Vitamin D

Vitamin D

Volume 1: Biochemistry, Physiology and Diagnostics

4th Edition - December 14, 2017

Write a review

  • Editors: Martin Hewison, Roger Bouillon, Edward Giovannucci, David Goltzman
  • Hardcover ISBN: 9780128099650
  • eBook ISBN: 9780128099667

Purchase options

Purchase options
DRM-free (PDF, EPub, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.

Key Features

  • Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D
  • Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles
  • Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency
  • Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications


Academic, medical, and pharmaceutical researchers in bone biology, physiology, biochemistry; clinician researchers in endocrinology, nephrology, oncology, immunology, orthopedic surgery, and radiology

Table of Contents

  • Volume 1: Biochemistry, Physiology and Diagnostics 

    David Feldman, J. Wesley Pike, Roger Bouillon, Edward Giovannucci, David Goltzman and Martin Hewison

    In Memoriam: Robert P. Heaney, MD (1928-2016)
    Robert R. Recker and Joan M. Lappe
    In Memoriam: Milan Uskokovic, PhD (1924-2015)
    Sylvia Christakos, Hubert Maehr, and Nanjoo Suh

    Section I. History, Chemistry Metabolism, Circulation & Regulation
    1. Historical Overview of Vitamin D
    Hector F. DeLuca
    2. Evolutionary Biology: Mysteries of Vitamin D in Fish
    David R. Fraser
    3. Evolution of Human Skin Color and Vitamin D
    Nina G. Jablonski
    4. Photobiology of Vitamin D
    Michael F. Holick
    5. The Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases)
    Glenville Jones, David E. Prosser, and Martin Kaufmann
    6. CYP24A1: Structure, Function, and Physiological Role
    René St-Arnaud and Glenville Jones
    7. The Vitamin D Binding Protein DBP
    Roger Bouillon and Steven Pauwels
    8. Regulation of renal and extra-renal 1α-hydroxylase
    Dean P. Larner, John S. Adams, and Martin Hewison

    Section II. Mechanism of Action
    9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells 
    J. Wesley Pike, Mark B. Meyer, Seong Min Lee, Melda Onal, and Nancy Benkusky
    10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor
    John H. White, Reyhaneh Salehi-Tabar, Vassil Dimitrov, and Manuella Bouttier
    11. Structural basis for ligand activity in VDR
    Anna Y. Belorusova and Natacha Rochel
    12. Ligand Independent Actions of Vitamin D Receptor
    Gilles Laverny and Daniel Metzger
    13. Vitamin D and Chromatin
    Carsten Carlberg
    14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR
    Mark B. Meyer, Nancy A. Benkusky, J. Wesley Pike
    15. Vitamin D and microRNAs
    Hengguang Zhao, Sri Ramulu N. Pullagura, Sandra Rieger and Thomas S. Lisse
    16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions
    Mathew T. Mizwicki, Anthony W. Norman

    Section III. Mineral and Bone Homeostasis
    17. Vitamin D Regulation of Osteoblast Function
    Jeroen van de Peppel, Renny T. Franceschi, Yan Li, and Bram C.J. van der Eerden
    18. Osteoclastogenesis and Vitamin D
    Yuko Nakamichi, Naoyuki Takahashi, Nobuyuki Udagawa, and Tatsuo Suda
    19. Vitamin D Activities in Osteocytes
    Paul H. Anderson, Gerald J. Atkins, Howard A. Morris, and David M. Findlay
    20. Regulation of Intestinal Calcium and Phosphate Absorption
    James C. Fleet
    21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6
    Sylvia Christakos, Leila J. Mady, and Puneet Dhawan
    22. Calcium homeostasis and eggshell biomineralization in female chicken
    Yves Nys and Nathalie Le Roy
    23. Mineralization in Mammals
    Adele L. Boskey
    24. Cartilage
    Barbara D. Boyan, Maryam Doroudi, Kayla Scott, and Zvi Schwartz
    25. Vitamin D and Bone: An Integrated Approach
    Geert Carmeliet

