Handbook of the Biology of Aging book cover

Handbook of the Biology of Aging

The Handbook of the Biology of Aging, 7e, is 100% revised from the 6th edition.  Providing a comprehensive synthesis and review of the latest research findings in the biology of aging, it is intended as a summary for researchers, and is also suitable as a high level textbook for graduate and upper level undergraduate courses.  The 7th edition is organized into two main sections, first covering the basic aging processes and then the medical physiology of aging.  This puts less emphasis on research germane only to specific species and more emphasis on the mechanisms that affect aging across species, and what this means medically for the aging of humans.  This volume allows basic researchers to keep abreast of basic research outside their subdiscipline as well as recent clinical  findings, while allowing medical, behavioral, and social gerontologists to understand what basic scientists and clinicians are discovering.

Coverage of basic aging processes includes the effects of dietary restriction, somatotropic axis, free radicals, apoptosis, adipose tissue, stem cells, leukocyte telomere dynamics, genetics, sirtuins, inflammation, and protein homeostasis on aging.  Coverage of the medical physiology of aging includes several chapters on aging effects on the human brain including changes in brain myelination, cerebral microvasculature, and cerebral vascular dysfunction.    Additional chapters include research on aging pulmonary function, insulin secretion, thermoreception and thermoregulation, calorie restriction, frailty & mortality, and sex differences in longevity and aging.  This more clinically-oriented section advances our understanding  of what to expect, how to prevent, and how to treat common medical effects of aging.

The Handbook of the Biology of Aging, 7e is part of the Handbooks of Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 7th editions.

Researchers in gerontology, developmental psychology, social psychology, and sociology.

Paperback, 520 Pages

Published: November 2010

Imprint: Academic Press

ISBN: 978-0-12-378638-8


  • "This is an important and timely book on an extremely critical subject, and although its technical excellence and depth will challenge those without a formal background in molecular biology, the rewards I believe will be deeply commensurate with the effort… However, with that qualification in mind, the articles are uniformly of high quality and address critical issues in the science of aging-several, if not many, of these reviews are good enough to be considered benchmark reviews, cogently summarizing the state of the science… For those interested in a benchmark series of reviews on aging, this volume has much to offer. I recommend it highly. For geriatric neuropsychologists, sophistication about the biology of aging should be considered a required area of competence."--Archives of Clinical Neuropsychology


  • Part I: Basic Aging Processes

    1. The Genetic Network of Lifespan Extension by Dietary Restriction - Eric Greer and Anne Brunet

    2. Role of the Somatotropic Axis in Mammalian Aging - Holly M.Brown-Borg

    3. Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process - Casey L. Quinlan, Jason R. Treberg, and Martin D. Brand

    4. Aging and Apoptosis in Muscle - Stephen E. Alway, Michael R. Morissette, and Parco M. Siu

    5. Aging and Adipose Tissue - Roberta Florido, Tamara Tchkonia, and James L. Kirkland

    6. Aging of Stem Cells: Intrinsic Changes and Environmental Influences - Ling Liu and Thomas A. Rando

    7. Leukocyte Telomere Dynamics, Human Aging and Lifespan - Abraham Aviv

    8. An Unbiased Appraisal of the Free Radical Theory of Aging - Michael Lustgarten, Florian L. Muller, and Holly Van Remmen

    9. TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species - Pankaj Kapahi and Lutz Kockel

    10. Comparative Genetics of Aging - George L. Sutphin and Matt Kaeberlein

    11. Sirtuins in Aging and Age-Related Diseases - Marcia C. Haigis and David A. Sinclair

    12. Inflammation in Aging Processes: An Integrative and Ecological Perspective - Caleb E. Finch

    13. Protein Homeostasis and Aging - Susmita Kaushik and Ana Maria Cuervo

    Part II: Medical Physiology of Aging

    14. Terminal Weight Loss, Frailty, and Mortality - Edward J. Masoro

    15. Human Brain Myelination Trajectories Across the Lifespan: Implications for CNS Function and Dysfunction - Jonathan E. Sherin and George Bartzokis

    16. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions - Farzaneh A. Sorond and Lewis A. Lipsitz

    17. Aging and Insulin Secretion - Jeffrey B. Halter

    18. Cardiovascular Effects of Aging in Primates - Gender Differences - Hongyu Qiu, Christophe Depre, Dorothy E. Vatner, and Stephen F. Vatner

    19. Cerebral Vascular Dysfunction with Aging - Frank M. Faraci

    20. Pulmonary Function in Aging Humans - Nigel A.S. Taylor

    21. Calorie Restriction in Nonhuman and Human Primates - Luigi Fontana, Ricki J. Colman, John O. Holloszy, and Richard Weindruch

    22. Age-related Changes in Thermoreception and Thermoregulation - Eus J.W. Van Someren

    23. Sex Differences in Longevity and Aging - Steven N. Austad


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