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Zebrafish at the Interface of Development and Disease Research - 1st Edition - ISBN: 9780128033081, 9780128033432

Zebrafish at the Interface of Development and Disease Research, Volume 124

1st Edition

Serial Volume Editor: Kirsten Sadler Edepli
Hardcover ISBN: 9780128033081
eBook ISBN: 9780128033432
Imprint: Academic Press
Published Date: 23rd March 2017
Page Count: 384
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Table of Contents

Chapter One: Modeling Syndromic Congenital Heart Defects in Zebrafish

  • Abstract
  • 1 Introduction
  • 2 Zebrafish Heart Development
  • 3 Zebrafish Models of Syndromic CHD
  • 4 Conclusion
  • Acknowledgments

Chapter Two: Using Zebrafish to Study Kidney Development and Disease

  • Abstract
  • 1 Introduction
  • 2 Conserved Features of Vertebrate Kidney Development: Zebrafish as a Model System
  • 3 Disease and Development: CAKUT in Zebrafish
  • 4 Renal Ciliopathy Models in Zebrafish
  • 5 Kidney Injury and Regeneration
  • 6 Stem/Progenitor Cells in Kidney Repair and Regeneration
  • 7 Using Zebrafish to Uncover Potential Treatments for AKI
  • 8 Future Directions
  • Acknowledgments

Chapter Three: Zebrafish Developmental Models of Skeletal Diseases

  • Abstract
  • 1 Introduction
  • 2 Bone and Cartilage: Overview of Zebrafish Skeletal Development
  • 3 Synthesis of the Cartilage Matrix Components
  • 4 Processing of ECM Macromolecules
  • 5 Zebrafish Models of Axial Skeleton Defects
  • 6 Concluding Remarks
  • Funding and Acknowledgments

Chapter Four: Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish

  • Abstract
  • 1 Introduction
  • 2 Development of the Hematopoietic System in Zebrafish
  • 3 Interrogating Hematopoiesis in the Zebrafish Model
  • 4 Investigating Adult HSC Maintenance and Function
  • 5 Modeling Hematological Diseases in Zebrafish
  • 6 Concluding Remarks
  • Acknowledgments

Chapter Five: Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research

  • Abstract
  • 1 Introduction
  • 2 Liver Development: Zebrafish as a Paradigm
  • 3 Liver Regeneration
  • 4 Strengths and Challenges of Using Zebrafish to Study Liver Regeneration
  • 5 Concluding Remarks: How Studying Liver Development and Regeneration Provides an Understanding of Liver Disease
  • Acknowledgments

Chapter Six: “Muscling” Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish

  • Abstract
  • 1 Introduction
  • 2 From Mesoderm to Musculature: Overview of Skeletal Muscle Development
  • 3 Trademark Traits of Skeletal Muscle: Muscle Cell Fusion and Sarcomeres
  • 4 MTJ Development
  • 5 From Development to Homeostasis
  • 6 New Insights Into Muscle Disease From Zebrafish
  • 7 Conclusions and Future Prospects
  • Acknowledgments

Chapter Seven: Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies

  • Abstract
  • 1 Introduction to the Pancreas
  • 2 Gene-Function Analysis Streamlined in Zebrafish
  • 3 Developing Renewable Sources of Beta Cells for Cell-Based Diabetes Therapies
  • 4 Pancreas Regeneration as a Therapeutic Tool
  • 5 Pancreas as a Metabolic Regulator: Studying Metabolic Disease in Zebrafish
  • 6 Future Directions
  • Acknowledgments

Chapter Eight: Modeling Infectious Diseases in the Context of a Developing Immune System

  • Abstract
  • 1 Introduction
  • 2 Development of the Cell Types of the Innate Immune System
  • 3 Genetic Control and Experimental Manipulation of the Zebrafish Innate Immune System
  • 4 Pathways Required for Pathogen Recognition and Activation of the Innate Immune Response
  • 5 Effects of Commensal Microbes on Development of the Immune System
  • 6 Adaptation to Infection and Inflammation
  • 7 The Interface of Immunity and Metabolism
  • 8 Recent Insights From Modeling Infectious Diseases in Developing Embryos and Larvae
  • 9 Concluding Remarks
  • Acknowledgments

Chapter Nine: Zebrafish in Toxicology and Environmental Health

  • Abstract
  • 1 Introduction
  • 2 Historical Perspective: Toxicology and Government Efforts for Environmental Regulation
  • 3 Environmental and Developmental Toxicology
  • 4 Zebrafish: Testing the Waters for Toxicants
  • 5 Transcriptional Profiling to Identify Contaminants
  • 6 High-Throughput Screening for Toxicity Studies
  • 7 Assessing Health Impacts of Environmental Exposures Using Zebrafish
  • 8 Long-Term and Transgenerational Effects of Toxin Exposures
  • 9 Pathways and Mechanisms of Toxicant-Induced Disease
  • 10 Limitations to the Zebrafish Model System
  • 11 Conclusions
  • Acknowledgments


Zebrafish at the Interface of Development and Disease Research presents the latest on the shared pathways that govern development and contribute to disease. Zebrafish have traditionally been used to study vertebrate development, providing interesting data on the developmental processes and genes that are implicated in disease. This new release in the series contains informative discussions on congenital heart defects in zebrafish, the use of zebrafish in studying kidney development and disease, and muscle development, homeostasis and disease in zebrafish. Each chapter  interweaves the study of zebrafish development and its application to the immune system, the kidney, liver, heart and others.

Key Features

  • The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece
  • Leading experts in the field - all of them running zebrafish focused labs for each chapter


Zebrafish researchers, members of the Zebrafish Disease Models Society and basic researchers in pathology


No. of pages:
© Academic Press 2017
23rd March 2017
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editor

Kirsten Sadler Edepli

Dr. Kirsten Sadler Edepli is a cell biologist and geneticist whose research focuses on the molecular basis of liver development and two important liver diseases, liver cancer and fatty liver disease. After studying biology and Anthropology at Mount Holyoke College in MA, she obtained a Masters in Medical Sciences at Harvard Medical School (1994) and a Ph.D. in Cell and Developmental Biology at Harvard University (1998). She joined the faculty at Bosphorus University in Istanbul/Turkey and then moved to work with Nancy Hopkins at MIT where she screened for zebrafish mutants with liver disease and growth defects. She started her lab as assistant professor in Departments of Medicine and of Developmental and Regenerative Biology at The Icahn School of Medicine at Mount Sinai in New York in 2006, where she was promoted to associate professor in 2013. In 2015, she joined the faculty of New York University in Abu Dhabi as a tenured associate professor in the Biology Program. She runs an active research group focused on epigenetic control of liver development, regeneration and cancer and on the fatty liver disease. She teaches, is an active member of the NYU academic community, and serves her passion of promoting gender equity in science, technology, engineering and math (STEM) through a range of activities, including serving as the faculty advisor for Women Empowered in STEM at NYUAD.

Affiliations and Expertise

New York University Abu Dhabi, UAE