Vitamin D

Vitamin D

2nd Edition - December 23, 2004

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  • Editors: David Feldman, J. Wesley Pike, Francis Glorieux
  • eBook ISBN: 9780080543642

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Description

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

Key Features

*Most comprehensive, up-to-date two-volume set on Vitamin D
*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
*Further sections on emerging uses for treatments of auto-immune diseases and diabetes
*Over 600 illustrations and figures available on CD

Readership

Bone specialists, endocrinologists, basic scientists and researchers interested in vitamin D and osteoporosis prevention.

Table of Contents

  • INTRODUCTION
    CH 1: Historical Perspective

    SECTION I: CHEMISTRY, METABOLISM, AND CIRCULATION
    CH 2: Vitamin D Metabolism
    CH 3: Photobiology of Vitamin D
    CH 4: The Vitamin D-25 Hydroxylase
    CH 5: The 25-Hydroxyvitamin D 1-alpha-Hydroxylase
    CH 6: The 25-Hydroxyvitamin D 24-Hydroxylase
    CH 7: Mutant Mouse Models of Vitamin D Metabolic Enzymes
    CH 8: Vitamin D Binding Protein
    CH 9: New Aspects of DBP
    CH 10: Endocytic Pathways for 25-(OH) Vitamin D3

    SECTION II: MECHANISM OF ACTION
    CH 11: The Vitamin D Receptor
    CH 12: Vitamin D Receptor Promoter and Regulation of Receptor Expression
    CH 13: Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions
    CH 14: Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity
    CH 15: VDR LBD Crystal Structures
    CH 16: Comodulators of VDR-Mediated: Gene Expression
    CH 17: Promoter Targeting of VDR Through A Chromatin Remodeling Complex
    CH 18: Molecular Basis of the Diversity of Vitamin D Target Genes
    CH 19: Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene
    CH 20: Mouse Models of Vitamin D Receptor Ablation
    CH 21: Intranuclear Vitamin D Response Element Binding
    CH 22: VDR and RXR Subcellular Trafficking
    CH 23: 1a,25(OH)2¡Vvitamin D3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s)

    SECTION III: MINERAL HOMEOSTASIS
    CH 24: Vitamin D and the Intestinal Absorption of Calcium: A View and Overview
    CH 25: Intestinal Calcium Absorption: Lessons from Knock Out Mice and Men
    CH 26: Phosphate Homeostasis
    CH 27: Mineralization
    CH 28: Modeling and Remodeling: How Bone Cells Work Together
    CH 29: Vitamin D and the Kidney
    CH 30: Vitamin D and the Parathyroids
    CH 31: Calcium-Sensing Receptor

    SECTION IV: TARGET ORGANS AND ACTIONS:
    A. Organs/Tissues
    CH 32: Bone
    CH 33: Cartilage and Vitamin D: Genomic and Nongenomic Regulation
    CH 34: Dento-Alveolar Bone Complex and Vitamin D
    CH 35: Role in Skin and Hair
    CH 36: Regulation of Immune Responses by Vitamin D Receptor Ligands
    CH 37: Osteoblasts
    CH 38: Vitamin D and Osteoclastogenesis
    CH 39: Vitamin D Control of the Calcitonin Gene in Thyroid C Cells
    CH 40: Vitamin D Regulation of Type I Collagen Expression in Bone
    CH 41: Target Genes: Bone Proteins
    CH 42: The Calbindins: Calbindin-D9k and Calbindin-D28k
    CH 43: Target Genes
    CH 44: Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin D Endocrine System
    CH 45: Vitamin D and the Cellular Response to Oxidative Stress

    SECTION V: HUMAN PHYSIOLOGY
    CH 46: Vitamin D: Role in the Calcium Economy
    CH 47: Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism
    CH 48: Perinatal Vitamin D Actions
    CH 49: Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood
    CH 50: Vitamin D Metabolism and Aging
    CH 51: Vitamin D Metabolism in Pregnancy and Lactation
    CH 52: Vitamin D and Reproductive Organs
    CH 53: Vitamin D Receptor as a Sensor for Toxic Bile Acids
    CH 54: The Renin-Angiotensin System
    CH 55: Vitamin D and Muscle
    CH 56: Vitamin D and Cardiovascular Medicine

    SECTION VI: DIAGNOSIS AND MANAGEMENT
    CH 57: Approach to the Patient with Metabolic Bone Disease
    CH 58: Detection of Vitamin D and Its Major Metabolites
    CH 59: Bone Histomorphometry
    CH 60: Radiology of Rickets and Osteomalacia
    CH 61: The Pharmacology of Vitamin D, Including Fortification Strategies

