Vitamin D - 2nd Edition - ISBN: 9780122526879, 9780080543642

Vitamin D

2nd Edition

Editors: David Feldman J. Wesley Pike Francis Glorieux
eBook ISBN: 9780080543642
Imprint: Academic Press
Published Date: 23rd December 2004
Page Count: 1952
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Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

Key Features

Most comprehensive, up-to-date two-volume set on Vitamin D New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more Further sections on emerging uses for treatments of auto-immune diseases and diabetes Over 600 illustrations and figures available on CD


Bone specialists, endocrinologists, basic scientists and researchers interested in vitamin D and osteoporosis prevention.

Table of Contents

INTRODUCTION CH 1: Historical Perspective

SECTION I: CHEMISTRY, METABOLISM, AND CIRCULATION CH 2: Vitamin D Metabolism CH 3: Photobiology of Vitamin D CH 4: The Vitamin D-25 Hydroxylase CH 5: The 25-Hydroxyvitamin D 1-alpha-Hydroxylase CH 6: The 25-Hydroxyvitamin D 24-Hydroxylase CH 7: Mutant Mouse Models of Vitamin D Metabolic Enzymes CH 8: Vitamin D Binding Protein CH 9: New Aspects of DBP CH 10: Endocytic Pathways for 25-(OH) Vitamin D3

SECTION II: MECHANISM OF ACTION CH 11: The Vitamin D Receptor CH 12: Vitamin D Receptor Promoter and Regulation of Receptor Expression CH 13: Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions CH 14: Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity CH 15: VDR LBD Crystal Structures CH 16: Comodulators of VDR-Mediated: Gene Expression CH 17: Promoter Targeting of VDR Through A Chromatin Remodeling Complex CH 18: Molecular Basis of the Diversity of Vitamin D Target Genes CH 19: Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene CH 20: Mouse Models of Vitamin D Receptor Ablation CH 21: Intranuclear Vitamin D Response Element Binding CH 22: VDR and RXR Subcellular Trafficking CH 23: 1a,25(OH)2¡Vvitamin D3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s)

SECTION III: MINERAL HOMEOSTASIS CH 24: Vitamin D and the Intestinal Absorption of Calcium: A View and Overview CH 25: Intestinal Calcium Absorption: Lessons from Knock Out Mice and Men CH 26: Phosphate Homeostasis CH 27: Mineralization CH 28: Modeling and Remodeling: How Bone Cells Work Together CH 29: Vitamin D and the Kidney CH 30: Vitamin D and the Parathyroids CH 31: Calcium-Sensing Receptor

SECTION IV: TARGET ORGANS AND ACTIONS: A. Organs/Tissues CH 32: Bone CH 33: Cartilage and Vitamin D: Genomic and Nongenomic Regulation CH 34: Dento-Alveolar Bone Complex and Vitamin D CH 35: Role in Skin and Hair CH 36: Regulation of Immune Responses by Vitamin D Receptor Ligands CH 37: Osteoblasts CH 38: Vitamin D and Osteoclastogenesis CH 39: Vitamin D Control of the Calcitonin Gene in Thyroid C Cells CH 40: Vitamin D Regulation of Type I Collagen Expression in Bone CH 41: Target Genes: Bone Proteins CH 42: The Calbindins: Calbindin-D9k and Calbindin-D28k CH 43: Target Genes CH 44: Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin D Endocrine System CH 45: Vitamin D and the Cellular Response to Oxidative Stress

SECTION V: HUMAN PHYSIOLOGY CH 46: Vitamin D: Role in the Calcium Economy CH 47: Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism CH 48: Perinatal Vitamin D Actions CH 49: Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood CH 50: Vitamin D Metabolism and Aging CH 51: Vitamin D Metabolism in Pregnancy and Lactation CH 52: Vitamin D and Reproductive Organs CH 53: Vitamin D Receptor as a Sensor for Toxic Bile Acids CH 54: The Renin-Angiotensin System CH 55: Vitamin D and Muscle CH 56: Vitamin D and Cardiovascular Medicine

SECTION VI: DIAGNOSIS AND MANAGEMENT CH 57: Approach to the Patient with Metabolic Bone Disease CH 58: Detection of Vitamin D and Its Major Metabolites CH 59: Bone Histomorphometry CH 60: Radiology of Rickets and Osteomalacia CH 61: The Pharmacology of Vitamin D, Including Fortification Strategies

