Shaping Our Future

As Mayo Clinic Proceedings approaches its centennial celebration in April 2026, we reflect on a rich legacy of impactful research and groundbreaking advancements in medicine. This collection of articles showcases cutting-edge studies and innovative practices that tackle contemporary challenges in healthcare.

Join us as we continue to pave the way for the future of medicine, building on a foundation of excellence that has defined Mayo Clinic Proceedings for the past century.

Cardiology

• The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

• Safety of Triptans in Patients Who Have or Are at High Risk for Cardiovascular Disease: A Target Trial Emulation

• Impact of Cardiorespiratory Fitness on COVID-19eRelated Outcomes: The Exercise Testing and Health Outcomes Study (ETHOS)

• PostePulmonary Embolism Syndromed A Diagnostic Dilemma and Challenging Management

• Shock Severity Classification and Mortality in Adults With Cardiac, Medical, Surgical, and Neurological Critical Illness

• Calf rEF: Impact of Calf Muscle Pump Dysfunction With Reduced Ejection Fraction on All-Cause Mortality

• AI in Peer Review: Publishing’s Panacea or a Pandora’s Box of Problems?

• Life’s Essential 8 and Life’s Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project

• Temporal Association Between Vaping and Risk of Cardiac Events

Diabetes

• Management of Type 2 Diabetes Mellitus: Synopsis of the Department of Veterans Affairs and Department of Defense Clinical Practice Guideline

Ethics

• Pragmatic Clinical Trials: The Ethics of Conducting Research in the Real World

• Concepts and Approaches in the Management of Transgender and Gender-Diverse Patients

• Scholarly Debate About Drug Efficacy in Scientific Journals Is “Protected Speech,” Not Libel

Health Equity

• Measuring and Monitoring Health Equity in Health Care Organizations: Why It’s Important and How to Move Forward

• Management of the Vasomotor Symptoms of Menopause: Twofers in Your Clinical Toolbox

Lifestyle Medicine

• Older Tissue Age Derived From Abdominal Computed Tomography Biomarkers of Muscle, Fat, and Bone Is Associated With Chronic Conditions and Higher Mortality

• Association of a Mediterranean Lifestyle With All-Cause and Cause-Specific Mortality: A Prospective Study from the UK Biobank

• Physical Activity and Cause-Specific Cardiovascular Mortality Among People With and Without Cardiovascular Disease: A Cohort Study of 0.6 Million US Adults

Nephrology

• Management of Patients With Kidney Disease Undergoing Bariatric Surgery: A Multidisciplinary Approach

Obesity

• Bariatric and Metabolic Surgery in the Adult Population: What a Primary Care Provider Needs to Know

• Pharma-cise in the Glucagon-like Peptide-1 Receptor Agonists Era: A Concept Whose Time Has Come

Oncology

• Advances in Screening for Barrett Esophagus and Esophageal Adenocarcinoma

Patient Experience

• Never-Words: What Not to Say to Patients With Serious Illness

• Prescription Opioids and Brain Structure in Community-Dwelling Older Adults