What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology

1st Edition, Volume 158 - March 28, 2021
Editors: Adam Thomas Brockett, Linda M. Amarante, Mark Laubach, Matthew R. Roesch
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 3 6 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 3 7 - 8

What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognit… Read more

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What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more.

Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal’s decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.

1. From affective to cognitive processing: Functional organization of the medial frontal cortex

Joseph Simon IV, Peter H. Rudebeck and Erin L. Rich

2. Medial prefrontal cortex encoding of stress and anxiety

David S. Jacobs and Bita Moghaddam

3. Integration of value and action in medial prefrontal neural systems

Beata Kaminska, Jessica P. Caballero and David E. Moorman

4. Dynamic decision making and value computations in medial frontal cortex

Bilal A. Bari and Jeremiah Y. Cohen

5. Reward signaling by the rodent medial frontal cortex

Mark Laubach, Linda M. Amarante, Marcelo S. Caetano and Nicole K. Horst

6. The anterior cingulate cortex and event-based modulation of autonomic states

Jeremy K. Seamans

7. Valence processing in the PFC: Reconciling circuit-level and systems-level views

Austin A. Coley, Nancy Padilla-Coreano, Reesha Patel and Kay M. Tye

8. Social processing by the primate medial frontal cortex

Philip T. Putnam and Steve W. C. Chang

9. Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision making systems

Amber E. McLaughlin, Geoffrey W. Diehl and A. David Redish

10. Anterior cingulate cortex and adaptive control of brain and behavior

Adam T. Brockett and Matthew R. Roesch

11. Oscillations as a window into neuronal mechanisms underlying dorsal anterior cingulate cortex function

Benjamin Voloh, Rachel Knoebl, Jan Zimmermann and Benjamin Y. Hayden

12. Neuronal oscillations and the mouse prefrontal cortex

Felix Jung and Marie Carlén

13. Prefrontal contributions to action control in rodents

Stefanie Hardung, Zoe Jäckel and Ilka Diester

14. The midcingulate cortex and temporal integration

Emmanuel Procyk, Vincent Fontanier, Matthieu Sarazin, Bruno Delord, Clément Goussi and Charlie R. E. Wilson

15. Medial prefrontal cortex and the temporal control of action

Qiang Zhang, Matthew A. Weber and Nandakumar S. Narayanan

16. Secondary motor cortex: Broadcasting and biasing animal’s decisions through long-range circuits

Jen-Hau Yang and Alex C. Kwan

Adam Thomas Brockett

Adam Thomas Brockett – Dr. Adam Brockett is a post-doctoral fellow at the University of Maryland, College Park working in the laboratory of Professor Matthew Roesch, exploring the neural correlates of cognitive control across the lifespan. Adam attended the University of Maryland, College Park earning a Bachelor of Science degree in Psychology, and a minor in Neuroscience in 2011. Throughout his undergraduate career, Adam worked as a Student Intramural Research Training Awardee (IRTA) at the NIH in the laboratory of Dr. James Winslow investigating the effects of fluoxetine and differential rearing on social behaviors in rhesus macaques. Following graduation, Adam was a post-baccalaureate fellow (IRTA) at the NIH and worked to develop molecular techniques for the generation of transgenic marmosets under the guidance of Dr. James Pickel. Adam received his PhD from Princeton University working with Professor Elizabeth Gould in 2017. His work with Professor Gould characterized the role of astrocytes in medial prefrontal cortex function and their contributions to cognitive control. Adam received a F32 Ruth L. Kirschstein National Research Service Award (NRSA) in the spring of 2019.

Affiliations and expertise

Department of Psychology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park, USA

Linda M. Amarante

Linda M. Amarante – Dr. Linda M. Amarante recently received her PhD in neuroscience from American University in Spring 2020. At American University, she performed research in Dr. Mark Laubach’s laboratory studying the medial frontal cortex and its role in reward-based behaviors and value-based decision making in rats. Her dissertation work investigated the role of the medial and orbital frontal cortices in signaling reward information, which was supported by a Graduate Research Fellowship (GRFP) from the National Science Foundation in 2016. Linda received undergraduate degrees in Psychology and English from Long Island University in 2013, where she performed research on opioids and prenatal mouse development under the guidance of Dr. Grace Rossi. Linda also currently curates projects and runs social media for the Open Behavior project, which is a repository of open-source tools for behavioral neuroscience. She will begin a post-doctoral fellowship with Dr. Jeremiah Cohen at the Johns Hopkins University School of Medicine.

Affiliations and expertise

Department of Neuroscience, American University, Washington, USA

Mark Laubach

Mark Laubach – Dr. Laubach is a professor of neuroscience at American University. His lab studies the role of the medial frontal cortex in goal-directed behavior. Core methods include multi-electrode recordings, optogenetics, multivariate statistics, and computational models of neural circuits. The lab is currently supported by the NIH to study the role of opioid receptors in the prefrontal cortex in reward-guided decisions. In addition, Dr. Laubach and his lab collaborate with Dr. Alexxai Kravitz from Washington University to run the OpenBehavior project, which promotes open-source tools used in behavioral neuroscience research. Dr. Laubach is Director of American University’s PhD program in neuroscience and serves on the editorial boards of eNeuro, The Journal of Neuroscience, and Behavioral Neuroscience.

Affiliations and expertise

Professor of Neuroscience, Department of Neuroscience, American University, Washington, USA

Matthew R. Roesch

Matthew R. Roesch – Dr. Roesch’s research investigates the neural mechanisms underlying executive control, and their disturbance in drug abuse. Specifically, Dr. Roesch’s lab records single unit activity from multiple brain regions as rats perform a variety of behavioral tasks (e.g. reversal, delay discounting, stop-signal, set-shifting, conflict, social distress, etc) and evaluate loss of function after pharmacological and optogenetic manipulation. Dr. Roesch has over 20 years of experience performing, analyzing, and publishing on this type of research. He completed his dissertation work in the lab of Dr. Carl Olson in the Department of Neuroscience (CNUP) and the Center for the Neural Basis of Cognition (CNBC) at the University of Pittsburgh. There, he recorded from single neurons in several areas in primate frontal and medial cortex during performance of reward and conflict based saccade tasks. After graduating, he accepted a position as post-doctoral fellow on the Cellular and Integrative Neuroscience Post-Doctoral Training Grant at the University of Maryland Medical School under the advisement of Dr. Geoff Schoenbaum. There he continued his work on issues pertaining to value-guided decision-making and reversal learning. Dr. Roesch is currently full professor at the University of Maryland College Park as part of the Department of Psychology and the Program in Neuroscience and Cognitive Science. He is Cognitive and Neural Systems Area Head for Psychology, and Associate Director and Admissions Director for the Neuroscience and Cognitive Science Program.

Affiliations and expertise

Department of Psychology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park, USA