    SECTION VII: DISORDERS OF THE VITAMIN D: ENDOCRINE SYSTEM
    CH 62: How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview
    CH 63: Vitamin D and the Pathogenesis of Rickets and Osteomalacia
    CH 64: The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D
    CH 65: Vitamin D Deficiency and Nutritional Rickets in Children
    CH 66: Vitamin D Insufficiency in Adults and the Elderly
    CH 67: Vitamin D and Osteoporosis
    CH 68: Genetic Vitamin D Receptor Polymorphisms and Risk of
    CH 69: Clinical Disorders of Phosphate Homeostasis
    CH 70: Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor Induced Osteomalacia, Fibrous Dysplasia, and the Pathophysiological Relevance of FGF23 TIO, ADDR FGF-23
    CH 71: Vitamin D Pseudodeficiency
    CH 72: Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets
    CH 73: Glucocorticoids and Vitamin D
    CH 74: Drug and Hormone Effects on Vitamin D Metabolism
    CH 75: Bone Disorders Associated with Gastrointestinal & Hepatobiliary Disease
    CH 76: Vitamin D and Renal Failure
    CH 77: Idiopathic Hypercalciuria and Nephrolithiasis
    CH 78: Hypercalcemia Due to Vitamin D Toxicity
    CH 79: Extra-renal 1„´-hydroxylase Activity and Human Disease

    SECTION VIII: NEW VITAMIN D ANALOGS
    CH 80: Overview: Rational Design of 1a,25-Dihydroxyvitamin D3 Analogs (Deltanoids)
    CH 81: Analog Metabolism
    CH 82: Mechanisms for the Selective Actions of Vitamin D Analogs
    CH 83: Molecular Basis for Differential Action of Vitamin D Analogs
    CH 84: Development of New Vitamin D Analogs
    CH 85: Geminis: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains
    CH 86: Development of OCT and ED-71
    CH 87: 2-Carbon-Modified Analogs of 19-Nor- 1a,25-Dihydroxyvitamin D3
    CH 88: Non-steroidal Analogs

    SECTION IX: VITAMIN D AND CANCER
    CH 89: Vitamin D: Cancer and Differentiation
    CH 90: Vitamin D, Sunlight, and the Natural History of Prostate Cancer
    CH 91: Epidemiology of Cancer Risk: Vitamin D and Calcium
    CH 92: Differentiation and the Cell Cycle
    CH 93: Vitamin D and Breast Cancer
    CH 94: Vitamin D and Prostate Cancer
    CH 95: Vitamin D and Colon Cancer
    CH 96: Vitamin D and Hematological: Malignancy
    CH 97: Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Considerations for Future Development

    SECTION X: EMERGING USES:
    Overview: Vitamin D Vs. Calcium Effects
    CH 98: Vitamin D3: Autoimmunity and Immunosuppression
    CH 99: Vitamin D and Diabetes
    CH 100: Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders
    CH 101: Psoriasis and Other Skin Diseases
    CH 102: Muscles and Falls
    CH 103: Renal Failure and Secondary Hyperparathyroidism
    CH 104: Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands

Product details

  • No. of pages: 1960
  • Language: English
  • Copyright: © Academic Press 2004
  • Published: December 23, 2004
  • Imprint: Academic Press
  • eBook ISBN: 9780080543642

About the Editors

David Feldman

David Feldman, MD, is Emeritus Professor of Medicine (Active) at Stanford University School of Medicine where he has been on the faculty since 1974. He has been a full professor since 1984 and was chief of the Endocrinology Division for 10 years. His laboratory studies the role of steroid hormone receptors, particularly the vitamin D receptor, and its mechanism of action. His current major research focus is hormone-dependent cancer including breast cancer and prostate cancer and the pathways by which vitamin D inhibits cancer growth. Professor Feldman is actively involved in both basic science approaches to the anti-cancer actions of vitamin D as well as to clinical trials studying the use of vitamin D in breast and prostate cancer. Professor Feldman was recently honored with an award for a Career of Outstanding Contributions to Vitamin D Research. He has authored over 290 medical research articles, reviews, editorials, and book chapters. In addition to being a co-editor of all four editions of OSTEOPOROSIS, he is the editor-in-chief of Vitamin D, just published in its third edition.

Affiliations and Expertise

Emeritus Professor of Medicine, Stanford University School of Medicine, Stanford, California, USA

J. Wesley Pike

Dr. Pike’s laboratory is focused on the molecular mechanisms whereby vitamin D, the sex steroids, and other systemic hormones regulate the production as well as cellular activity of bone-forming osteoblasts and bone-resorbing osteoclasts. A long-term area of interest has been in the actions of vitamin D. His laboratory has shown that these actions are mediated by a specific receptor that is localized to the nucleus of target cells and which functions as a transcription factor following activation by its hormonal vitamin D ligand. This research led to the molecular cloning of this factor and elucidation of its regulation and mechanism of action.

Affiliations and Expertise

Professor, Department of Biochemistry, University of Wisconsin, Madison, USA

Francis Glorieux

Affiliations and Expertise

Professor of Surgery, Pediatrics and Human Genetics, McGill University; Adjunct Professor of Pediatrics, University of Montreal; Director of Research, Shriners Hospital for Children, Montreal, QC Canada

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