Cann's Principles of Molecular Virology

Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work. It discusses the interactions which control the structure of virus particles, the ways viruses infect cells, how viruses replicate themselves, and the consequences and pathogenesis of virus infection for host organisms. This fully updated edition also reflects advances made in the field and includes new content on phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses. With the addition of ancillary resources, Cann's Principles of Molecular Virology, Seventh Edition is an essential foundational reference for academics, graduate students, and advance undergraduates in virology, molecular biology, and microbiology as well as researchers entering virology, infectious disease, and immunology research.

• Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology
• Includes new concepts in this edition include coverage of emerging topics and new technologies in viral research like phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses
• Contains updated learning outcomes and further reading for each chapter
• Supported by online resources for students and instructors

Academics and graduate students in virology, molecular biology, and microbiology; Researchers entering virology, infectious disease, and immunology research

Chapter 1. Introduction

• Intended Learning Outcomes
• What Are Viruses?
• Are Viruses Alive?
• The History of Virology
• Living Host Systems
• Cell Culture Methods
• Serological/Immunological Methods
• Ultrastructural Studies
• Molecular Biology
• Further Reading

Chapter 2. Particles

• Intended Learning Outcomes
• The Function and Formation of Virus Particles
• Capsid Symmetry and Virus Architecture
• Helical Capsids
• Icosahedral (Isometric) Capsids
• Enveloped Viruses
• Complex Virus Structures
• Protein–Nucleic Acid Interactions and Genome Packaging
• Virus Receptors: Recognition and Binding
• Other Interactions of the Virus Capsid with the Host Cell
• Summary
• Further Reading

Chapter 3. Genomes

• Intended Learning Outcomes
• The Structure and Complexity of Virus Genomes
• Molecular Genetics
• Virus Genetics
• Virus Mutants
• Genetic Interactions between Viruses
• Nongenetic Interactions between Viruses
• Small DNA Genomes
• Large DNA Genomes
• Positive-Strand RNA Viruses
• Negative-Strand RNA Viruses
• Segmented and Multipartite Virus Genomes
• Reverse Transcription and Transposition
• The Virome—Evolution and Epidemiology
• Summary
• Further Reading

Chapter 4. Replication

• Intended Learning Outcomes
• Overview of Virus Replication
• Investigation of Virus Replication
• The Replication Cycle
• Summary
• Further Reading

Chapter 5. Expression

• Intended Learning Outcomes
• Expression of Genetic Information
• Control of Prokaryote Gene Expression
• Control of Expression in Bacteriophage λ
• Control of Eukaryote Gene Expression
• Genome Coding Strategies
• Transcriptional Control of Expression
• Posttranscriptional Control of Expression
• Summary
• Further Reading

Chapter 6. Infection

• Intended Learning Outcomes
• Virus Infections of Plants
• Immune Responses to Virus Infections in Animals
• Viruses and Apoptosis
• Interferons
• Evasion of Immune Responses by Viruses
• Virus–Host Interactions
• The Course of Virus Infections
• Prevention and Therapy of Virus Infection
• RNA Interference
• Viruses as Therapeutics
• Chemotherapy of Virus Infections
• Summary
• Further Reading

Chapter 7. Pathogenesis

• Intended Learning Outcomes
• Mechanisms of Cellular Injury
• Viruses and Immunodeficiency
• Virus-Related Diseases
• Bacteriophages and Human Disease
• Cell Transformation by Viruses
• Cell Transformation by Retroviruses
• Cell Transformation by DNA Viruses
• Viruses and Cancer
• New and Emergent Viruses
• Zoonoses
• Bioterrorism
• Summary
• Further Reading

Chapter 8. Subviral Agents: Genomes without Viruses, Viruses without Genomes

• Intended Learning Outcomes
• Satellites and Viroids
• Prions
• Pathology of Prion Diseases
• TSE in Animals
• Human TSEs
• Molecular Biology of Prions
• Summary
• Further Reading

Appendix 1. Glossary and Abbreviations

Appendix 2. Classification of Subcellular Infectious Agents

Appendix 3. The History of Virology Index