World Cancer Day, 4 February 2025

Join us in commemorating World Cancer Day on 4th February by exploring our specially curated collection of articles that delve into the multi-faceted aspects of this pervasive disease. This collection will provide you with a comprehensive overview of the latest advancements in cancer research and treatment.

Annals of Oncology

• Acquired gene alterations in patients treated with ribociclib plus endocrine therapy or endocrine therapy alone using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2, -3, and -7 trials

• Tocilizumab provides dual benefits in treating immune checkpoint inhibitor-associated arthritis and preventing relapse during ICI rechallenge: the TAPIR study

Blood Neoplasia

• Real-world comparison of daratumumab-based regimens in relapsed/refractory multiple myeloma using health record data

• Venetoclax and hypomethylating agents in octogenarians and nonagenarians with acute myeloid leukemia

Cancer Epidemiology

• Ovarian cancer survival by stage, histotype, and pre-diagnostic lifestyle factors, in the prospective UK Million Women Study

• Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: A systematic review and meta-analysis

• ​Effect of post-diagnosis exercise on depression symptoms, physical functioning and mortality in breast cancer survivors: A systematic review and meta-analysis of randomized control trials

• Demographic and socioeconomic disparities in pediatric cancer in the United States: Current knowledge, deepening understanding, and expanding intervention

Clinical Breast Cancer

• Risk of Recurrence in Patients with HER2+ Early-Stage Breast Cancer: Literature Analysis of Patient and Disease Characteristics

• A phase II single-arm study of palbociclib in patients with HER2-positive breast cancer with brain metastases and analysis of ctDNA in patients with active brain metastases

• Robotics in Screening, Diagnosis and Treatment of Breast Cancer: A Perspective View

Clinical Colorectal Cancer

• ROCKET: Phase II Randomized, Active-controlled, Multicenter Trial to Assess the Safety and Efficacy of RRx-001 + Irinotecan vs. Single-agent Regorafenib in Third/Fourth Line Colorectal Cancer

• Colorectal Cancer Screening Disparities Among Race: A Zip Code Level Analysis

• Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study

Clinical Genitourinary Cancer

• Treatment Rechallenge With Immune Checkpoint Inhibitors in Advanced Urothelial Carcinoma

• Antibody-Drug Conjugates in Prostate Cancer: Where Are We?

Clinical Lung Cancer

• Liquid Biopsy Versus Tissue Biopsy to Determine Front Line Therapy in Metastatic Non-Small Cell Lung Cancer (NSCLC)

• 5-Year Real-World Outcomes With Frontline Pembrolizumab Monotherapy in PD-L1 Expression ≥ 50% Advanced NSCLC

• Trends in Stage I Lung Cancer

Clinical Lymphoma, Myeloma and Leukemia

• Real-World Use of Fedratinib for Myelofibrosis Following Prior Ruxolitinib Failure: Patient Characteristics, Treatment Patterns, and Clinical Outcomes

• The Dynamics of Financial Toxicity in Multiple Myeloma

Clinical Oncology

• DNA Repair Genetics and the Risk of Radiation Pneumonitis in Patients with Lung Cancer: A Systematic Review and Meta-analysis

• OSAIRIS: Lessons Learned From the Hospital-Based Implementation and Evaluation of an Open-Source Deep-Learning Model for Radiotherapy Image Segmentation

• Patient Experiences of Using Wearable Health Monitors During Cancer Treatment: A Qualitative Study

• Socioeconomic Deprivation Correlates With Incomplete Radiotherapy Treatment in Head and Neck Cancer

• Tumor Infiltrating Lymphocytes and Radiation Therapy in Rectal Cancer: Systematic Review and Meta-analysis

Critical Reviews in Oncology/Hematology

• Detecting BRAF mutations in colorectal cancer in clinical practice: An Italian experts' position paper

• Grading the evidence for physical activity and any outcome in cancer survivors: An Umbrella review of 740 meta-analytic associations

ESMO Gastrointestinal Oncology

• Concomitant proton pump inhibitors and capecitabine-based chemoradiotherapy in rectal cancer: an ancillary study from the PRODIGE 23 trial

• Managing zolbetuximab-induced nausea and vomiting: a proposal for a pragmatic approach in clinical practice

ESMO Open

• Progressive natural killer cell dysfunction in advanced-stage clear-cell renal cell carcinoma and association with clinical outcomes

• Results of a patient-level pooled analysis of three studies of trastuzumab deruxtecan in HER2-positive breast cancer with active brain metastasis

ESMO Real World Data and Digital Oncology

• Human epidermal growth factor receptor 2 (HER2) expression dynamics between diagnosis and recurrence in patients with breast cancer using artificial intelligence and electronic health records: the RosHER study

• Off-label drug use in oncology: integrating molecular and genetic analysis in an academic center’s real-world approach

European Journal of Surgical Oncology

• Lymph Node Metastasis Prediction Model for Each Lymph Node Station in Gastric Cancer Patients

• Multimodal prehabilitation in elective oncological colorectal surgery enhances postoperative functional recovery: a secondary analysis of the PREHAB randomized clinical trial

• Prediction and validation of pathologic complete response for locally advanced rectal cancer under neoadjuvant chemoradiotherapy based on a novel predictor using interpretable machine learning

