:
Imprint:
Saunders
Electronic ISBN:
9780723436829
Electronic ISBN:
9780702050282
Electronic ISBN:
9780702056666
Electronic ISBN:
9780702062407
Print ISBN:
9780323080583
Print ISBN:
9780702045486