    Section IV. Extra-Skeletal Targets
    26. Vitamin D and the Kidney
    Peter J. Tebben and Rajiv Kumar
    27. Vitamin D and the Parathyroids
    Justin Silver and Tally Naveh-Many
    28. The Calcium-sensing Receptor and Vitamin D
    Geoffrey N. Hendy
    29. Vitamin D in Dentoalveolar and Oral Health
    Brian L. Foster and Philippe P. Hujoel
    30. The Role of Vitamin D and its Receptor in Hair Follicle Biology
    Marie B. Demay
    31. Vitamin D, Calcium and the Epidermis
    Daniel D Bikle
    32. Vitamin D and the Cardiovascular System
    Amy E. Riek, Rithwick Rajagopal, and Carlos Bernal-Mizrachi
    33. Vitamin D Brain Development and Function
    Darryl Eyles and John McGrath
    34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms
    Carmen J. Narvaez, Donald G. Matthews, and JoEllen Welsh
    35. Vitamin D and Skeletal Muscle
    Christian M. Girgis
    36. Understanding Vitamin D from mouse knockout models
    David Goltzman, Geoffrey N. Hendy, Andrew C. Karaplis, Richard Kremer, Denshun Miao

    Section V. Human Physiology
    37. Pharmacology and pharmacokinetics
    Inez Schoenmakers and Kerry S. Jones
    38. Vitamin D Role in the Calcium and Phosphorus Economies
    Robert P. Heaney and Laura A.G. Armas
    39. Fetus, Neonate and Infant
    Christopher S. Kovacs
    40. Consequences of perinatal vitamin D deficiency on later bone health
    Cyrus Cooper, Elizabeth M. Curtis, Rebecca J. Moon, Elaine M. Dennison, and Nicholas C. Harvey
    41. Adolescence and Acquisition of Peak Bone Mass
    Richard Lewis, Emma Laing, and Connie Weaver
    42. Pregnancy, Lactation, and Post-Weaning Recovery
    Christopher S. Kovacs
    43. Role in Reproductive Biology and Reproductive Dysfunction in Women
    Lubna Pal and Hugh S. Taylor
    44. Vitamin D, reproductive biology, and dysfunction in men
    Ida Marie Boisen, Lasse Bøllehuus Hansen, Li Juel Mortensen, and Martin Blomberg Jensen
    45. Vitamin D and the Renin-Angiotensin System
    Yan Chun Li
    46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin
    John J. Wysolmerski
    47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity
    L. Darryl Quarles

    Section VI. Diagnosis and Management
    48. Approach to the Patient with Metabolic Bone Disease
    Michael P. Whyte
    49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology
    Fabrizio Bonelli, and Bruce W. Hollis
    50. Mass Spectrometry Assays of Vitamin D Metabolites
    Martin Kaufmann, Lusia Sepiashvili, and Ravinder J. Singh
    51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects
    Rene F. Chun and Carrie M. Nielson
    52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation
    Christopher T. Sempos, Graham D. Carter, and Neil C. Binkley
    53. Bone Histomorphometry
    Juliet Compston, Linda Skingle, and David W. Dempster
    54. Radiology of Rickets and Osteomalcia
    Judith E. Adams
    55. High-resolution Imaging Techniques for Bone Quality Assessment
    Andrew J. Burghardt, Roland Krug, Sharmila Majumdar
    56. The Role of Vitamin D in Orthopedic Surgery
    Aasis Unnanuntana, Aleksey Dvorzhinskiy, Brian J. Rebolledo, Shevaun M. Doyle, Panagiota Andreopoulou, and Joseph M. Lane
    Introduction to chapters 57 a and b
    57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position
    Roger Bouillon and Cliff Rosen
    57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position
    Reinhold Vieth and Michael F. Holick

Product details

  • No. of pages: 1180
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: December 14, 2017
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128099650
  • eBook ISBN: 9780128099667

About the Editors

Martin Hewison

Prof. Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Prof. Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.

