CHEST Journals

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Best of CHEST 2025

High impact articles

Asthma:

• Choosing the Right Biologic for the Right Patient With Severe Asthma

• The Role of Bronchial Biopsy in the Prediction of Response to Biologic Therapy in Severe Uncontrolled Asthma: A Prospective Study

Chest Infections:

• Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization: A Multicenter, Retrospective Study

• Diagnosis and Prevention of Invasive Fungal Infections in the Immunocompromised Host

• Effect of Metagenomic Next-Generation Sequencing on Clinical Outcomes of Patients With Severe Community-Acquired Pneumonia in the ICU: A Multicenter, Randomized Controlled Trial

• Impact of Cystic Fibrosis Transmembrane Conductance Regulator Modulators on Maternal Outcomes During and After Pregnancy

COPD:

• Effect of Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine on Exacerbation Rate and Risk in Patients With Moderate to Severe COPD

• Editing Approaches to Treat Alpha-1 Antitrypsin Deficiency

• The Emerging Role of Alarmin-Targeting Biologics in the Treatment of Patients With COPD

• Effect of Dupilumab on Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS

• Lessons Learned: Risk Factors and Clinical Impact of Severe Pneumothorax After Endoscopic Lung Volume Reduction With Endobronchial Valves

Critical Care:

• Demystifying Volume Status: An Ultrasound-Guided Physiologic Framework

• Treatment of Acute Circulatory Failure Based on Carbon Dioxide-Oxygen (CO₂-O₂) Derived Indices: The Lactel Randomized Multicenter Study

• Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial

• Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study

• High-Flow Nasal Cannula Liberation: Who, When, and How?

Diffuse Lung Disease:

• Diffuse Cystic Lung Disease: A Clinical Guide to Recognition and Management

• Airways Abnormalities in a Prospective Cohort of Patients With Rheumatoid Arthritis

• Single vs Double Lung Transplantation in Older Adults: A Propensity-Matched Analysis

• Effect of Admilparant, a Lysophosphatidic Acid Receptor 1 Antagonist, on Disease Progression in Pulmonary Fibrosis

• The Dawn of Precision Medicine in Fibrotic Interstitial Lung Disease

• Quantitative CT Scan Analysis in Rheumatoid Arthritis-Related Interstitial Lung Disease

Education and Clinical Practice:

• Risk Factors, Morbidity, and Mortality in Association With Preserved Ratio Impaired Spirometry and Restrictive Spirometric Pattern: Clinical Relevance of Preserved Ratio Impaired Spirometry and Restrictive Spirometric Pattern

• Nurse Practitioners and Physician Assistants: Building a Team and Optimizing Practice in the Medical ICU

Humanities:

• How Do Clinicians Use Quotations in Goals of Care Notes?

Pulmonary Vascular:

• Diagnosing Pulmonary Embolism During Pregnancy

• Treatment With Oral or Inhaled Treprostinil in Patients With Pulmonary Arterial Hypertension and Cardiovascular Comorbidities

Thoracic Oncology:

• A Prospective, Multicenter Evaluation of Safety and Diagnostic Outcomes With Robotic-Assisted Bronchoscopy: Results of the Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung (TARGET) Trial

• The Growth of Screening-Detected Pure Ground-Glass Nodules Following 10 Years of Stability

• Decídetexto: Mobile Cessation Support for Latino Adults Who Smoke: A Randomized Clinical Trial

• Interventions to Improve Adherence to Clinical Guidelines for the Management and Follow-Up of Pulmonary Nodules: A Systematic Review

• Lung Cancer Screening Adherence in Centralized vs Decentralized Screening Programs: A Meta-Analysis of US Cohort Studies Among Individuals With Negative Baseline Results

Sleep:

• Results of the Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-Controlled Study (SHARP): A Randomized Placebo-Controlled Double-Blind Repeated-Measures Crossover Phase IV Clinical Trial of the Effect of the Wake-Promoting Agent Solriamfetol on Cognitive Function in OSA With Excessive Daytime Sleepiness and Cognitive Impairment