SECTION VII: DISORDERS OF THE VITAMIN D: ENDOCRINE SYSTEM CH 62: How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview CH 63: Vitamin D and the Pathogenesis of Rickets and Osteomalacia CH 64: The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D CH 65: Vitamin D Deficiency and Nutritional Rickets in Children CH 66: Vitamin D Insufficiency in Adults and the Elderly CH 67: Vitamin D and Osteoporosis CH 68: Genetic Vitamin D Receptor Polymorphisms and Risk of CH 69: Clinical Disorders of Phosphate Homeostasis CH 70: Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor Induced Osteomalacia, Fibrous Dysplasia, and the Pathophysiological Relevance of FGF23 TIO, ADDR FGF-23 CH 71: Vitamin D Pseudodeficiency CH 72: Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets CH 73: Glucocorticoids and Vitamin D CH 74: Drug and Hormone Effects on Vitamin D Metabolism CH 75: Bone Disorders Associated with Gastrointestinal & Hepatobiliary Disease CH 76: Vitamin D and Renal Failure CH 77: Idiopathic Hypercalciuria and Nephrolithiasis CH 78: Hypercalcemia Due to Vitamin D Toxicity CH 79: Extra-renal 1„´-hydroxylase Activity and Human Disease

SECTION VIII: NEW VITAMIN D ANALOGS CH 80: Overview: Rational Design of 1a,25-Dihydroxyvitamin D3 Analogs (Deltanoids) CH 81: Analog Metabolism CH 82: Mechanisms for the Selective Actions of Vitamin D Analogs CH 83: Molecular Basis for Differential Action of Vitamin D Analogs CH 84: Development of New Vitamin D Analogs CH 85: Geminis: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains CH 86: Development of OCT and ED-71 CH 87: 2-Carbon-Modified Analogs of 19-Nor- 1a,25-Dihydroxyvitamin D3 CH 88: Non-steroidal Analogs

SECTION IX: VITAMIN D AND CANCER CH 89: Vitamin D: Cancer and Differentiation CH 90: Vitamin D, Sunlight, and the Natural History of Prostate Cancer CH 91: Epidemiology of Cancer Risk: Vitamin D and Calcium CH 92: Differentiation and the Cell Cycle CH 93: Vitamin D and Breast Cancer CH 94: Vitamin D and Prostate Cancer CH 95: Vitamin D and Colon Cancer CH 96: Vitamin D and Hematological: Malignancy CH 97: Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Considerations for Future Development

SECTION X: EMERGING USES: Overview: Vitamin D Vs. Calcium Effects CH 98: Vitamin D3: Autoimmunity and Immunosuppression CH 99: Vitamin D and Diabetes CH 100: Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders CH 101: Psoriasis and Other Skin Diseases CH 102: Muscles and Falls CH 103: Renal Failure and Secondary Hyperparathyroidism CH 104: Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands


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© Academic Press 2005
Academic Press
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About the Editor

David Feldman

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

Affiliations and Expertise

Emeritus Professor of Medicine, Stanford University School of Medicine, Stanford, California, USA

J. Wesley Pike

Dr. Pike’s laboratory is focused on the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. A long-term area of interest has been in the actions of vitamin D. His laboratory has shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. This research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action.

Affiliations and Expertise

Professor, Department of Biochemistry, University of Wisconsin, Madison, USA

Francis Glorieux

Affiliations and Expertise

Professor of Surgery, Pediatrics and Human Genetics, McGill University; Adjunct Professor of Pediatrics, University of Montreal; Director of Research, Shriners Hospital for Children, Montreal, QC Canada


"...half an hour's study of its pages will bring the reader closer to the facts than will hours of Web surfing." - Martijn B. Katan, Ph.D, Wageningen University, The Netherlands for THE NEW ENGLAND JOURNAL OF MEDICINE (2(2005) "This is a valuable and comprehensive resource on vitamin D that could be of use to a variety of researchers from different disciplines. ...This book is invaluable to anyone who has an interst in vitamin D and should be on their bookshelf as a first-line reference." - Wiener Medizinische Wochenschrisft (2006) "Doody's 4-star review: An encyclopedia and thorough work -- a virtual must for most medical libraries. The index is excellent and the bibliogpraphic citations of high value." --Eugene A. Davison, PhD (Georgetown University School of Medicine)

Ratings and Reviews