Affiliations and Expertise

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

Roger Bouillon

Roger Bouillon, MD, PhD, FRCP, biography Roger Bouillon is professor (emeritus since 2010) in endocrinology (internal medicine) at the University and University Hospital of the Catholic University of Leuven (K.U.Leuven) in Belgium. He is a member of the Royal Academy of Medicine (Belgium) and a Fellow of the Royal College of Physicians (London). He was a founding member and later President of the European Board of Endocrinology (UEMS 1988-2002). He was a member of several European Science Foundation Committees (Board member of the European Medical Research Council) and of the European Space Agency Life Science working group till 2012. He is past-president of the International Bone and Mineral Society (2011-13 ) and is co-organizer of the vitamin D workshop. He was vice president for research of the University of Leuven from 1995-2005. He is coauthor of more than 500 peer reviewed articles that generated about 26,000 ISI citations and a H index of 82. The topics of his research deal with (1) several aspects of diabetes an endocrinology in general but his main research focus deals with (2) hormonal aspects of bone and calcium homeostasis and this spans the spectrum of basic, translational and clinical research. (3) Vitamin D is a major research focus throughout his scientific career. Papers:

Affiliations and Expertise

Professor in Endocrinology, University and University Hospital, Catholic University of Leuven (K.U.Leuven), Belgium

Edward Giovannucci

Edward Giovannucci's research focuses on how nutritional, genetic, environmental and lifestyle factors relate to various malignancies, especially those of the prostate and large bowel. Much of his work is centered on large ongoing cohort studies, including the Nurses Health Study, the Health Professionals Follow-Up Study and the Physicians Health Study. A specific area of interest is the etiologic mechanisms underlying the relation between modifiable factors and cancer risk. His work has included the study of how nutrition and other lifestyle factors impact on cancer risk and progression by influencing levels of insulin, insulin-like growth factors, vitamin D metabolites, and steroid hormones. Another area of interest is how nutrients may interact with genetic susceptibilities in determining an individual's risk.

Affiliations and Expertise

Harvard TH Chan School of Public Health, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

David Goltzman

David Goltzman is Professor in the Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician in the Endocrine Division of the Department of Medicine of the McGill University Health Centre. His research has focused on the hormonal regulation of mineral and skeletal homeostasis, and he has made many important contributions to our knowledge of parathyroid hormone (PTH), PTH related peptide and vitamin D, which have had major impact on our understanding of a variety of metabolic bone diseases. He is also principal investigator of the Canadian Multicentre Osteoporosis Study (CaMos) which examines the demographics, development, risk factors and outcomes of osteoporosis. Dr. Goltzman has received various honours and awards, including the Aurbach Award of the US Endocrine Society, the Raisz Award of the American Society for Bone and Mineral Research (ASBMR), fellowship in the Royal Society of Canada and in the Canadian Academy of Health Sciences, the Order of Canada, an honorary professorship from Nanjing University and the degree of Doctor Honoris Causa from the University of Athens. He is a past President of the ASBMR, the Canadian Society of Clinical Investigation and the Canadian Society of Endocrinology and Metabolism.

Affiliations and Expertise

Professor, Departments of Medicine and Physiology of McGill University, Director of the McGill Centre for Bone and Periodontal Research, and Senior Physician, Endocrine Division, Department of Medicine of the McGill University Health Centre, Canada

Ratings and Reviews

Write a review

Latest reviews

(Total rating for all reviews)

  • BarbaraCohen B. Tue Jul 03 2018

    Vitamin D, Ed Feldman et al, 2017

    Most chapters are very helpful, being both comprehensive, clearly written and well referenced. However a few sections seemed not to cover the whole of their heading topic, especially noted in the chapter on diabetes, which was mainly on type 1 diabetes, and did not cover the associations of type 2 diabetes as well as I would have hoped.