Books in Toxicology

411-420 of 460 results in All results

Mechanisms of Drug Toxicity

1st Edition
January 1, 1968
H. Rašková
English
eBook
9 7 8 - 1 - 4 8 3 1 - 5 7 2 0 - 7

Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

Physico-Chemical Aspects of Drug Action

1st Edition
January 1, 1968
E. J. Ariëns
English
eBook
9 7 8 - 1 - 4 8 3 1 - 5 2 6 9 - 1

Physico-Chemical Aspects of Drug Action, Volume 7 covers topics on drug kinetics and the overall physicochemical properties of the drug in relation therewith, and the physicochemical aspects of the drug-receptor interaction, putting emphasis on receptor mechanisms and specific properties required for certain types of drugs in this respect. The book starts with some contributions dealing with various general aspects of drug kinetics followed by some contributions dealing with the relationship between certain physicochemical properties of drug molecules and their action. The text describes the pharmacokinetics and dose-concentration relationships; the time course of the biological response to drugs; and the empirical equations for correlating biological efficiency of organic compounds. The text also describes molecular basis for the action of chemotherapeutic drugs; the structure-activity studies on sulphonamides; and the water extrusion hypothesis. The mathematical treatment of two-point attachment between drug and receptor; the molecular properties and biological activity of catecholamines and certain related compounds; and the structure-activity relationships of diarylcarbinolethers are also considered. The book further tackles quantum mechanically-derived electronic distributions in the conformers of 2-pam; and the molecular basis for the action of certain drugs in the central nervous system. Pharmacologists and chemists will find the book invaluable.

Pharmacology of Pain

1st Edition
January 1, 1968
R. K. S. Lim + 2 more
English
eBook
9 7 8 - 1 - 4 8 3 1 - 5 5 2 8 - 9

Pharmacology of Pain, Volume 9 presents the proceedings of the 3rd International Pharmacological Meetings held in Sao Paulo in 1966. The book includes papers on the mediators of pain; proteolytic enzymes as mediators of pain; and desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors. The text also covers the sensitization of nociceptors by 5-hydroxytryptamine in man; the possible role of serotonin in affective component of pain behavioral reaction in the rat; and the use of pain induced functional impairment for assessing analgesic action. Papers on the clinical pharmacology of analgesics and analgesic antagonists; behavioral mechanisms of human pain; and central nervous mechanisms involved in pain and analgesia are also considered. The book further tackles the neuropharmacology of pain and analgesia; the interrelationship of cortical and subcortical pain systems; and the interaction of fast- and slow-conducting fiber systems involved in pain and analgesia.

Immunopharmacology

1st Edition
January 1, 1968
H. O. Schild + 1 more
English
eBook
9 7 8 - 1 - 4 8 3 1 - 5 0 4 2 - 0

Immunopharmacology is the 11th volume of the proceedings of the Third International Pharmacological Meeting held at Sao Paulo, Brazil on July 26, 1966. The volume covers papers that deal with immunoglobulins responsible for hypersensitivity reactions and with the mechanisms of these reactions; pharmacological mediators of immediate and delayed hypersensitivity; Arthus reactions; and soluble factors released by the action of antigen on sensitized lymphocytes. The book concludes with a single paper on the subject of penicillin allergy. Immunologists and pharmacologists will find the volume invaluable.

The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence

1st Edition
January 1, 1968
C. W. M. Wilson
English
eBook
9 7 8 - 1 - 4 8 3 1 - 8 6 1 6 - 0

The Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence is a collection of proceedings presented at the International Symposium on the Pharmacological and Epidemiological Aspects of Adolescent Drug Dependence, held in London on September 1-2, 1966 under the auspices of the Society for the Study of Addiction to Alcohol and Other Drugs. The symposium provided a forum for discussing the pharmacological and epidemiological aspects of drug dependence in adolescents. Comprised of 10 chapters, this volume begins with an overview of the chemistry and pharmacology of narcotic drugs in adolescence, as well as narcotic addiction in young people in the United States. The discussion then turns to pharmacology and clinical observations on stimulant drugs and hallucinogenic drugs; the epidemiology and social pharmacology of drugs of dependence; and features of adolescent drug dependence. Regulations aimed at controlling drugs of dependence are also analyzed in relation to the national incidence of adolescent dependence in certain countries such as Britain, Belgium, Israel, and the Netherlands. The remaining chapters focus on the language, evidence, and patterns of drug abuse, together with research in relation to drugs of dependence. This book will be of interest to pharmacologists, epidemiologists, and policymakers concerned with drug dependence.