• Robotic beyond total mesorectal excision for locally advanced rectal cancers: Perioperative and oncological outcomes from a multicentre case series

Gynecological Oncology Reports

• Cervical cancer management in a low resource setting: A 10-year review in a tertiary care hospital in Kenya

• Information needs during cancer care: Qualitative research with locally advanced cervical cancer patients in Brazil, China, Germany, & the US

• Public health concern-driven insights and response of low- and middle-income nations to the World Health Organization call for cervical cancer risk eradication

International Journal of Gynecological Cancer

• Minimally invasive compared to open surgery in patients with low-risk cervical cancer following simple hysterectomy: An exploratory analysis from the Gynecologic Cancer Intergroup/Canadian Cancer Trials Group CX.5/SHAPE trial

• The prognostic impact of molecular classification in endometrial cancer that undergoes fertility-sparing treatment

JACC: CardioOncology

• Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer: JACC: CardioOncology State-of-the-Art Review

• Cardiovascular Concerns, Cancer Treatment and Biological and Chronological Aging in Cancer: JACC Family Series

• Social Determinants of Health in Cardio-Oncology: Multi-level strategies to Overcome Disparities in Care: JACC: CardioOncology State-of-the-Art Review

• Air Pollution in Cardio-oncology and Unraveling the Environmental Nexus: JACC: CardioOncology State-of-the-Art Review

Journal of Bone Oncology

• Immune checkpoint inhibitors in bone metastasis: Clinical challenges, toxicities, and mechanisms

• Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma

• Targeting transforming growth factor beta signaling in metastatic osteosarcoma

Journal of Cancer Policy

• Cancer literacy – Informing patients and implementing shared decision making

• Current perspectives for external control arms in oncology clinical trials: Analysis of EMA approvals 2016–2021

• FDA validation of surrogate endpoints in oncology: 2005–2022

• Lost productivity due to head and neck cancer mortality in Hungary, Poland, and Romania

• Understanding the challenges of delivering radiotherapy in low- and middle-income countries in Africa

Journal of Liquid Biopsy

• Circulating tumor DNA kinetics: A future tool for radiation therapy personalization in lung cancer?

• Expanding the clinical utility of liquid biopsy by using liquid transcriptome and artificial intelligence

Journal of Thoracic Oncology

See the World Cancer Day 2025 Article Collection from Journal of Thoracic Oncology here.

Leukemia Research

• Real-world impact of luspatercept on red blood cell transfusions among patients with myelodysplastic syndromes: A United States healthcare claims database study

• Recent progress in pathological understanding of adult T-cell leukemia/lymphoma in the new classification era

• Treatment of Vietnamese patients diagnosed with myelodysplastic neoplasms: Practical experience in a developing country

• When the mask slips: A peripheral T-cell lymphoma disguised as lupus with myelofibrosis in a patient with May-Hegglin syndrome

Leukemia Research Reports

• Treatment of Vietnamese patients diagnosed with myelodysplastic neoplasms: Practical experience in a developing country

• When the mask slips: A peripheral T-cell lymphoma disguised as lupus with myelofibrosis in a patient with May-Hegglin syndrome

Oral Oncology

• HER2-targeted therapies for salivary gland cancers

• PRT543, a protein arginine methyltransferase 5 inhibitor, in patients with advanced adenoid cystic carcinoma: An open-label, phase I dose-expansion study

Oral Oncology Reports

• Epidemiology and survival analysis of head and neck cancer: Results from comprehensive care center in North India

• Trends in the applications of terahertz radiation in oral oncology treatments

International Journal of Radiation Oncology, Biology, Physics

• The Lancet Oncology Commission: Radiotherapy & Theranostic Services in LMICs: Minding & Mending the Gaps

Seminars in Oncology

• Outcomes with panobinostat in heavily pretreated multiple myeloma patients

• PARP inhibitors: A review of the pharmacology, pharmacokinetics, and pharmacogenetics

Seminars in Ultrasound, CT and MRI

• Imaging Prognostic Biomarkers in Hepatocellular Carcinoma: A Comprehensive Review

• The Ninth Edition TNM Staging Classification for Thymic Epithelial Tumors

• Ultrasound of Skin Cancer: What We Need to Know

Surgical Oncology

• Machine learning for predicting colon cancer recurrence

• Melanoma sentinel lymph node biopsy in the modern era

• Robotic distal pancreatectomy using a docking-free system (the hinotori™ Surgical Robot System)

Surgical Oncology Insight

• Assessing the OPRA trial for surgical oncologists: Safety and feasibility of a total neoadjuvant therapy approach in patients with rectal cancer

• Multidisciplinary management of pleomorphic dermal sarcoma of the scalp: A single institution study

• A practical approach for drain fluid analysis following genitourinary surgery

• Evolving patterns of metastatic spread, treatment, and outcome for patients with oligometastatic colorectal cancer

• Intra-pleural and intra-peritoneal tocilizumab therapy for managing malignant pleural effusions and ascites: The Regional Immuno-Oncology Trial (RIOT)-2 study protocol

• Miscategorized lymph nodes in colorectal cancer: a potential pitfall of pre-surgical imaging