Wall & Melzack's Textbook of Pain

6th Edition

Expert Consult - Online and Print


  • Stephen McMahon
  • Martin Koltzenburg
  • Irene Tracey
  • Dennis Turk
  • Key Features

    • Benefit from the international, multidisciplinary knowledge and experience of a "who's who" of international authorities in pain medicine, neurology, neurosurgery, neuroscience, psychiatry, psychology, physical medicine and rehabilitation, palliative medicine, and other relevant fields.
    • Access the complete contents online anytime, anywhere at www.expertconsult.com.

    Table of Contents

    Section I: Neurobiology of Pain

    1 Peripheral Mechanisms of Cutaneous Nociception

    2 Molecular Biology of Sensory Transduction

    3 Inflammatory Mediators and Modulators of Pain

    4 Microglia: Critical Mediators of Pain Hypersensitivity after Peripheral Nerve Injury

    5 Neuroanatomical Substrates of Spinal Nociception

    6 Spinal Cord Plasticity and Pain

    7 Representation of Pain in the Brain

    8 Central Nervous System Mechanisms of Pain Modulation

    9 Development of Pain Pathways and Mechanisms

    10 Genetics of Pain

    11 Animal Models of Pain

    12 Ascending Projection Systems

    13 Autonomic, Endocrine, and Immune Interactions in Acute and Chronic Pain

    14 Itch

    Section II: Assessment and Psychology of Pain

    15 Gender Differences in Pain and Its Relief

    16 Epidemiology of Pain

    17 Emotion, Motivation, and Pain

    18 Cognitive and Learning Aspects

    19 Psychiatric Pain-Associated Co-morbidities

    20 Studies of Pain in Human Subjects

    21 Pain Measurement in Adult Patients

    22 Pain in Older Persons

    23 Measurement and Assessment in Pediatric Pain

    24 Assessment of Pain Beliefs, Coping and Function

    25 Hypnotic Analgesia

    26 Pain, Opiates, and Addiction

    27 Placebo Analgesia

    Section III: Pharmacology and Treatment of Pain

    28 Spinal Pharmacology of Nociceptive Transmission

    29 Methods of Therapeutic Trials

    30 Opioids: Basic Mechanisms

    31 Opioids: Clinical Use

    32 Cyclooxygenase Inhibitors: Basic Aspects

    33 Cyclooxygenase Inhibitors: Clinical Use

    34 Antidepressants Analgesics

    35 Mechanism of Action of Anticonvulsants as Analgesic Drugs

    36 Anticonvulsants: Clinical

    37 Local Anaesthetic Blocks and Epidurals

    38 Cannabinoids

    39 Analgesic Drugs i


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    © 2013
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    About the authors

    Stephen McMahon

    Affiliations and Expertise

    Sherrington Professor of Physiology, Director, London Pain Consortium, Academic Lead, Europain, Wolfson Centre for Age-Related Diseases, King's College London, UK

    Martin Koltzenburg

    Affiliations and Expertise

    Professor of Clinical Neurophysiology, UCL Institute of Neurology; Co-Director, MRC Centre for Neuromuscular Diseases, University College London; Head of Department, Department of Clinical Neurophysiology, The National Hospital for Neurology and Neurosuryger, UCLH NHS Foundation Trust, Queen Square, London, UK

    Irene Tracey

    Affiliations and Expertise

    Nuffield Professor of Anaesthetic Science; Director, Oxford Centre for FMRI of Brain; Head, Nuffield Division Anaesthetics, Nuttfield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

    Dennis Turk

    Affiliations and Expertise

    John and Emma Bonica Professor of Anesthesiology and Pain Research, University of Washington School of Medicine; Director, Center for Pain Research on Impact, Measurement, And Effectiveness (C-PRIME), Seattle, Washington