Anabolic Steroids

1st Edition
January 1, 1968
H.-L. Krüskemper
English
eBook
9 7 8 - 1 - 4 8 3 2 - 6 5 0 4 - 9

Anabolic Steroids attempts to trace the development of anabolic steroids in the chemical, experimental biological, and clinical disciplines, and presents a precise outline of the current state of substantiated knowledge. This book deals with anabolic steroids derived from natural androgens and characterized by their stimulatory action on the biosynthesis of tissue protein and by their simultaneous low androgenicity. The biochemical part is a review of substantiated and current knowledge based largely on experimental results with animals, while the clinical part attempts to bring out the pathophysiological rationale of therapy with anabolic steroids, again based on experimental data. The book begins with a discussion of the nomenclature and chemistry of anabolic steroids. This is followed by separate chapters on the metabolism, activities, and mechanism of action of anabolic steroids; clinical application of anabolic steroids, side effects, and test procedures.

The Toxicology of Radioactive Substances

1st Edition
January 1, 1967
A. A. Letavet + 1 more
English
eBook
9 7 8 - 1 - 4 8 3 1 - 4 7 7 0 - 3

The Toxicology of Radioactive Substances, Volume 3: Iron-59 deals with the experimental results of tests conducted at the Radiotoxicology Laboratory of the Institute of Occupational Hygiene and Disease, Academy of Medical Sciences, U.S.S.R. The book focuses on studies made on iron-59, which is widely used in science and technology, such as in the metal industry and in the research of hemoglobin metabolism in the bone marrow and red cells. Other studies show, however, that there is a long-term detrimental effect of intake of iron-59. The text then gives a brief outline of the physical, chemical, and biological properties of iron. Research also shows that the body's reaction to radioactive substances depends on how these are transmitted to the body and on their physicochemical properties. The effect of prolonged administration of radioactive iron on the electrical activity of the cerebral cortex of animals is analyzed, of which, possibly, the nervous system is most affected. The book notes also the changes in the red blood cells during chronic administration of iron-59 in small doses, wherein the hemoglobin levels increased temporarily. Studies of prolonged exposure to radioactive isotopes during pregnancy of the test animals show that there are significant changes in erythropoiesis, associated with iron deficiency. In another study, the prolonged internal administration of radioactive substances showed phasic changes in the height of electrocardiographic waves of the test animals. The text is suitable for physicists, nuclear scientists, doctors of toxicology, and researchers in nuclear medicine.

Agricultural and Industrial Applications Environmental Interactions

1st Edition
January 1, 1967
Dewayne Torgeson
English
eBook
9 7 8 - 0 - 3 2 3 - 1 4 3 0 2 - 8

Fungicides, Volume I: Agricultural and Industrial Applications, Environmental Interactions discusses the application, use, and environmental interactions of fungicides. This book is organized into 15 chapters that cover the commercial development of fungicide and the organism's interaction with the environment. After discussing the history of fungicides, the book presents data on world fungicide usage and how this usage is influenced by epidemiology. It then describes procedures and approaches for commercial fungicide development; practical tests and laboratory techniques for agricultural fungicide toxicity; and significance of fungicide formulation that is determined by a variety of factors, including cost and biological efficiency. The following chapters discuss technological evolution, both in chemical fungicides and in the machinery for their application for soil and seed treatment. The application of foliar and postharvest fungicides and the use of other fungicides as industrial and wood preservatives is also tackled. The last four chapters are concerned with the various interactions between fungicides and the environment which may cause them to be more or less effective. The book will be useful to researchers, advanced students, and professional workers in the fungicide field of study who are concerned with the synthesis and development of better fungicides or their mode of action.

Titrations in Nonaqueous Solvents

1st Edition
January 1, 1967
Huber Walter
English
eBook
9 7 8 - 0 - 3 2 3 - 1 5 8 6 0 - 2

Titrations in Nonaqueous Solvents discuss the theory, practice, and data on acidic and basic strength of nonaqueous solvents. This book is organized into three parts encompassing six chapters. The first part considers the general principles of acids and bases and methods of end-point determination. This part also covers the fundamentals, advantages, and limitations of titration instruments, such as potentiometers, burets, titration vessels, and electrodes. The classification of titration solvents according to their functions as color indicators and titrant solutions is provided in this part. The remaining parts describe the analytical procedures for acidity and basicity of nonaqueous solvents. These parts also provide a tabulated data on the acidic and basic strengths, stability, and dissociation constants of various titration solvents. Analytical chemists, and analytical chemistry teachers and students will find this book invaluable.

Progress in Chemical Toxicology

1st Edition
January 1, 1967
Abraham Stolman
English
eBook
9 7 8 - 1 - 4 8 3 2 - 1 9 2 3 - 3

Progress in Chemical Toxicology, Volume 4 covers the capabilities of paper and thin-layer chromatography to separate closely resembling drugs and some of their metabolites. The book discusses the use of interfering compounds and artifacts in the identification of drugs in autopsy material; paper and thin layer chromatographic techniques for separation and identification of barbiturates and related hypnotics; and the forensic chemical detection of digitalis glycosides. The text also describes the applications of atomic absorption spectrometry to trace metal analyses of toxicological materials; and the toxicology of insecticides, rodenticides, herbicides, and phytopharmaceutical compounds. The combined action of drugs with toxicological implications is also considered. Chemists, toxicologists, biochemists, and forensics will find the book invaluable.