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Cann's Principles of Molecular Virology - 7th Edition - ISBN: 9780128227848

Cann's Principles of Molecular Virology

7th Edition

Author: Ed Rybicki
Paperback ISBN: 9780128227848
Imprint: Academic Press
Published Date: 1st June 2021
Page Count: 350
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Cann's Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work. It discusses the interactions which control the structure of virus particles, the ways viruses infect cells, how viruses replicate themselves, and the consequences and pathogenesis of virus infection for host organisms. This fully updated edition also reflects advances made in the field and includes new content on phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses. With the addition of ancillary resources, Cann's Principles of Molecular Virology, Seventh Edition is an essential foundational reference for academics, graduate students, and advance undergraduates in virology, molecular biology, and microbiology as well as researchers entering virology, infectious disease, and immunology research.

Key Features

  • Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology
  • Includes new concepts in this edition include coverage of emerging topics and new technologies in viral research like phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses
  • Contains updated learning outcomes and further reading for each chapter
  • Supported by online resources for students and instructors


Academics and graduate students in virology, molecular biology, and microbiology; Researchers entering virology, infectious disease, and immunology research

Table of Contents

Chapter 1. Introduction

  • Intended Learning Outcomes
  • What Are Viruses?
  • Are Viruses Alive?
  • The History of Virology
  • Living Host Systems
  • Cell Culture Methods
  • Serological/Immunological Methods
  • Ultrastructural Studies
  • Molecular Biology
  • Further Reading

Chapter 2. Particles

  • Intended Learning Outcomes
  • The Function and Formation of Virus Particles
  • Capsid Symmetry and Virus Architecture
  • Helical Capsids
  • Icosahedral (Isometric) Capsids
  • Enveloped Viruses
  • Complex Virus Structures
  • Protein–Nucleic Acid Interactions and Genome Packaging
  • Virus Receptors: Recognition and Binding
  • Other Interactions of the Virus Capsid with the Host Cell
  • Summary
  • Further Reading

Chapter 3. Genomes

  • Intended Learning Outcomes
  • The Structure and Complexity of Virus Genomes
  • Molecular Genetics
  • Virus Genetics
  • Virus Mutants
  • Genetic Interactions between Viruses
  • Nongenetic Interactions between Viruses
  • Small DNA Genomes
  • Large DNA Genomes
  • Positive-Strand RNA Viruses
  • Negative-Strand RNA Viruses
  • Segmented and Multipartite Virus Genomes
  • Reverse Transcription and Transposition
  • The Virome—Evolution and Epidemiology
  • Summary
  • Further Reading

Chapter 4. Replication

  • Intended Learning Outcomes
  • Overview of Virus Replication
  • Investigation of Virus Replication
  • The Replication Cycle
  • Summary
  • Further Reading

Chapter 5. Expression

  • Intended Learning Outcomes
  • Expression of Genetic Information
  • Control of Prokaryote Gene Expression
  • Control of Expression in Bacteriophage λ
  • Control of Eukaryote Gene Expression
  • Genome Coding Strategies
  • Transcriptional Control of Expression
  • Posttranscriptional Control of Expression
  • Summary
  • Further Reading

Chapter 6. Infection

  • Intended Learning Outcomes
  • Virus Infections of Plants
  • Immune Responses to Virus Infections in Animals
  • Viruses and Apoptosis
  • Interferons
  • Evasion of Immune Responses by Viruses
  • Virus–Host Interactions
  • The Course of Virus Infections
  • Prevention and Therapy of Virus Infection
  • RNA Interference
  • Viruses as Therapeutics
  • Chemotherapy of Virus Infections
  • Summary
  • Further Reading

Chapter 7. Pathogenesis

  • Intended Learning Outcomes
  • Mechanisms of Cellular Injury
  • Viruses and Immunodeficiency
  • Virus-Related Diseases
  • Bacteriophages and Human Disease
  • Cell Transformation by Viruses
  • Cell Transformation by Retroviruses
  • Cell Transformation by DNA Viruses
  • Viruses and Cancer
  • New and Emergent Viruses
  • Zoonoses
  • Bioterrorism
  • Summary
  • Further Reading

Chapter 8. Subviral Agents: Genomes without Viruses, Viruses without Genomes

  • Intended Learning Outcomes
  • Satellites and Viroids
  • Prions
  • Pathology of Prion Diseases
  • TSE in Animals
  • Human TSEs
  • Molecular Biology of Prions
  • Summary
  • Further Reading

Appendix 1. Glossary and Abbreviations

Appendix 2. Classification of Subcellular Infectious Agents

Appendix 3. The History of Virology Index


No. of pages:
© Academic Press 2021
1st June 2021
Academic Press
Paperback ISBN:

About the Author

Ed Rybicki

Dr. Edward Rybicki is a Professor in the Department of Molecular and Cell Biology and Biopharming Research Unit of the University of Cape Town, South Africa. His research interests focus around vaccinology, protein expression, marine viromics, and virus diversity. He has authored two books, co-authored over 120 articles and 19 reviews in peer-reviewed journals, about 20 book chapters, and a number of popular or opinion articles and conference reports. Dr. Rybicki is listed as an inventor on 17 patent families, with around 44 country patents published. He writes educational and study material for the Web like the Electronic Introduction to Molecular Virology as well as via the UCT Open Educational Resources page like the Manual of Online Molecular Biology Techniques, which is extensively used by researchers outside of UCT. He maintains a university-level Virology teaching resource called ViroBlogy, as well as a general public information site called Virology News, runs the International Society for Plant Molecular Farming site, co-curates an information page on aquatic viruses and another on virology and bioinformatics, and tweets on virology topics (and other things) under @edrybicki.

Affiliations and Expertise

Professor, Department of Molecular and Cell Biology and Biopharming Research Unit, University of Cape Town, South Africa

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