Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease

Emerging Roles of Nutraceuticals and Functional Foods in Immune Support

1st Edition - August 31, 2017

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  • Editors: Shampa Chatterjee, Wolfgang Jungraithmayr, Debasis Bagchi
  • Hardcover ISBN: 9780128054178
  • eBook ISBN: 9780128054024

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Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field  and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here.

Key Features

  • Conceptualizes the key features in natural products which can boost immune function and immune health
  • Explains the intricate mechanistic aspects and balance behind immune health
  • Presents the pathophysiology of several diseases associated with immune system disruption


Product developers in nutraceutical, supplement, functional food, and health food companies. Researchers studying immune health either in academia, or in the nutraceutical or functional food industries

Table of Contents

  • Section I: Innate and Adaptive Immune Systems: Components and Regulation
    1. Innate and Adaptive Immunity: Barriers and Receptor Based Recognition
    2. Innate Immunity at Birth: Implications for Inflammation and Infection in Newborns
    3. Redox Signaling and Onset of the Inflammatory Cascade

    Section II: Reactive Oxygen Species, Oxidative Stress and Immune Cell Activation
    4. Reactive Oxygen Species, Oxidative Damage and Cell Death
    5. Mitochondrial ROS and T Cell Activation
    6. Oxidants and Inflammation: Endothelial Targeting Of Antioxidants to Combat Disease
    7. Oxidative Signaling In Chronic Obstructive Airway Diseases

    Section III: Inflammatory Systems: Mechanistic Pathways Of Stimulation and Suppression
    8. Immune Responses in the Upper Respiratory Tract in Health and Disease
    9. The Biological Role of NADPH Oxidases in Pulmonary Ischemia-Reperfusion Injury in Pulmonary Inflammation
    10. Receptor Blockade of CD26/DPP4 as a Therapeutic Strategy Against I/R Injury and Lymphocytic Inflammation And Its Clinical Implications
    11. DPPIV/CD26 as A Target in Anti-Inflammatory Therapy
    12. Redox Sensitive Transcription via Nrf2-Keap1 in Suppression of Inflammation

    Section IV: Immunity and Inflammation: Common Threads Of Multifactorial Diseases
    13. Monogenic Defects of Toll-Loke receptor Signaling and Primary Immunodeficiency
    14. PPAthogen - and Microbial- Associated Molecular Patterns (PAMPs/MAMPs) in the Innate Immune Response in Crohn's Disease
    15. Inflammation and Calcification in the Vascular Tree; Insights into Atherosclerosis
    16. From Inflammation to Cancer: Opportunites for Chemoprevention via Dietary Intervention
    17. Inflammation in Bullous Pemphigoid, a Skin Auto-Immune Disease
    18. Inflammation in Systemic Immune Diseases: Role of TLR9 Signaling and the Resultant Oxidative Stress in Pathology of Lupus

    Section V: Nutraceuticals in Boosting Immune Support and as Therapeutics for Inflammatory Diseases
    19. Anti-inflammatory and Anti-microbial Properties of Achillea millefolium in Acne Treatment
    20. Lactobacillus Gasseri Potentiates Immune Response Against Influenza Virus Infection
    21. Micronutrients in Skin Immunity and Associated Diseases
    22. Mycobiome and Gut Inflammation: Implications in Inflammatory Bowel Disease
    23. Flavonoids in Treating Psoriasis
    24. Probiotics and Anti-Inflammatory Processes in HIV Infected: From Benchside Research to Bedside
    25. Chronic Inflammation in Asthma: Anti-Malarial Drug Artesunate as a Therapeutic Agent
    26. Nutrition as a Tool to Reverse Immunosenescence?

    Section VI: New Perspectives and Future Directions
    27. Therapeutic Interventions to Block Oxidative Stress-Associated Pathologies
    28. Phytochemicals as Anti-Inflammatory Nutraceuticals and Phytophamaceuticals
    29. Fermented Milk in Protection Against Inflammatory Mechanisms In Obesity
    30. Prebiotics and Probiotics in Altering Microbiota: Implications in Colorectal Cancer
    31. Naturopathy and Lifestyle Interventions in Boosting Immune Responses in HIV Positive Population
    32. Eating Habits and Fighting Disease: Nutraceuticals and Functional Foods at the Intersection of Immune Health and Inflammatory Responses

Product details

  • No. of pages: 476
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: August 31, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128054178
  • eBook ISBN: 9780128054024

About the Editors

Shampa Chatterjee

Dr. Shampa Chatterjee received her PhD in Chemistry from the Indian Institute of Technology (Bombay) in 1997. Her research interests are in the field of reactive oxygen species (ROS) and redox biology as it relates to inflammation. Her lab studies the effect of ROS generated by the vascular wall in onset of inflammation. Toward this, work from her group shows that signals emanating from the wall of blood vessels are the earliest stimuli for the onset and amplification of inflammation. The topics addressed in this book are thus central to her research where she tries to unravel the balance between host defense and inflammation induced damage.

Currently, Dr. Chatterjee serves on the Editorial Board of several journals in the field of pulmonary physiology (American Journal of Physiology: Lung Cellular and Molecular Physiology, Pulmonary Circulation and Jacobs Journal of Physiology). She has published more than 50 papers in peer reviewed journals. She has also received numerous awards such as the Carolin Tum Suden young Investigator Award, and the Hermann Rahn award for Excellence if Pulmonary Physiology in 2015.

Affiliations and Expertise

University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Wolfgang Jungraithmayr

Wolfgang Jungraithmayr MD, PhD is a transplant surgeon and immunologist with a research interest in the field of transplant and tumor immunology. His lab has unraveled some of the signaling events that follow the transplant procedure and that lead to allograft rejection post lung transplant. He is professor of thoracic surgery at the University of Zurich, Switzerland, and the Medical University Brandenburg, Germany. Wolfgang Jungraithmayr published more than 70 original articles and received several awards, among them the Grillo Award of the European Society of Thoracic Surgeons

Affiliations and Expertise

University Hospital Zurich, Zurich, Switzerland Medical University Brandenburg, Brandenburg, Germany

Debasis Bagchi

Debasis Bagchi
Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Affiliations and Expertise

Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USA

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