Toxicology Letters

Official Journal of EUROTOX

An international journal for the rapid publication of novel reports on a range of aspects of toxicology, especially mechanisms of toxicity.

Toxicology Letters serves as a multidisciplinary forum for research in toxicology. The prime aim is the rapid publication of research studies that are both novel and advance our understanding of a particular area. In addition to hypothesis-driven studies on mechanisms of mammalian toxicity, Toxicology Letters welcomes seminal work in the following areas:

In silico toxicology

Toxicokinetics

Physiologically-based pharmacokinetic (PBPK) modeling

Systems toxicology

Predictive toxicology

3R research in toxicology

New approach methodology (NAMs)

Adverse outcome pathways (AOPs)

Integrated testing strategies

Systematic and narrative reviews and mini-reviews in various areas of toxicology will be published. Clinical, occupational and safety evaluation, hazard and risk assessment, regulatory toxicology, impact on man, animal and environment studies of sufficient novelty to warrant rapid publication will be considered. Toxicology Letters also publishes editorials, commentaries and contemporary issues in toxicology.

The following types of work are not within the scopes of Toxicology Letters:

Ecotoxicology studies

Case studies

Chemoprevention studies

Pharmacological investigations

Authors are advised to follow the ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments; https://arriveguidelines.org/) and the OECD guidance document on Good In Vitro Method Practices (GIVIMP; https://www.oecd.org/env/guidance-document-on-good-in-vitro-method-practices-givimp-9789264304796-en.htm). In vitro or in vivo investigations conducted at concentrations or doses of no relevance to human or animal exposure will not be considered. Routes of exposure other than those relevant to human or animal exposure need to be justified. Assessment of dose-response should be an integral component of any toxicological research report. Unless adequately justified, studies conducted at a single dose level may not be considered. Test materials must be chemically defined and characterized. Investigations of chemically undefined plant extracts or uncharacterized nanoparticles will not be considered.