This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

Table of Contents


Chapter One. Biochemistry and Function of RNA Exosomes

1. Introduction

2. Cellular Functions of the Exosome

3. Composition of Exosomes and Their Related Complexes

4. Exosome Cofactors

5. Concluding Remarks


Chapter Two. Plant Exosomes and Cofactors

1. Introduction

2. Composition of the Plant Exosome Core Complex

3. Exosome-Related Activities and Cofactors in Plants

4. Impact of Exosome-Mediated Degradation in Plants

5. Final Remarks


Chapter Three. Structure and Activities of the Eukaryotic RNA Exosome

1. Introduction

2. Global Architecture of the Eukaryotic Exosome Core

3. RNase PH-Like Domains Comprise a PH-Like Ring in Eukaryotic Exosomes

4. S1 and KH Domains Cap the PH-Like Ring

5. RRP44, a Hydrolytic Endoribonuclease and Processive Exoribonuclease

6. RRP44 and the 10-Component Exosome

7. RRP6, a Eukaryotic Exosome Subunit with Distributive Hydrolytic Activities

8. RRP44, RRP6, and the 11-Component Nuclear Exosome

9. Conclusions


Chapter Four. TRAMP Stimulation of Exosome

1. TRAMP Is a Cofactor of Nuclear Exosome

2. RNA Substrate Repertoire of TRAMP

3. TRAMP Biochemistry and Structure

4. TRAMP Complex in Activation of the Exosome

5. TRAMP Complexes in Different Organisms


Chapter Five. XRN1: A Major 5′ to 3′ Exoribonuclease in Eukaryotic Cells

1. Introduction

2. XRN1 in mRNA Decay

3. XRN1 in mRNA Quality Control

4. XRN1 in miRNA-Mediated Decay

5. XRN1 in siRNA-Mediated Decay

6. Localization of XRN1 in Cells

7. XRN1 in lncRNA Decay

8. XRN1 in tRNA Quality Control

9. XRN1 in rRNA and snoRNA Processing

10. Regulation of XRN1 Activity

11. Summary



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© 2012
Academic Press
Electronic ISBN:
Print ISBN:

About the serial-volume-editors

Fuyuhiko Tamanoi

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.